A5068180659- Chromatin Remodeling and Cancer
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Retinal Development and Disorders
- Cellular transport and secretion
- Developmental Biology and Gene Regulation
- Olfactory and Sensory Function Studies
- Civil and Structural Engineering Research
- Genomic variations and chromosomal abnormalities
- Concrete Corrosion and Durability
- Nerve injury and regeneration
- Cancer Mechanisms and Therapy
- Structural Engineering and Materials Analysis
- Circular RNAs in diseases
- Cancer-related gene regulation
- Calcium signaling and nucleotide metabolism
- Hedgehog Signaling Pathway Studies
- Neurogenetic and Muscular Disorders Research
University of Göttingen
2008-2022
Deutsches Institut für Bautechnik (Germany)
2010
Neurogenesis is a key developmental event through which neurons are generated from neural stem/progenitor cells. Chromatin remodeling BAF (mSWI/SNF) complexes have been reported to play essential roles in the neurogenesis of central nervous system. However, whether required for neuron generation olfactory system unknown. Here, we identified onscBAF and ornBAF complexes, specifically present stem cells (oNSCs) receptor (ORNs), respectively. We demonstrated that BAF155 subunit highly expressed...
During early cortical development, neural stem cells (NSCs) divide symmetrically to expand the progenitor pool, whereas, in later stages, NSCs asymmetrically self-renew and produce other cell types. The timely switch from such proliferative differentiative division critically determines neuron numbers. However, mechanisms that limit late development are not fully understood. Here, we show BAF (mSWI/SNF) complexes restrict competence promote neuronal differentiation corticogenesis....
Fusion between membranes is mediated by specific SNARE complexes. Here we report that fibroblasts survive the absence of trans-Golgi network/early endosomal vti1a and late vti1b with intact organelle morphology minor trafficking defects. Because are only members their subclass yeast homolog Vti1p essential for cell survival, these data suggest more distantly related SNAREs acquired ability to function in traffic during evolution. However, resulted perinatal lethality. Major axon tracts were...
The abundance of basal progenitors (BPs), radial glia (bRGs) and intermediate (bIPs), in primate brain has been correlated to the high degree cortical folding. Here we examined role BAF155, a subunit chromatin remodeling BAF complex, generation progenitor heterogeneity. conditional deletion BAF155 led diminished bIP pool increased number bRGs, due delamination apical RGs. We found that is required for normal activity neurogenic transcription factor PAX6, thus controlling expression genes are...
The multi-subunit chromatin-remodeling SWI/SNF (known as BAF for Brg/Brm-associated factor) complexes play essential roles in development. Studies have shown that the loss of individual subunits often affects local chromatin structure and specific transcriptional programs. However, we do not fully understand how function development because no animal mutant had been engineered to lack entire complexes. Importantly, recently reported double conditional knock-out (dcKO) BAF155 BAF170 core mice...
Fine-tuned gene expression is crucial for neurodevelopment. The program tightly controlled at different levels, including RNA decay. N6-methyladenosine (m6A) methylation-mediated degradation of essential brain development. However, m6A methylation impacts not only stability, but also other metabolism processes. How decay contributes to development largely unknown. Here, we show that Exosc10, a exonuclease subunit the exosome complex, indispensable forebrain We report cortical cells undergo...
Increase in the size of human neocortex―acquired evolution―accounts for unique cognitive capacity humans. This expansion reflects evolutionarily enhanced proliferative ability basal progenitors (BPs), including radial glia and intermediate (bIPs) mammalian cortex, which may have been acquired through epigenetic alterations BPs. However, how epigenome BPs differs across species is not known. Here, we report that histone H3 acetylation a key regulation bIP amplification cortical expansion....
Radial neuronal migration is a key neurodevelopmental event indispensable for proper cortical laminar organization. Cortical neurons mainly use glial fiber guides, cell adhesion dynamics, and cytoskeletal remodeling, among other discrete processes, to radially trek from their birthplace final layer positions. Dysregulated radial can engender mis-lamination, leading disorders. Epigenetic factors, including chromatin remodelers have emerged as formidable regulators of corticogenesis. Notably,...
Abstract Neurotrophic factors are well‐recognized extracellular signaling molecules that regulate neuron development including neurite growth, survival and maturation of neuronal phenotypes in the central peripheral nervous system. Previous studies have suggested TGF‐β plays a key role regulation death potentiates neurotrophic activity several factors, most strikingly GDNF. To test physiological relevance this finding, TGF‐β2/GDNF double mutant (d‐ko) mice were generated. Double die at birth...
Intermediate progenitor cells (IPCs) are neocortical neuronal precursors. Although IPCs play crucial roles in corticogenesis, their molecular features remain largely unknown. In this study, we aimed to characterize the profile of IPCs. We isolated TBR2-positive (+) and TBR2-negative (−) cell populations developing mouse cortex. Comparative genome-wide gene expression analysis TBR2+ versus TBR2− revealed differences key factors involved chromatid segregation, cell-cycle regulation,...
Early forebrain patterning entails the correct regional designation of neuroepithelium, and appropriate specification, generation, distribution neural cells during brain development. Specific signaling transcription factors are known to tightly regulate dorsal telencephalon afford proper structural/functional cortical arealization morphogenesis. Nevertheless, whether how changes chromatin structure link transcriptional program(s) that control remains elusive. Here, we report BAF remodeling...
ABSTRACT Increase in the size of human neocortex, acquired evolution, accounts for unique cognitive capacity humans. This expansion appears to reflect evolutionarily-enhanced proliferative ability basal progenitors (BPs) mammalian cortex, which may have been through epigenetic alterations BPs. However, whether or how epigenome BPs differs across species is not known. Here, we report that histone H3 acetylation a key regulation BP amplification and cortical expansion. Through profiling sorted...