A5051936100- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Peripheral Artery Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Diagnosis and Treatment of Venous Diseases
- Adipose Tissue and Metabolism
- Infective Endocarditis Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Workplace Health and Well-being
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Hemodynamic Monitoring and Therapy
- Systemic Sclerosis and Related Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Lymphatic System and Diseases
- Long-Term Effects of COVID-19
- Atrial Fibrillation Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Frailty in Older Adults
- Inflammasome and immune disorders
- Vascular Procedures and Complications
- Diet and metabolism studies
- COVID-19 and healthcare impacts
- Adolescent and Pediatric Healthcare
University of Freiburg
2021-2025
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2022-2025
University Medical Center Freiburg
2021-2024
University of Würzburg
2012-2018
Universitätsklinikum Würzburg
2015-2018
Summary: Background: Older patients with peripheral artery disease (PAD) encounter an increased risk of in-hospital mortality. Accurate scoring methods are crucial for assessing the likelihood cardiovascular events in these patients. However, a comprehensive comparison predicting mortality PAD has not yet been conducted. Patients and methods: This study analyzed 173,075 hospitalized year 2020 from German nationwide registry. We assessed five scores: Elixhauser Comorbidity Index, Charlson CHA...
Depression is common in heart failure and associated with adverse clinical outcomes. We investigated the potential of 2-item patient health questionnaire (PHQ-2) versus that 9-item version (PHQ-9) to predict death or rehospitalization.Participants Interdisciplinary Network for Heart Failure program were eligible, if they completed PHQ-9 during baseline assessment. All participants hospitalized cardiac decompensation had a left ventricular ejection fraction ≤40% before discharge. PHQ-2 scores...
Abstract Aims The distinct functions of immune cells in atherosclerosis have been mostly defined by pre-clinical mouse studies. Contrastingly, the cell composition human atherosclerotic plaques and their contribution to disease progression are only poorly understood. It remains uncertain whether genetic animal models allow for valuable translational approaches. Methods results Single-cell RNA-sequencing (scRNA-seq) was performed define landscape carotid plaques. repertoire demonstrated an...
Background The COVID-19 pandemic developed its full destructive capacity in 2020. This retrospective study aimed to examine the effects of on mortality and clinical characteristics PAD patients with compared without COVID-19. Methods results Data derived from a German nationwide register year 2020 which encompassed all hospitalized ( n = 173.075); N 2553 also suffered infection had significantly higher rates 11.2%. + presented more complications like major amputations (11.59%), myocardial...
Objective: The accumulation of inflammatory leukocytes is a prerequisite adipose tissue inflammation during cardiometabolic disease. We previously reported that genetic deficiency the intracellular signaling adaptor TRAF5 (TNF [tumor necrosis factor] receptor–associated factor 5) accelerates atherosclerosis in mice by increasing cell recruitment. Here, we tested hypothesis an impairment modulates and its metabolic complications model diet-induced obesity mice. Approach Results: To induce...
Depression ist bei Herzinsuffizienz eine häufige Komorbidität, die Lebensqualität und Prognose verschlechtert. Beides sind Volkskrankheiten mit steigender Prävalenz, verursachen hohe Behandlungskosten, deshalb auch sozioökonomisch relevant. Komplexe sich wechselseitig ungünstig beeinflussende biologische verhaltensbezogene Faktoren (z. B. geringere Therapieadhärenz depressiven Herzinsuffizienten), aber partiell gemeinsame genetische Disposition scheinen pathophysiologisch relevant zu sein....
Rationale Atherosclerosis is a chronic inflammatory disease of large arteries that involves an autoimmune response with autoreactive T cells and auto-antibodies recognizing Apolipoprotein B (ApoB), the core protein low-density lipoprotein (LDL). Here, we aimed to establish clinical association between circulating human ApoB atherosclerosis its risk factors using novel assay detect against pool highly immunogenic ApoB-peptides. Methods Results To polyclonal IgM- IgG-antibodies ApoB, developed...
Abstract Background The Covid-19 pandemic developed its full destructive capacity and caused over 6.6 million confirmed deaths worldwide in the year 2020. This retrospective study aimed to examine effects of on mortality clinical characteristics peripheral artery disease (PAD) patients because these chronically ill are at risk for arterial embolic vascular complications a fatal outcome. Methods results From German nationwide registry 2020 all hospitalized with PAD (n=173.075) were compared...
Abstract Background and objectives Limb ischemia or compartment syndrome, requiring surgery, are some of the frequent cannula-related complications in patients supported with veno-arterial extracorporeal membrane oxygenation (VA-ECMO). The purpose this exploratory study is to depict evaluate dynamic changes lower limb muscles ultrasound shear wave elastography as marker for early ischemia. Methods Eleven VA-ECMO after cardiac arrest were included study. Seven received distal perfusion...
Background: Symptomatic peripheral arterial disease (PAD) is difficult to non-invasively diagnose in the presence of calcified, media sclerotic arteries that are incompressible by blood pressure cuffs. Standard ankle-brachial index (ABI) measurements these PAD patients very often not helpful. Shear wave elastography (SWE) a modern ultrasound technique detect muscle stiffness changes i.e. weakness during exercise. In pilot study, we examined whether SWE could be reproducible tool for...
Introduction: Chronic systolic heart failure (CHF) is a major cause of death and hospitalization. There growing interest in psychosomatic factors impacting on outcome CHF. Both obesity cachexia were shown to influence the CHF patients. We investigated prevalence prognostic impact eating disorders (reduced appetite or overeating) mortality risk Hypothesis: Reduced overeating predict reduced survival Methods: 864 patients hospitalized for cardiac decompensation with left ventricular ejection...
Abstract Introduction and aim Current emergency treatment options for severe aortic valve stenosis include surgical replacement (SAVR), transcatheter (TAVR) balloon valvuloplasty (BV). So far no larger patient population has been evaluated regarding clinical characteristics outcomes. Therefore we aimed to describe the use outcome of three therapy in a broad registry study. Method results Using German nationwide electronic health records, admissions symptomatic patients with between 2014...
In der vorliegenden Dissertation wurde anhand von post- hoc Analysen aus dem Datensatz des Interdisziplinaren Netzwerkes Herzinsuffizienz (INH, Unique identifier: ISRCTN 23325295) die prognostische Bedeutung depressiver Symptome bei Patienten mit systolischer bestimmt. Dazu wurden n=852 untersucht, zur Baseline alle einen PHQ-9 Fragebogen Erhebung ihrer depressiven ausgefullt hatten. Es konnte gezeigt werden, dass sich kurzere Version PHQ-9, PHQ-2, ebenso gut zum Screening fur Depression...
Abstract Background Symptomatic peripheral artery disease (PAD) is challenging to diagnose in the presence of media sclerosis with incompressible arteries since standard ankle-brachial index (ABI) cannot be applied. Shear wave elastography (SWE) provides a novel ultrasound technique measure muscle stiffness and visualize deficits at rest during contraction. Furthermore, reduced correlates possible hypoperfusion affected area. It fast, non-invasive associated weakness chronic heart failure...
This study aimed to evaluate the acute treatment of patients with severe aortic valve stenosis in Germany.Three strategies 11,027 acutely admitted due were compared from 2014 until 2018 using German nationwide records: The annual number transcatheter replacement (TAVR) procedures (1,294 1,827) and balloon valvuloplasty (BV only) (170 233) increased, but surgical (SAVR) decreased (426 316). In comparison BV only (mean age 81.3; EuroSCORE 23.2) SAVR younger at lower logistic 66.9; 9.4)....