A5033144598- Inflammasome and immune disorders
- interferon and immune responses
- Muscle Physiology and Disorders
- Cholesterol and Lipid Metabolism
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA modifications and cancer
- Congenital heart defects research
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Circular RNAs in diseases
- Parathyroid Disorders and Treatments
- Mitochondrial Function and Pathology
- Sexual Differentiation and Disorders
- Gastrointestinal Tumor Research and Treatment
- Developmental Biology and Gene Regulation
- Sperm and Testicular Function
- IL-33, ST2, and ILC Pathways
- Estrogen and related hormone effects
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Biomarkers in Disease Mechanisms
- Systemic Lupus Erythematosus Research
Inserm
2012-2024
Physiologie et Médecine Expérimentale du Coeur et des Muscles
2014-2024
Université de Montpellier
2006-2022
Centre National de la Recherche Scientifique
2005-2022
Hôpital Arnaud de Villeneuve
1998-2008
Institut de Génétique Humaine
2005-2007
Institut de Génétique Moléculaire de Montpellier
2000
Familial Mediterranean fever (FMF) is a genetically recessive inflammatory disease caused by mutations in the MEFV gene. Most patients of non-Ashkenazi Jewish ancestry or those who are homozygous for M694V manifest severe course, but some express mild form disease. We therefore searched other genes which could possibly be implicated phenotype. tested MICA (major histocompatibility complex class I chain-related gene A) because it has been associated with number disorders.One hundred fifty FMF...
Abstract Aldehyde dehydrogenases (ALDH) are a family of enzymes that efficiently detoxify aldehydic products generated by reactive oxygen species and might therefore participate in cell survival. Because ALDH activity has been used to identify normal malignant cells with stem properties, we asked whether human myogenic precursor (myoblasts) could be identified isolated based on their levels activity. Human muscle explant‐derived were incubated ALDEFLUOR, fluorescent substrate for ALDH,...
Separately, polyphenols and exercise are known to prevent insulin resistance (IR) but their combined curative effects on established obesity IR require further investigation. Therefore, we compared the metabolic of a combination grape supplementation in obese rats with high-fat diet (EXOPP) effect alone (HF) or nutritional (PP) endurance (EXO) during 8 wks. We observed an improvement systemic skeletal muscle sensitivity EXO EXOPP rats. HF presented lower insulinemia HOMA-IR higher liver...
Abstract In vertebrates, smooth muscle cells (SMCs) can reversibly switch between contractile and proliferative phenotypes. This involves various molecular mechanisms to reactivate developmental signaling pathways induce cell dedifferentiation. The protein RBPMS2 regulates early development plasticity of digestive SMCs by inhibiting the bone morphogenetic pathway through its interaction with NOGGIN mRNA. contains only one RNA recognition motif (RRM) while this is often repeated in tandem or...
Abstract Objective Familial Mediterranean fever (FMF) is the most common inherited periodic syndrome. The disease phenotype and almost exclusive expression of causative gene, MEFV, in leukocytes suggest that this gene plays an important role inflammatory cascade. Since known mutations are conservative, we sought to determine how minor DNA defects can give rise dramatic phenotypic features seen FMF. Methods To address whether molecular basis phenotype–genotype correlation could be related...
Gastrointestinal motility is ensured by the correct coordination of enteric nervous system and visceral smooth muscle cells (SMCs), defective development SMCs results in gut malformations intestinal obstructions. In order to identify molecular mechanisms that control differentiation mesenchyme into vertebrate stomach, we developed microarrays analyze gene expression profiles undifferentiated differentiated avian stomachs. We Scleraxis, a basic-helix-loop-helix transcription factor, as new...
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting following repeated damage and inadequate regeneration. Impaired myogenesis differentiation play a major role in DMD as well intracellular calcium (Ca2+) mishandling. Ca2+ release from the sarcoplasmic reticulum mostly mediated type 1 ryanodine receptor (RYR1) that required for skeletal animals. The study objective was to determine whether altered RYR1-mediated contributes myogenic impairment patients. comparison...
The potential role and function of gastrokine-1 (GNK1) in smooth muscle cells is investigated this work by first establishing a preparative protocol to obtain native protein from freshly dissected chicken gizzard. Some unexpected biochemical properties were deduced producing specific polyclonal antibody against the purified protein. We focused on F-actin interaction with contractile properties. Background GNK1 thought provide mucosal protection superficial gastric epithelium. However, actual...
Medial vascular calcification (MVC) is a highly prevalent disease associated with high risk of severe, potentially lethal, complications. While animal studies may not systematically be circumvented, in vitro systems have been proven useful to study physiopathology. In the context MVC, absence clinically relevant standardized method prevents appropriate comparison and overall interpretation results originating from different experiments. The aim our establish models mimicking vivo select best...
Abstract Deposition of the exon junction complex (EJC) upstream exon-exon junctions helps maintain transcriptome integrity by preventing spurious re-splicing events in already spliced mRNAs. Here we investigate importance EJC for correct splicing 2.2-megabase-long human DMD pre-mRNA, which encodes dystrophin, an essential protein involved cytoskeletal organization and cell signaling. Using targeted RNA-seq, show that knock-down eIF4A3 Y14 core components a muscle line causes accumulation...