A5062862848- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Hormonal and reproductive studies
- Vitamin D Research Studies
- Bone health and treatments
- Bone health and osteoporosis research
- Pharmacology and Obesity Treatment
- Sexual function and dysfunction studies
- Electrolyte and hormonal disorders
- Muscle metabolism and nutrition
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Sexual Differentiation and Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neuroendocrine Tumor Research Advances
- Hypothalamic control of reproductive hormones
- Parathyroid Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Lipid metabolism and disorders
- Asthma and respiratory diseases
Postgraduate School of Molecular Medicine
2014-2024
Grochowski Hospital
2010-2023
Centrum Medyczne Kształcenia Podyplomowego
2007-2022
Provincial Polyclinical Hospital in Toruń
2015
Centralny Szpital Kliniczny
2015
Institute for Postgraduate Medical Education
2007-2014
Patients with Addison's disease (AD) self-report impairment in specific dimensions on well-being questionnaires. An AD-specific quality-of-life questionnaire (AddiQoL) was developed to aid evaluation of patients. We aimed translate and determine construct validity, reliability, concurrent validity the AddiQoL questionnaire. After translation, final versions were tested AD patients from Norway (n = 107), Sweden 101), Italy 165), Germany 200), Poland 50). Construct examined by exploratory...
Delay of diagnosis primary adrenal insufficiency (PAI) leads to crisis which is potentially lethal complication. The objective our work was an assessment whether the establishment adrenocortical in Poland so much delayed as assessed past. We have analysed data from 60 patients with PAI established department during past 12 years and who are still under care. found that time exceeds 3 months every patient 6 admitted symptoms crisis. Forty-four percent were diagnosed only just after...
This study was aimed at summarizing our experience in the management of 1 444 patients with incidentally found adrenal tumors observed a single endocrinological centre. Hormonal determinations were performed all beginning observation period to detect subclinical hyperfunction. The imaging phenotype on CT and MRI analyzed for defining malignant potential tumors. Based results these examinations we diagnosed among cohort probably benign masses 87%, 10% (adrenal carcinoma - 9%), metastases 3%....
Primary aldosteronism (PA) is estimated to occur in 5–12% of patients with hypertension. Assessment aldosterone / plasma renin activity (PRA) ratio (ARR) has been used as a screening test suspected PA. Direct determination (DRC) and calculation direct concentration (ADRR) could be similarly useful for The study included 62 indication evaluation the renin-angiotensin-aldosterone system 35 healthy volunteers. In all participants we measured concentrations serum aldosterone, renin, PRA after...
The aim of this study was to investigate the incidence hypogonadotropic hypogonadism (HH) in type 2 diabetic men (T2DM) population Polish and examine possible influence estradiol levels glycemic control. We evaluated TT, cfT, estradiol, control (HbA1c) 184 149 nondiabetic group. mean HbA1c 8.6 ± 0.2% 6.1 0.3% cfT concentration 0.315 0.08 nmol/L 0.382 0.07 nmol/L, respectively. T2DM had higher E2 than nonobese (29.4 3.7 pg/mL versus 24.5 2.9 pg/mL). Forty-six percent were hypogonadal 93% HH....
Objective: Prediabetes patients are likely to develop type 2 diabetes (T2DM). Low testosterone is a risk factor for impaired glucose tolerance (IGT) in men. The aim of this study was investigate the prevalence prediabetes population Polish men with late-onset hypogonadism (LOH).Methods: This performed 246 LOH and 184 eugonadal control group. diagnosed fasting (IFG), IGT or HbA1c from 5.7 6.4%. Sex hormones metabolic parameters were measured.Results: mean TT concentration group 9.55 ± 1.5...
Adrenal scintigraphy with 131I-6β-iodomethylnorcholesterol is considered by several authors the gold standard for assessing tumors subclinical hypercortisolemia. However, most of described series consist mainly cases unilateral lesions. The aim our study was to assess whether useful in choosing adrenalectomy side case bilateral adrenal hypercortisolemia.The focused on 15 consecutive patients benign and performed. Fourteen underwent adrenalectomy; gland predominant uptake removed. Cortisol...
Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) are common in diabetic men. The aim of this study was to investigate hormonal determinants, the prevalence severity ED LUTS middle-aged elderly men with prediabetes (PD).We investigated 176 PD 184 healthy peers. defined according American Diabetes Association. IIEF scale IPSS were assessed. Total testosterone (TT), calculated free (cFT), dehydroepiandrosterone sulfate (DHEAS) insulin-like growth factor 1 (IGF-1) measured.The...
