A5055640237- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Mesenchymal stem cell research
- Hip disorders and treatments
- Muscle activation and electromyography studies
- Nerve Injury and Rehabilitation
- Musculoskeletal pain and rehabilitation
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Silk-based biomaterials and applications
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Inflammatory mediators and NSAID effects
- Pluripotent Stem Cells Research
- Total Knee Arthroplasty Outcomes
- Extracellular vesicles in disease
- Periodontal Regeneration and Treatments
- Circular RNAs in diseases
- Shoulder and Clavicle Injuries
Shanghai Changzheng Hospital
2014-2024
Second Military Medical University
2015-2022
Objective. To evaluate the effect of Kartogenin-pretreated exosomes derived from infrapatellar fat pad mesenchymal stem cells on chondrocyte in vitro and articular cartilage regeneration vivo. Methods. Infrapatellar (IPFP-MSCs) were isolated rabbits to harvest exosomes. After identification exosomes, rabbit chondrocytes divided into three groups for further treatment: EXO group (chondrocytes treated with cells), KGN-EXO pretreated KGN), control group. processing proliferation, phenotypic...
Rotator cuff injury healing is problematic because the tendon-bone junction often forms cicatricial tissues, rather than fibrocartilage, which leads to mechanical impairment and prone redamage. Kartogenin (KGN) a newly discovered small molecule compound can induce cartilage formation through chondrogenesis of endogenous mesenchymal stem cells. In this study, we used KGN with fibrin glue (FG) repair rotator by promoting fibrocartilage at tendon bone interface. Firstly, assessed release rate...
Abstract Objective The choice of osteotomy in joint replacement surgery for Crowe type IV developmental dysplasia the hip (DDH) is a challenging and controversial procedure. In this study, we compared clinical efficacy combination greater trochanter tension wire fixation with that subtrochanteric osteotomy. Methods We performed 15 primary total arthroplasty (THA) procedures between January 2016 July 2020 on 13 patients (the GTT group) 12 THA 11 using STO group). mean follow-up was 2.8 years...
We aimed to assess the efficacy of applying a two-stage primary total knee arthroplasty (TKA) with an antibiotic-laden cement spacer block treat infected osteoarthritic knees.This retrospective study included 17 cases severely knees treated TKA. Open debridement and irrigation insertion well-designed antibiotic was performed as first stage. Systemic antibiotics were used in interval period. Two-stage TKAs after elimination infection. The pre- post-operative Hospital for Special Surgery Knee...
Purpose . The purpose of this study was to cross-culturally adapt and validate the Simplified Chinese version Lower Extremity Functional Scale (SC-LEFS). Methods original English translated adapted into according international guidelines. SC-LEFS 36-Item Short-Form Health Survey were administered 213 patients with lower extremity musculoskeletal disorders. Psychometric properties including internal consistency, test-retest reliability, content validity, construct validity tested. Results...