A5026451614- Pituitary Gland Disorders and Treatments
- RNA Research and Splicing
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Microtubule and mitosis dynamics
- Adrenal and Paraganglionic Tumors
- Hypothalamic control of reproductive hormones
- Acute Lymphoblastic Leukemia research
- Mechanisms of cancer metastasis
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Adrenal Hormones and Disorders
- Molecular Biology Techniques and Applications
- Caveolin-1 and cellular processes
- ATP Synthase and ATPases Research
University of Córdoba
2017-2025
Instituto Maimónides de Investigación Biomédica de Córdoba
2017-2025
Cedars-Sinai Medical Center
2024-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2017-2024
Hospital Universitario Reina Sofía
2017-2024
Centro de Investigación Biomédica en Red
2018-2024
Cordoba University
2023
Glioblastomas remain the deadliest brain tumour, with a dismal ∼12-16-month survival from diagnosis. Therefore, identification of new diagnostic, prognostic and therapeutic tools to tackle glioblastomas is urgently needed. Emerging evidence indicates that cellular machinery controlling splicing process (spliceosome) altered in tumours, leading oncogenic events associated tumour progression aggressiveness. Here, we identify for first time profound dysregulation expression relevant spliceosome...
Glioblastoma is one of the most devastating and incurable cancers due to its aggressive behaviour lack available therapies, being overall-survival from diagnosis ∼14-months. Thus, identification new therapeutic tools urgently needed. Interestingly, metabolism-related drugs (e.g., metformin/statins) are emerging as efficient antitumour agents for several cancers. Herein, we evaluated in vitro/in vivo effects metformin and/or statins on key clinical/functional/molecular/signalling parameters...
Abstract Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and factors) aberrant expression of oncogenic splice variants. We aimed to analyze the potential role spliceosome component PRPF8 (pre-mRNA processing factor 8) HCC. (mRNA/protein) was analyzed a retrospective cohort HCC patients ( n = 172 nontumor tissues) validated two silico cohorts (TCGA CPTAC). silenced liver cancer cell lines xenograft tumors understand...
Reproduction is safeguarded by multiple, often cooperative regulatory networks. Kisspeptin signaling, via KISS1R, plays a fundamental role in reproductive control, primarily regulation of hypothalamic GnRH neurons. We disclose herein pathway for direct kisspeptin actions astrocytes that contributes to central modulation. Protein-protein-interaction and ontology analyses proteomic profiles after stimulation revealed glial/astrocyte markers are regulated mice. This glial-kisspeptin was...
Glioblastoma is one of the most devastating cancer worldwide based on its locally aggressive behavior and because it cannot be cured by current therapies. Defects in alternative splicing process are frequent cancer. Recently, we demonstrated that dysregulation spliceosome directly associated with glioma development, progression, aggressiveness.Different human cohorts a dataset from different mouse models were analyzed to determine mutation frequency as well gene protein expression levels...
Pituitary neuroendocrine tumors (PitNETs) constitute approximately 15% of all brain tumors, and most have a sporadic origin. Recent studies suggest that altered alternative splicing and, consequently, appearance aberrant variants, is common feature tumor pathologies. Moreover, spliceosome considered an attractive therapeutic target in pathologies, the inhibition SF3B1 (e.g., using pladienolide-B) has been shown to exert antitumor effects. Therefore, we aimed analyze expression levels...
Abstract Context Pituitary neuroendocrine tumors (PitNETs) are a commonly underestimated pathology in terms of incidence and associated morbimortality. Currently, an appreciable subset patients resistant or poorly responsive to the main current medical treatments [i.e., synthetic somatostatin analogs (SSAs) dopamine agonists]. Thus, development optimization novel available therapies is necessary. Biguanides (metformin, buformin, phenformin) antidiabetic drugs that exert antitumoral actions...
Carcinoid heart disease (CHD) is a frequent and life-threatening complication in patients with carcinoid tumors. Its clinical management challenging some cases since serotonin-induced valve fibrosis leads to failure. Telotristat an inhibitor of tryptophan-hydroxylase (TPH), key enzyme serotonin production. use syndrome uncontrollable diarrhea under somatostatin analogs approved, but its specific role CHD still not clear. IN this context, we aimed explore the effect telotristat using mouse...
Heterotrimeric extracellular matrix proteins laminins are mostly deposited at basal membranes and important in repair neoplasia. Here, we localize laminin beta 2 ( LAMB2) the sites of blood–brain barrier (BBB). Microvasculature (MV) normal brain is endowed with complete LAMB2 coverage. In contrast, its cognate protein 1 LAMB1) absent MV but emerges sprouting tip a growing vessels. Similarly, vascular proliferation high-grade gliomas (HGG) accompanied by marked overexpression LAMB1, whereas...
Despite novel therapeutic strategies, advanced-stage prostate cancer (PCa) remains highly lethal, pointing out the urgent need for effective strategies. While dysregulation of splicing process is considered a hallmark, role certain factors unknown in PCa. This study focuses on characterizing levels and SRSF6 this disease. Comprehensive analyses alterations (copy number/mRNA/protein) were conducted across eight well-characterized PCa cohorts Hi-MYC transgenic model. was up-regulated samples,...
Abstract Context Prostate cancer (PCa) is one of the leading causes cancer-related death among male population worldwide. Unfortunately, current medical treatments fail to prevent PCa progression in a high percentage cases; therefore, new therapeutic tools tackle are urgently needed. Biguanides and statins have emerged as antitumor agents for several endocrine-related cancers. Objective To evaluate: (1) putative vivo association between metformin and/or treatment key tumor clinical...
Pituitary neuroendocrine tumors (PitNETs) represent approximately 15% of all intracranial and usually are associated with severe comorbidities. Unfortunately, a relevant number patients do not respond to currently available pharmacological treatments, that is, somatostatin analogs (SSAs) or dopamine-agonists (DA). Thus, novel, chimeric somatostatin/dopamine compounds (dopastatins) could improve medical treatment PitNETs have been designed.This study aims determine the direct therapeutic...
Pituitary neuroendocrine tumors (PitNETs), the most abundant of all intracranial tumors, entail severe comorbidities. First-line therapy is transsphenoidal surgery, but subsequent pharmacological often required. Unfortunately, many patients are/become unresponsive to available drugs (somatostatin analogues [SSAs]/dopamine agonists), underscoring need for new therapies. Statins are well-known commonly prescribed treat hyperlipidemia/cardiovascular diseases, can convey additional beneficial...
Pituitary adenomas (PAs) are intracranial tumors, often associated with excessive hormonal secretion and severe comorbidities. Some patients resistant to medical therapies; therefore, novel treatment options needed. Antagonists of growth hormone-releasing hormone (GHRH) exert potent anticancer effects, early GHRH antagonists were found inhibit GHRH-induced pituitary GH in vitro vivo. However, the antitumor role PAs is largely unknown. Here, we show that MIAMI class, MIA-602 MIA-690,...
Abstract A significant proportion of infant B-cell acute lymphoblastic leukemia (B-ALL) patients remains with a dismal prognosis due to yet undetermined mechanisms. We performed comprehensive multicohort analysis gene expression, fusions, and RNA splicing alterations uncover molecular signatures potentially linked the observed poor outcome. identified 87 fusions allele frequency across shared functional impacts, suggesting common mechanisms fusions. further expression signature that predicts...