- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Cervical and Thoracic Myelopathy
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Musculoskeletal pain and rehabilitation
- Virus-based gene therapy research
- Spinal Dysraphism and Malformations
- Orthopedic Surgery and Rehabilitation
- Bone Tumor Diagnosis and Treatments
- Head and Neck Cancer Studies
- Liver physiology and pathology
- Vascular Malformations Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- RNA Interference and Gene Delivery
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Brain Metastases and Treatment
- Elbow and Forearm Trauma Treatment
- Cell death mechanisms and regulation
- Airway Management and Intubation Techniques
- Curcumin's Biomedical Applications
- Infectious Diseases and Tuberculosis
East Suffolk and North Essex NHS Foundation Trust
2023-2024
Institut Català d'Oncologia
2020
University of Cambridge
2016-2018
Addenbrooke's Hospital
2016-2018
Center for Research and Advanced Studies of the National Polytechnic Institute
2007-2015
Instituto Politécnico Nacional
2007-2015
National Hospital for Neurology and Neurosurgery
2011-2014
University College London
2011-2014
Hospital del Trabajador
2014
Federico II University Hospital
2008-2012
Here we evaluated the ability of l-theanine in preventing experimental hepatic cirrhosis and investigated roles nuclear factor-κB (NF-κB) activation as well transforming growth factor β (TGF-β) connective tissue (CTGF) regulation. Experimental was established by administration carbon tetrachloride (CCl 4 ) to rats (0.4 g/kg, intraperitoneally, three times per week, for 8 weeks), at same time, adding (8.0 mg/kg) drinking water. Rats had ad libitum access water food throughout treatment...
Several types of C1-C2 fixation techniques have been described over the years in order to treat atlantoaxial instability.To compare pros and cons most popular posterior used today: C1 lateral mass-C2 pedicle screw rods (Harms) transarticular (Magerl) fixations.Retrospective review 122 patients who underwent Harms or Magerl for instability. Surgical, clinical, radiological outcomes were compared 2 groups.123 operations performed, which 47 by technique (group H) 76 M). No significant...
A retrospective, comparative cohort study was performed of metacarpophalangeal or proximal interphalangeal joint arthrodesis with either tension band ( n = 28) compression (Acutrak Mini) screw 29) methods. We compared rate union, healing time, complications, and re-operation rate. Union achieved in 26/28 (92.8%) the group (9.4 weeks) 24/28 (85.7%) (9.8 weeks). Only 28 patients were assessed for union as one patient sustained a fracture at time insertion converted to fixation. The...
Meningiomas with exclusive or prevalent dural attachment over the transverse-sigmoid sinus junction area represent a well-defined subgroup of posterior fossa meningiomas. This study reports 13 cases this localisation (10.8% all infratentorial meningiomas). In series, six patients (46%) were discovered as an incidental MR finding. One patient small (1.5 cm) meningioma presented intracranial hypertension syndrome due to severe obstruction unique junction. A angiography was performed in 11...
Objectives To report an exceptional case of dural arteriovenous fistula the tentorial incisura presenting as transient and recurrent isolated paresis fourth cranial nerve, treated by endovascular embolization. Case A 63-year-old man presented several episodes intermittent diplopia which appeared during sudden head movements in left lower gaze. Magnetic resonance cerebral angiography showed a right fed mainly branches occipital artery well intracavernous internal carotid artery. Embolization...
The aim of this report is to describe 3 cases salivary gland tumors with intracranial extension associated an extracerebral mass lesion, and discuss the frequence, pathology treatment these very rare localizations.The patients were 1 woman 2 men, aged 44, 53 74 years, respectively. primary adenocarcinoma a malignant oncocytoma parotid adenoid cystic carcinoma submandibular gland. location intradural extra-axial tumor was middle fossa temporal region in cerebellopontine angle 1. Surgical...
<h3>Background</h3> Symptomatic spinal gout is relatively rare. Open laminectomy, with or without fusion, has been so far the standard treatment for symptomatic gout. We describe here first case of tophaceus treated minimally invasive surgery. <h3>Methods</h3> A 60-year-old patient, morbidly obese, no previous history gout, presented neurogenic claudication due to severe lumbar canal stenosis at L3/4. Surgery was performed through a approach, using tubular retractors. During surgery, an...
The aim of this study is to evaluate the factors correlated with different patterns (local, peripheral and diffuse) meningioma recurrence.55 patients benign (WHO I) meningiomas which recurred after seemingly complete removal were reviewed; 40 (Group had local or recurrences (< 3 cm from initial dural attachment) 15 II) distant diffuse recurrences. Patient age sex, tumor location, interval recurrence, shape, type brain-tumor interface, histological subtype, mitotic index (MI) progesterone...
Context: Surgery for the rheumatoid cervical spine has been shown to stabilize unstable spine; arrest/improve progression of neurological deficit, help neck pain, and possibly decelerate degenerative disease process. Operative intervention significantly changed over last 30 years. Aims: The purpose this study was review all cases requiring surgical in a single unit Materials Methods: A prospectively-maintained database retrospectively searched spine, leading indications, imaging, Ranawat...
The aim of this study is to evaluate the correlation between expression some growth factors (GFs) and tumor grade, recurrence survival brain glial ependymal tumors.The vascular endothelial factor (VEGF), epidermal receptor (EGFR), tenascine, transforming (TGFbeta), isomeres, platelet-derived (PDGF) p53 was studied in 40 primary tumors, both low-grade high-grade, including astrocytomas, oligodendrogliomas, glioblastomas ependymomas. same GFs were also 46 specimens recurrent tumors from...
Background and Study Aims Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction in elderly population. Surgery usually successful preventing any deterioration, as well improving functional status quality life. This study assesses safety efficacy minimally invasive microscopic posterior cervical decompression for treatment CSM. Materials Methods A retrospective review patients with from stenosis treated was performed. The operation performed through a...
Degenerative cervical myelopathy (DCM) is the commonest cause of adult spinal cord dysfunction worldwide, for which surgery mainstay treatment. At present, there limited literature on costs associated with surgical management DCM, and none from United Kingdom (UK). This study aimed to evaluate cost-effectiveness DCM within National Health Service, UK.