A5101751204- Heme Oxygenase-1 and Carbon Monoxide
- Gut microbiota and health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Arrest and Resuscitation
- Disaster Response and Management
- Muscle and Compartmental Disorders
- Acupuncture Treatment Research Studies
- Advanced Glycation End Products research
- Vagus Nerve Stimulation Research
- Retinoids in leukemia and cellular processes
- Oil Spill Detection and Mitigation
- Body Contouring and Surgery
- Natural Antidiabetic Agents Studies
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Thyroid Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
Xinxiang Medical University
2020-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2011
Chongqing Medical University
2011
First Affiliated Hospital of Kunming Medical University
2011
Kunming Medical University
2011
Shanghai Sixth People's Hospital
2011
Shanghai Jiao Tong University
2011
Dysbiosis of gut microbiota (GM) is intricately linked with cognitive impairment and the incidence traumatic brain injury (TBI) in both animal models human subjects. However, there limited understanding impact mechanisms fecal transplantation (FMT) on barrier function treatment TBI induced by gas explosion (GE). We have employed FMT technology to establish dysbiosis male rats, subsequently conducted non-targeted metabolomics diversity analysis explore bacteria potential functional roles....
Gas explosion can lead to serious global public health issues. Early period gas injury (GEI) induce a series of histopathologic and specific metabolic changes. Unfortunately, it is difficult treat GEI thoroughly. To date, the molecular mechanism still unclear. accurately diagnose provide comprehensive clinical intervention, we performed analysis alterations involved in GEI. The physiological behavioral indicators’ changes rats after were observed. These first investigated rat model using...
Gas explosions are a recurrent event in coal mining that cause severe pulmonary damage due to shock waves, and there is currently no effective targeted treatment. To illustrate the mechanism of gas explosion‑induced lung injury explore strategies for blast (BLI) treatment, present study used BLI rat model supplementation with metformin (MET), an AMP‑activated protein kinase (AMPK) activator, at dose 10 mg/kg body weight by intraperitoneal injection. Protein expression levels were detected...
The objective of this study was to evaluate the histopathological effect gas explosion on rats, and explore metabolic alterations associated with explosion-induced acute blast lung injury (ABLI) in real roadway environment using metabolomics analyses. All rats were exposed source at different distance points (160 m 240 m) except control group. Respiratory function indexes monitored tissue analysis performed correlate serum metabolomics. Their sera samples collected measure by...
In natural disasters such as earthquakes and landslides, the main problem that wounded survivors are confronted with is crush syndrome (CS). The aim of this study was to explore more convenient effective early treatment measures for it. present study, we investigated protective effect fasciotomy combined different concentration hypertonic saline flushing CS rats. model prepared by compressing buttocks both lowering limbs rats 7.5 kg dumbbell 4 h. were divided into 10 groups, which normal...
Objective To study the effect of gas explosion on brain nerve behavior rats in real roadway environment. Methods Before explosion, environment was simulated by using and test system a large coal mine Chongqing Research Institute China Coal Science Technology Group, cage fixation parameter setting were carried out. That to use equivalent 9. 0% containing mixed air install special detonation distance at point 40 m, 160 m 240 m. The SPF grade healthy adult SD male anesthetized with chloral...
Objective: To analyze the changes of serum metabolomics in rats with combined injuries caused by gas explosion and explore its possible mechanism. Methods: In April 2018, large coal mine test roadway system were used to simulate experiment. All 32 SD randomly divided into four groups, control group (not involved explosion) , close range (40 m) group, medium (160 long (240 8 each group. The respiratory function at 2 hours neural behavior 48 detected after explosion. anesthetized sacrificed...
OBJECTIVES: To induce islet-like cells (ILCs) from human embryonic stem (hESCs), and to analyze the dynamic expression of microRNAs (miRNAs) during differentiation.METHODS: ILCs were induced by improved stepwise protocol through definitive endoderm (DE) pancreatic progenitors.Cells in different stages identified RT-PCR, realtime quantitative PCR (qPCR) immunofluorescence staining.The islet specific miRNAs detected via stemloop qPCR adult islets.RESULTS: (i) successfully DE.The suspension...