A5036080705- Neuroendocrine Tumor Research Advances
- RNA Research and Splicing
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Connective tissue disorders research
- Prostate Cancer Treatment and Research
- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Radiopharmaceutical Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Liver Disease Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Molecular Biology Techniques and Applications
University of Córdoba
2016-2025
Instituto Maimónides de Investigación Biomédica de Córdoba
2016-2025
Hospital Universitario Reina Sofía
2015-2024
Cordoba University
2017-2024
Centro de Investigación Biomédica en Red
2015-2023
Weatherford College
2023
Centre International de Recherche sur le Cancer
2023
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2019-2022
King's College London
2021-2022
Cell and Gene Therapy Catapult
2022
Glioblastomas remain the deadliest brain tumour, with a dismal ∼12-16-month survival from diagnosis. Therefore, identification of new diagnostic, prognostic and therapeutic tools to tackle glioblastomas is urgently needed. Emerging evidence indicates that cellular machinery controlling splicing process (spliceosome) altered in tumours, leading oncogenic events associated tumour progression aggressiveness. Here, we identify for first time profound dysregulation expression relevant spliceosome...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and stem (CSCs). Altered splicing emerging as hallmark an attractive therapeutic target. The core factor SF3B1 heavily altered in can be inhibited by Pladienolide-B, but its actionability PDAC unknown. We explored the presence role of interrogated potential actionable target.SF3B1 was analyzed tissues, RNA-seq dataset, publicly available databases, examining associations...
Biguanides and statins exert beneficial effects on various cancer types. Their precise underlying molecular mechanisms are poorly understood. We analyzed the relationship between metabolic syndrome histological, epidemiological, prognosis variables in two cohorts of patients with neuroendocrine tumors (NETs): those lung carcinoids (LCs; n = 81) gastroenteropancreatic NET (GEP-NET; 100). Biguanide statin antitumor were investigated by evaluating proliferation, migration, secretion, gene...
Objectives To characterise splicing machinery (SM) alterations in leucocytes of patients with rheumatoid arthritis (RA), and to assess its influence on their clinical profile therapeutic response. Methods Leucocyte subtypes from 129 RA 29 healthy donors (HD) were purified, 45 selected SM elements (SME) evaluated by quantitative PCR-array based microfluidic technology (Fluidigm). Modulation anti-tumour necrosis factor (TNF) therapy underlying regulatory mechanisms assessed. Results An altered...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, characterized by late diagnosis and poor treatment response. Surgery the only curative approach, available to early‐diagnosed patients. Current therapies have limited effects, cause severe toxicities, minimally improve overall survival. Understanding of splicing machinery alterations in PDAC remains incomplete. Here, we comprehensively examined 59 components, uncovering dysregulation pre‐mRNA processing factor 8 ( PRPF8 )...
Background Prostate cancer (PCa) is a highly prevalent neoplasia that strongly influenced by the endocrine system. Somatostatin (SST) and its five receptors (sst1‐5 encoded SSTR1‐5 genes) comprise pleiotropic system present in most endocrine‐related cancers, some of which are successfully treated with SST analogs. Interestingly, it has been reported SSTR1 overexpressed PCa, but regulation, functional role, clinical implications still poorly known. Methods PCa specimens ( n = 52) from...
Abstract Background Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly aggressive cancers. Carcinoids are the rarest LungNENs, display low intermediate malignancy and may be surgically managed, but show resistance radiotherapy/chemotherapy in case metastasis. Molecular profiling is providing new information understand lung carcinoids, its clinical value still limited. Altered alternative splicing...
Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the expression/secretion profile of EN2 five independent samples cohorts from PCa patients controls (prostate tissues and/or urine) to determine utility 2) normal (RWPE1) tumor (LNCaP/22Rv1/PC3) explore value therapeutic target. was overexpressed our two compared control cell lines...
Pancreatic neuroendocrine tumors (PanNETs) comprise a heterogeneous group of with growing incidence. Recent molecular analyses provided precise picture their genomic and epigenomic landscape. Splicing dysregulation is increasingly regarded as novel cancer hallmark influencing key tumor features. We have previously demonstrated that splicing machinery markedly dysregulated in PanNETs. Here, we aimed to elucidate the functional implications
Abstract Somatostatin (SST) and cortistatin (CORT) are two highly related neuropeptides involved in the regulation of various endocrine secretions. In particular, SST CORT primary negative regulators GH secretion. Consequently, single or knockout mice exhibit elevated levels; however, this does not lead to increased IGF-1 levels somatic growth. This apparent lack correspondence has been suggested result from compensatory mechanisms between both peptides. To test hypothesis, study we...
Objectives: The association between the presence and alterations of components ghrelin system development progression neuroendocrine tumors (NETs) is still controversial remains unclear. Methods: Here, we systematically evaluated expression levels (by quantitative-PCR) key in gastroenteropancreatic (GEP)-NETs, as compared to non-tumor adjacent (NTA; n = 42) normal tissues (NT; 14). Then, analyzed their putative associations with clinical-histological characteristics. Results: results...
Somatostatin receptor subtype 5 (SST5 ) is an emerging biomarker and actionable target in pituitary (PitNETs) pancreatic (PanNETs) neuroendocrine tumors. Transcriptional epigenetic regulation of SSTR5 gene expression mRNA biogenesis poorly understood. Recently, overlapping natural antisense transcript, SSTR5-AS1, potentially regulating expression, was identified. We aimed to elucidate whether processes contribute the PitNETs (somatotropinomas) PanNETs. analyzed SSTR5/SSTR5-AS1 human locus...
Somatostatin (SST), cortistatin (CORT), and their receptors (SSTR1-5/sst5TMD4-TMD5) comprise a multifactorial hormonal system involved in the regulation of numerous pathophysiological processes. Certain components this are dysregulated play critical roles development/progression different endocrine-related cancers. However, presence therapeutic role regulatory prostate cancer (PCa) remain poorly explored. Accordingly, we performed functional (proliferation/migration/colonies-formation)...