A5046123873- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Magnesium in Health and Disease
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Antioxidant Activity and Oxidative Stress
- Muscle metabolism and nutrition
- Metabolomics and Mass Spectrometry Studies
- Trace Elements in Health
- Plant Micronutrient Interactions and Effects
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Cholesterol and Lipid Metabolism
- Sirtuins and Resveratrol in Medicine
- Parathyroid Disorders and Treatments
- Iron Metabolism and Disorders
- Heavy Metal Exposure and Toxicity
- Microbial Metabolites in Food Biotechnology
- Edible Oils Quality and Analysis
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Free Radicals and Antioxidants
- Metabolism and Genetic Disorders
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2004-2025
Dynamique Musculaire et Métabolisme
2013-2024
Université de Montpellier
2011-2023
Institut Agro Montpellier
2012-2021
Centre Hospitalier Universitaire de Montpellier
2021
Institut National de la Recherche Agronomique
1999-2019
Institut Universitaire de Recherche Clinique
2010
Immunology from Concept and Experiments to Translation
2009
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2005-2006
Centre de Recherche en Nutrition Humaine Rhône-Alpes
2005-2006
To assess the clinical efficacy of nutritional amounts grape polyphenols (PPs) in counteracting metabolic alterations high-fructose diet, including oxidative stress and insulin resistance (IR), healthy volunteers with high risk.Thirty-eight overweight/obese first-degree relatives type 2 diabetic patients (18 men 20 women) were randomized a double-blind controlled trial between PP (2 g/day) placebo (PCB) group. Subjects investigated at baseline after 8 9 weeks supplementation, last 6 days...
Chicoric acid (CA) is a caffeoyl derivative previously described as having potential anti-diabetic properties. As similarities in cellular mechanism between diabetes and aging have been shown, we explored on L6 myotubes the effect of CA modulation intracellular pathways involved aging. We also determined its influence lifespan Caenorhabditis elegans worm (C. elegans). In myotubes, was potent reactive oxygen species (ROS) scavenger, reducing ROS accumulation under basal well oxidative stress...
Dietary lipids are known to affect the composition of biological membrane and functions that involved in cell death survival. The mitochondrial respiratory chain enzymes protein complexes whose function depends on fluidity lipid. present study aimed at investigating impact different nutritional patterns dietary liver functions. A total forty-eight Wistar male rats were divided into six groups fed for 12 weeks with a basal diet, lard diet or fish oil containing either 50 300 g lipid/kg. 30 %...
The prevalence of metabolic syndrome (MetS) components including obesity, dyslipidemia, insulin resistance (IR), and hepatic steatosis is rapidly increasing in wealthy societies. It accepted that inflammation/oxidative stress are involved the initiation/evolution MetS features. present work was designed to evaluate effects three major cellular ROS production systems on glucose tolerance, development oxidative onset. To do so, 40 young male Sprague–Dawley rats were divided into 5 groups:...
Natural deep eutectic solvents (NaDES) are new natural in green chemistry that some cases have been shown to allow better extraction of plant bioactive molecules compared conventional and higher phenolic compound absorption rodents. However, there is a serious lack information regarding their vivo safety. The purpose this study was verify the safety NaDES (betaine:glycerol (1:2 mole ratio) water) extract from coffee beans, rich polyphenols. Twelve 6-week-old male Wistar rats were randomized...
Inflammation and oxidative stress are thought to be involved in, or associated with, the development of obesity, dyslipidemia, hepatic steatosis, insulin resistance. This work was designed determine evolution inflammation during onset progression steatosis glucose intolerance. Seventy-five male Wistar rats were divided control high-fat high-fructose (HFHFr) groups. A subgroup each group sacrificed at 4, 8, 12, 16, 20 weeks. HFHFr-fed exhibited overweight, intolerance, with increased contents...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common form of chronic disease, for which only resmetirom has recently received FDA approval. Prevention crucial, as it can help manage and potentially reverse progression MAFLD to more severe stages. Omega-3 acids, are a type polyunsaturated acid (PUFA), have numerous beneficial effects in health including disease. Other bioactive lipids, such furanic acids (FuFA) hydroxy esters (FAHFA), also demonstrated several...
Abstract Background previous studies have shown that non-digestible inulin-type fructan intake can increase intestinal mineral absorption in both humans and animals. However, this stimulatory effect on may depend experimental conditions such as duration of fermentable fiber intake, diet levels animals' physiological status, particular their age. Objectives the aim study was to determine inulin Ca Mg rats at different age stages. Methods eighty male Wistar four ages (2, 5, 10 20 months) were...
Loss of myostatin (mstn) function leads to a decrease in mitochondrial content, reduced expression cytochrome c oxidase, and lower citrate synthase activity skeletal muscle. These data suggest functional or ultrastructural abnormalities that can impact on muscle endurance characteristics such phenotype. To address this issue, we investigated subsarcolemmal intermyofibrillar (IMF) activities, redox homeostasis, fiber quality mstn-deficient mice [mstn knockout (KO)]. We report lack mstn...
Abstract The prevalence of the metabolic syndrome components including abdominal obesity, dyslipidaemia and insulin resistance is increasing in both developed developing countries. It generally accepted that development these features preceded by, or accompanied with, impaired mitochondrial function. present study was designed to analyse effects a mitochondrial-targeted lipophilic ubiquinone (MitoQ) on muscle lipid profile modulation function obesogenic diet-fed rats. For this purpose,...
Thyroid hormone is a major determinant of energy expenditure and key regulator mitochondrial activity. We have previously identified triiodothyronine receptor (p43) that acts as transcription factor the organelle genome, which leads, in vitro vivo, to stimulation biogenesis. Here we generated mice specifically lacking p43 address its physiological influence. found required for normal glucose homeostasis. The p43−/− had defect insulin secretion both vivo isolated pancreatic islets loss...
High-fat or high-fat–high-sucrose diets are known to induce non-alcoholic fatty liver disease and this is emerging as one of the most common diseases worldwide. Some polyphenols have been reported decrease rat hepatic lipid accumulation, in particular those extracted from red grapes such resveratrol. The present study was designed determine whether a polyphenol extract (PPE), grapes, modulates acid composition desaturase activity indexes rats fed (HFHS) diet, explore sirtuin-1 deacetylase...
The incidence of metabolic syndrome components including obesity, lipid deregulation, insulin resistance (IR) and non-alcoholic fatty liver disease is increasing rapidly in wealthy societies. present study was designed to determine the effect different nutritional patterns (quantity quality) on utilisation oxidative stress muscle rats an integrated fashion. A total forty-eight Wistar male were fed for 12 weeks with a mixed, lard or fish-oil diet, containing either 50 300 g lipid/kg. Rats...
Abstract The incidence of obesity and its metabolic complications are rapidly increasing become a major public health issue. This trend is associated with an increase in the prevalence non-alcoholic fatty liver disease (NAFLD), insulin resistance diabetes. sequence events leading to NAFLD progression mitochondrial dysfunction their interrelation remains be elucidated. study aimed explore installation association structure activity changes rats fed obesogenic diet up 20 weeks. Male Wistar...
Pentadecanoic acid (C15:0) and heptadecanoic (C17:0) have been described as dietary biomarkers of dairy-fat consumption, with varying degrees reliability between studies. It remains unclear how the total amount fat, representing one main confounding factors in these biomarker investigations, affects C15:0 C17:0 circulating concentrations independent their relative intake. Additionally, it is not clear changes total-fat other fatty acids circulation. Through two studies different levels but...