Advances in the diagnosis and treatment of adrenocortical carcinoma (ACC), along with development new therapeutic diagnostic methods, have prompted a team experts to formulate first Polish guidelines for managing ACC. This article presents recommendations resulting from discussion specialists various medical specialities, who participated series online meetings aimed at developing consistent effective under National Oncology Strategy. These aim optimise ACC Poland through coordinated efforts...
Objectives: Around 40% of diabetic men have lowered testosterone and symptoms hypogonadism but the prevalence among prediabetic is unknown. The aim this study was to investigate late-onset (LOH) in population Polish with prediabetes.
KEy wORdsadrenocortical carcinoma
Adrenal gland is a common site of metastasis and on the other hand, metastases are most frequent malignant adrenal tumors. The aim this study was to estimate risk malignancy in suspicious mass patients with history cancer.This single-center retrospective analysis tumors treated previously for different types cancers. Between 2004 2021 hundred six such were identified. Mean age 62.6 years (30-78), mean time from oncologic treatment 55.8 months (0-274). primary cancer kidney (RCC): 29 (27.4%),...
Objectives: Erectile dysfunctions (EDs) are in part caused by hormonal causes; but men over 65 years of age, testosterone deficiency seems to play an important role. However, population Polish age with relative poor health status, the prevalence patients ED is unknown. Material and methods: 286 EDs were invited complete erectile function questionnaire (IIEF-5), as a diagnostic tool for EDs. Serum total (TT) levels measured. Linear regression model was used analyze factors that associated...
Severe Cushing's syndrome (SCS) is associated with acute cardiovascular, metabolic and infectious complications. It considered an emergency, requiring immediate diagnosis, together a broad spectrum of supportive hypocortisolaemic treatments. Surgical intervention, aimed at removing the source cortisol or adrenocorticotropic hormone (ACTH), optimal treatment in most cases syndrome. However, hypercortisolaemic states, surgical intervention has high rates perioperative mortality morbidity. Oral...
Dehydroepiandrosterone (DHEA) concentration decreases with age, therefore, DHEA has been considered a hormone that reduces the symptoms associated aging, so usefulness of in premenopausal and postmenopausal women, options therapy have received large amount attention. The effectiveness women remains unclear, while coexisting estrogens deficiency is controversial. Despite many years study, use still controversial, especially regarding its effectiveness. aim present article was to evaluate...
Andropausal and depressive symptoms are common in aging males may be associated with hormone deficiency. We investigated the severity of andropausal symptoms, as well their hormonal determinants, 196 middle-aged elderly men (age range: 40-80 years) prediabetes (PD) 184 healthy peers. PD was diagnosed according to definition American Diabetes Association. The assessed using Aging Males' Symptoms Rating Scale Self-Rating Depression Scale. Total testosterone (TT), calculated free (cFT),...
Introduction: Performing measurements of plasma renin activity (PRA) or direct concentration (DRC) and aldosterone concentration, we should be well informed about requirements concerning blood sample processing. Material methods: Forty-seven patients had collected in the supine upright positions. Blood was withdrawn into two EDTA2K tubes one with clot activator. One tube cooled at +4°C centrifuged whereas other prepared room temperature. PRA DRC were measured by radioimmunoassay (RIA)...
Prediabetes (PD) leads to reduced testosterone (T) in males, but the association between anabolic hormones and bone mineral density (BMD) remains unknown.We investigated an BMD middle-aged elderly men with PD.We 84 prediabetic 56 control men. Total T (TT), calculated free (cFT), dehydroepiandrosterone sulfate (DHEAS) were measured, was assessed using DXA methods.Patients PD had lower TT (p < .001), cFT .005), DHEAS .02) than group. values of lumbar spine total body .05) Lumbar correlated (r...
According to some authors, a higher incidence of subclinical hypercortisolemia is found among patients with bilateral benign adrenal tumors than in those unilateral tumors. It still unknown whether all and should undergo surgery, and, if so, which tumor be removed first.The aim the study was investigate adrenalectomy can lead resolution improvement their clinical status.The group consisted 25 hypercortisolemia. In 24 patients, performed. The gland selected for removal on basis scintigraphy...