A5101611180- Blood properties and coagulation
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Cancer-related gene regulation
- Blood Coagulation and Thrombosis Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Immunotherapy and Biomarkers
- Vasculitis and related conditions
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Renal and Vascular Pathologies
- Caveolin-1 and cellular processes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antiplatelet Therapy and Cardiovascular Diseases
- Renal Transplantation Outcomes and Treatments
- Lipid metabolism and disorders
- Magnesium in Health and Disease
- Organ Donation and Transplantation
- Parathyroid Disorders and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Atrial Fibrillation Management and Outcomes
- Ferroptosis and cancer prognosis
- Hemoglobinopathies and Related Disorders
Zhongda Hospital Southeast University
2025
Ruijin Hospital
2015-2020
Shanghai Jiao Tong University
2013-2020
Renji Hospital
2017-2019
Shanghai Institute of Hematology
2015-2017
Zhejiang University
2013
China Medical University
2010
Background Platelet-neutrophil aggregates (PNAs) are fundamental mechanisms linking hemostasis and inflammatory processes. Elevated level of PNAs have been reported in diseases coronary artery diseases. However, studies on the correlation between formation deep venous thrombosis (DVT) not available. Methods A total 92 participants were involved this study, including 32 cases with DVT 60 without DVT. Blood samples coagulated by K2-EDTA or sodium citrate prepared for blood cell count smears....
Background: X-linked hypophosphatemia (XLH) is the most common form of heritable rickets characterized by dominant inheritance, renal phosphate wasting, hypophosphatemia, and defective bone mineralization. Inactivating mutations PHEX gene located at Xp22.1 have been linked with this disease. Ethnic distribution such seems widespread but only a few in Chinese population reported to date. Materials Methods: We report on large Han family affected XLH rickets, which included 13 patients from...
Introduction Inhibitor development is a severe complication of factor IX substitution treatment for haemophilia B (HB). Current research examined the association between inhibitor and F9 genotypes polymorphisms in immune response genes Chinese HB patients. Materials Methods 11 inhibitor‐positive patients 41 inhibitor‐negative were enrolled. Direct sequencing, copy number variation ( CNV ) detection fragment length analysis applied to identify 15 genes. Results 7 developed high titer...
A novel heterozygous variant, FGA c.169_180+2 del (designated fibrinogen Shanghai), was identified in a patient with dysfibrinogenemia antiphospholipid antibody syndrome (APS) and recurrent venous thrombosis, his asymptomatic father. We aimed to reveal the functional implication of structural change caused by this variant.Transcription analysis performed minigene transfection assay evaluate impact nucleosides deletion on mRNA editing. The isolated from propositus' plasma used characterise...
Abstract Objective We aimed to establish the reference range of thromboelastograph (TEG) maximum amplitude (MA) in patients taking antiplatelet drugs. Methods Between August 2015 and July 2018, a total 4614 administrating with drugs (clopidogrel aspirin) were retrospectively analyzed this study. For MA A parameter, we used 10th 90th percentiles range. The Spearman correlation was for analysis among inhibition rate adenosine diphosphate (ADP%) ADP , arachidonic acid (AA%) AA . Then, through...
Objective: Integrin β3 is implicated in numerous biological processes such as its relevance to blood triglyceride, yet whether deficiency affects this metabolic process remains unknown. Approach and Results: We showed that the Chinese patients with β3-deficient Glanzmann thrombasthenia had a 2-fold higher serum triglyceride level together lower LPL (lipoprotein lipase) than those an αIIb or healthy subjects. The knockout mice recapitulated these phenotypic features. elevated plasma was due...
Hereditary protein S (PS) deficiency is one of the natural anticoagulant deficiencies causing thrombophilia. We herein described a young male with recurrent deep venous thrombosis, who was diagnosed as type I PS compound heterozygous mutations PROS1 gene. aimed to analyse relationship between genotype and phenotype detection investigate pathological mechanisms deficiency.Genetic analysis gene carried out by direct sequencing. Thrombin generation potential inhibition function thrombin plasma...
Aims The frequency of X chromosome pericentric inversion is much less than that autosome chromosome. We hereby characterise a associated with severe factor VIII (FVIII) deficiency in sporadic haemophilia A (HA) pedigree. Methods PCR primer walking and genome strategies were adopted to identify the exact breakpoints inversion. Copy number variations (CNVs) F8 whole chromosomes detected by AccuCopy Affymetrix CytoScan High Definition (HD) assays, respectively. karyotype analysis was performed...
To investigate the function of abnormal fibrinogen in two inherited dysfibrinogenemia pedigrees.Routine coagulation tests were conducted probands and related family members. The antigen activity levels detected by immunoturbidimetry assay clauss assay, respectively. All exons exon-intron boundaries three genes antithrombin gene（AT3）were analyzed PCR amplification direct sequencing. Routine thrombelastography (TEG) test functional TEG both used to make a comprehensive evaluation status level...