A5079943099- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- interferon and immune responses
- Aquaculture disease management and microbiota
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Advanced Biosensing Techniques and Applications
University of Córdoba
2022-2025
Instituto Maimónides de Investigación Biomédica de Córdoba
2022-2025
Biomedical Research Institute
2022-2025
SARS-CoV-2, the causative agent of present COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome, and some have been implicated facilitating infection pathogenesis through their interaction with cellular components. Among these proteins, protein ORF7a ORF7b functions are poorly understood. In this study, A549 cells were transduced to express ORF7b, respectively, explore more depth role each pathological manifestation leading COVID-19. Bioinformatic analysis integration...
The host response to S. Typhimurium infection can be post-transcriptionally regulated by miRNAs. In this study, we investigated the role of miR-215 using both in vivo porcine models and vitro intestinal epithelial cell lines. Several miRNAs were found dysregulated ileum during with wild-type SPI2-defective mutant strains Typhimurium, some changes being SPI2-dependent. Notably, was significantly downregulated infection. To explore its functional role, gain-of-function experiments performed...
Antiviral signaling, immune response and cell metabolism are dysregulated by SARS-CoV-2, the causative agent of COVID-19. Here, we show that SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c ORF10 induce a significant mitochondrial metabolic reprogramming in A549 lung epithelial cells. While induced largely overlapping transcriptomes, ORF3a distinct transcriptome, including downregulation numerous genes with critical roles function morphology. On other hand, all four ORFs altered dynamics...
SARS-CoV-2, the cause of COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. In this study, transcriptomics analysis revealed that both WNT5A and IL11 were significantly up-regulated A549 cells expressing individual ORF6, ORF8, ORF9b or ORF9c from SARS-CoV-2 (Wuhan-Hu-1 isolate). is a member IL6 family cytokines. signaling-related genes also differentially expressed. Bioinformatics disclosed involved...
From the early days of COVID-19 pandemic, an excessive release proinflammatory cytokines, such as IL6, was detected in serum from patients. As a consequence, several anti-inflammatory drugs, Dexamethasone (a strong corticoid), were used to counteract cytokine storm occurring during severe disease. By contrast, pro-inflammatory interleukin 11 (IL11), member IL6 family, respiratory tissues infected patients and experimental epithelial cellular models. In this work, human A549 lung cells...
ABSTRACT Antiviral signaling, immune response and cell metabolism in human body are dysregulated by SARS-CoV-2, the causative agent of COVID-19. Here, we show that SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c ORF10 induce a significant mitochondrial metabolic reprogramming A549 lung epithelial cells. While all four ORFs caused fragmentation altered function, only ORF3a induced marked structural alteration cristae. largely overlapping transcriptomes. In contrast, distinct transcriptome,...
Abstract SARS-CoV-2, the causative agent of present COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome, and some have been implicated facilitating infection pathogenesis through their interaction with cellular components. Among these proteins, protein ORF7a ORF7b functions are poorly understood. In this study, A549 cells were transduced to express ORF7b, respectively, explore more depth role each pathological manifestation leading COVID-19. Bioinformatic analysis...
Summary SARS-CoV-2, the cause of COVID19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. Transcriptomic analysis revealed that both WNT5A and IL11 were significantly up-regulated A549 cells expressing individual ORF6, ORF8, ORF9b or ORF9c from SARS-CoV-2 (Wuhan-Hu-1 isolate). signaling-related genes also differentially expressed. Bioinformatics disclosed involved pulmonary fibrosis idiopathic disease....