A5076065197- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Irish and British Studies
- Prostate Cancer Treatment and Research
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Immunotherapy and Immune Responses
- Migration, Refugees, and Integration
- Religious Education and Schools
- T-cell and B-cell Immunology
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Employment and Welfare Studies
- Religion and Society Interactions
- Migration, Policy, and Dickens Studies
- Romani and Gypsy Studies
- Historical Studies of British Isles
- Migration, Health and Trauma
- Allergic Rhinitis and Sensitization
- Antimicrobial Peptides and Activities
- Complement system in diseases
- Histiocytic Disorders and Treatments
- Genetic Syndromes and Imprinting
Université de Nîmes
2020-2024
Université de Montpellier
2023
University of Lausanne
2018-2023
Biopredic (France)
2003-2018
Centre Hospitalier privé Saint Grégoire
2018
Centre Hospitalier Universitaire de Nîmes
2018
University College Dublin
2006-2014
Université Claude Bernard Lyon 1
2008-2012
Assistance Publique – Hôpitaux de Paris
2011-2012
Universitat Autònoma de Barcelona
2012
DNA methylation patterns were evaluated during preimplantation mouse development by analyzing the binding of monoclonal antibody to 5-methylcytosine (5-MeC) on metaphase chromosomes. Specific chromosome observed in each cell stage. A banding pattern predominated chromosomes at one-cell Banding was replaced two-cell stage an asymmetrical labeling sister chromatids. Then, proportion decreased one-half division until blastocyst stage, and became progressively symmetrical weakly labeled. Our...
Hereditary multiple exostoses (HME) is a genetically heterogeneous human disease characterized by the development of bony outgrowths near ends long bones. HME results from mutations in EXT1 and EXT2, genes that encode glycosyltransferases synthesize heparan sulfate chains. To study relationship to these genes, we generated Ext2-null mice gene targeting. Homozygous mutant embryos developed normally until embryonic day 6.0, when they became growth arrested failed gastrulate, pointing early...
Abstract Prostate cancer is the leading form of in men. tumors often contain neuroendocrine differentiation, which correlates with androgen-independent progression and poor prognosis. Matrix metalloproteinases (MMP), a family enzymes that remodel microenvironment, are associated tumorigenesis metastasis. To evaluate MMPs during metastatic prostatic development, we used transgenic mice expressing SV40 large T antigen their cells, under control transcriptional regulatory elements from mouse...
This study reports on six cases of deficiency in the human complement regulatory protein Factor H (FH) context an acute renal disease. Five were observed children presenting with idiopathic hemolytic uremic syndrome (HUS). Two exhibited a homozygous characterized by absence 150-kD form and presence, upon immunoblotting, 42-kD H-like 1 (FHL-1) other FH-related (FHR) bands. Southern blot PCR analysis DNA one patient ruled out presence large deletion FH gene as underlying defect for deficiency....
National and religious identification processes can be seen as the basis of conflict in Northern Ireland, over course preferred social political identities became increasingly oppositional entrenched. This paper reviews this evidence using population‐level studies self‐categorized national identity. In an attempt to explore bases these identities, two interrelated qualitative examining constructions are reported. The findings presented suggest continuing predominance that have generally been...
Preface This is the report of fifty-first a series workshops organised by European Centre for Validation Alternative Methods (ECVAM). The main objective ECVAM, as defined in 1993 its Scientific Advisory Committee, to promote scientific and regulatory acceptance alternative methods which are importance biosciences, reduce, refine or replace use laboratory animals. One first priorities set ECVAM was implementation procedures that would enable it become well informed about state art non-animal...
Merkel cells (MCs) associated with nerve terminals constitute MC-neurite complexes, which are involved in slowly-adapting type I mechanoreception. Although MCs known to express voltage-gated Ca2+ channels and hypotonic-induced membrane deformation is lead transients, whether initiate mechanotransduction currently unknown. To answer this question, rat were transfected a reporter vector, enabled their identification.Their properties investigated through electrophysiological studies....
This paper examines the evolution of state-supported denominational education system in Ireland context increasing social diversity, and considers capacity for incremental change a institutional pluralism hitherto dominated by single religion. In particular, we examine challenges to historical arrangements emerging two recent contentious issues: cuts special funding Protestant secondary schools proposed diversification patronage primary schools, revealing pressures on dominant role Catholic...
Theories of nationality pose a paradox. Given the possibilities identity plurality and shift, why is ethno-national so deeply embedded prone to produce conflict? Working with in-depth interviews in Northern Ireland, this article illustrates some typical mechanisms change national identity. It shows that identification compatible identities, such identities possible but costly for individuals, content more frequent often important politically than category. greater frequency ease...
Merkel cells (MCs) are involved in mechanoreception, but several lines of evidence suggest that they may also participate skin disorders through the release neuropeptides and hormones. In addition, MC hyperplasias have been reported inflammatory diseases. However, neither proliferation nor reactions to epidermal environment demonstrated. We established a culture model enriched swine MCs analyze their proliferative capability discover survival factors modulators neuroendocrine properties....
This study emphasizes the interest to set up relevant <italic>in vitro</italic> models using human hepatic cells evaluate hepatotoxicity of nanomedicines.
Current understanding of the motivations young people who engage in paramilitary activity is poor. The youth bulge literature has made important advances determinants political violence at population level; however, psychological processes that underpin engagement with among are less clearly understood. Further, pathologization terrorist hampered deeper those seek to effect change using violence. This article explores explanations offered by 14—16-year-olds regarding possible activities...
The Good Friday Agreement of 1998 gave an opportunity to remake not just political institutions, but ethno-religious distinction in Northern Ireland. This article looks at how individuals reconstruct their way being Protestant Ireland and the context social change. It shows renegotiating ways Protestant, attempting sometimes successfully change its socio-cultural salience, blurring ethnic boundaries, distinguishing religious ethno-national narratives, drawing universalistic norms from...
Abstract STUDY QUESTION Is large for gestational age (LGA) observed in babies born after frozen embryo transfer (FET) associated with either the freezing technique or endometrial preparation protocol? SUMMARY ANSWER Artificial cycles are a higher risk of LGA, no difference rate between two techniques (vitrification versus slow freezing) stage (cleaved blastocyst). WHAT IS KNOWN ALREADY Several studies have compared neonatal outcomes fresh (ET) and FET shown that is improved outcomes,...