A5090295856- Infant Nutrition and Health
- Pediatric health and respiratory diseases
- Cell death mechanisms and regulation
- Digestive system and related health
- Influenza Virus Research Studies
- Diabetes and associated disorders
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Breastfeeding Practices and Influences
- S100 Proteins and Annexins
- Sepsis Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Antioxidants, Aging, Portulaca oleracea
- Tryptophan and brain disorders
- Cancer, Lipids, and Metabolism
- Multiple Sclerosis Research Studies
- Helicobacter pylori-related gastroenterology studies
- RNA Research and Splicing
- Neonatal and Maternal Infections
- Autophagy in Disease and Therapy
- Plant biochemistry and biosynthesis
- Studies on Chitinases and Chitosanases
- Educational Technology and Assessment
- Angiogenesis and VEGF in Cancer
- interferon and immune responses
Hubei University of Chinese Medicine
2016-2023
Second Hospital of Shandong University
2022
Utrecht University
2017-2021
First Affiliated Hospital of Henan University
2018
Tianjin University of Science and Technology
2009-2015
Development of Type 1 diabetes (T1D) is influenced by non-genetic factors, such as optimal microbiome development during early life that "programs" the immune system. Exclusive and prolonged breastfeeding an independent protective factor against T1D, likely via bioactive components. Human Milk Oligosaccharides (HMOS) are microbiota modulators, known to regulate responses directly. Here we show provision (only for a period six weeks) 1% authentic HMOS (consisting both long-chain, well...
Human milk oligosaccharides (HMOS) are a complex mixture of bioactive components supporting the immune development breastfed-infants. Dendritic cells (DCs) play central role in regulation responses, being specialized antigen presentation and driving T-cell priming as well differentiation. However, little is known about direct effects HMOS on human DC phenotypes functions. Here, we report that isolated from pooled milk, induced semi-maturation monocytes-derived DCs (moDCs), elevated levels...
Background: Human milk is uniquely suited to provide optimal nutrition and immune protection infants. oligosaccharides (HMOS) are structural complex diverse consisting of short chain long typically present in a 9:1 ratio. 2'-Fucosyllactose (2'FL) one the most prominent associated with anti-infective capacity human milk. Aim: To determine effect 2'FL on vaccination responsiveness (both innate adaptive) murine influenza model elucidate mechanisms involved. Methods: A dose range 0.25-5% (w/w)...
A critical role for host-microbe interactions and establishment of vaccine responses has been postulated. Human milk oligosaccharides, which 2'-fucosyllactose (2'FL) is the most prevalent, are known to alter host-associated microbial communities play a in immunologic development breastfed infants.
Our previous study showed that interferon gamma (IFN-γ) might enhance the immunosuppressive properties of mesenchymal stem cells (MSCs) by upregulating expression indoleamine 2,3-dioxygenease. Therefore, we treated experimental autoimmune encephalomyelitis (EAE) mice, an animal model multiple sclerosis (MS), with IFN-γ-primed human umbilical cord MSCs (IFN-γ-hUCMSCs). This aimed to investigate potential therapeutic effects IFN-γ-hUCMSCs transplantation and identify biological pathways...
Traditional Chinese medicine injections (TCMIs) have been widely used to treat severe and acute diseases due their high bioavailability, accurate curative effect, rapid effect. However, incidence rates of adverse drug reactions (ADRs) TCMIs also increased in recent years. Xueshuantong injection (XSTI) is a commonly-used TCMI comprised Panax notoginseng total sapiens for the treatment stroke hemiplegia, chest pain, central retinal vein occlusion. Its safety remains uncelar. Therefore,...
Inflammation is the predominant characteristic of pneumonia. The present study aimed to identify a faster and more reliable novel inflammatory marker for diagnosis expression S100A12 gene was analyzed by reverse transcription quantitative polymerase chain reaction in samples obtained from 46 patients with bacterial pneumonia other infections, compared 20 healthy individuals, using 2‑ΔΔCt method. levels were increased 12 Compared clinical data, positive correlation observed between white...
During a specific milk fermentation process with Bifidobacterium breve C50 and Streptococcus thermophilus 065 (LactofidusTM), postbiotics possible immunomodulatory properties are produced. We investigated the effects of this product (FP) in vitro using model that allows crosstalk between intestinal epithelial (IEC) immune cells. IECs were exposed to FP αCD3/CD28-activated peripheral blood mononuclear cells after which mediator secretion was measured. Additionally, murine influenza...
Granzyme B (GrB) is a serine protease that expressed in the lytic granules of natural killer (NK) cells and cytotoxic T lymphocytes (CTL), which has been widely reported to serve crucial role for target cell apoptosis. GrB may non‑cytotoxic inflammation, but evidence remains unclear. The present study aimed establish an inflammatory model by using NK92 stimulated with lipopolysaccharide (LPS) investigate whether was involved development inflammation. extracellular levels tumor necrosis...
ObjectiveThis study aimed to explore whether acupuncture and moxibustion can enhance the immune response by increasing expression of endogenous adjuvant HSP70 mRNA.MethodForty Wistar rats were divided into four groups: model group (A), control (B), normal (C), (D). Model groups A B induced injecting d-galactose for 6 weeks. Rats in C then treated with low-frequency electroacupuncture (EA) at Zusanli (ST36), Guanyuan (CV4), Baihui (GV20) 3 Subsequently, all observed 2 more At 12th week,...
Objective To investigate the effect of ulinastatin on miR-21/p38 mitogen-activated protein kinase (p38MAPK) signaling pathway in sepsis. Methods SPF BALB/c mice (n=30) were randomly divided into 3 groups (n=10, each group): LPS group (LPS 10 mg/kg disposable intraperitoneal injection), UTI (Ulinastatin 105 U/kg was pretreated by injection for 2 hours, and administered intraperitoneally mg/kg), normal (same volume saline injected at same time point). After 24 h, sacrificed pathological...