A5043598587- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cardiovascular Function and Risk Factors
- Histiocytic Disorders and Treatments
- Esophageal Cancer Research and Treatment
- Advanced X-ray and CT Imaging
- Lung Cancer Research Studies
- Cervical Cancer and HPV Research
- Metabolism and Genetic Disorders
- Medical Image Segmentation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Long-Term Effects of COVID-19
- Cardiovascular Disease and Adiposity
- Medical Imaging Techniques and Applications
- Genital Health and Disease
- Neuropeptides and Animal Physiology
- Facial Trauma and Fracture Management
- Cardiac, Anesthesia and Surgical Outcomes
- Voice and Speech Disorders
- Cancer Immunotherapy and Biomarkers
Imperial College Healthcare NHS Trust
2015-2023
Imperial College London
2011-2022
Cardiff University
2020
Royal Gwent Hospital
2019
The University of Kansas Health System
2019
Cambridge University Hospitals NHS Foundation Trust
2014-2018
Wrexham Maelor Hospital
2018
Addenbrooke's Hospital
2015-2016
Glan Clwyd Hospital
2016
Great Ormond Street Hospital
2016
Opioid neurotransmission has a key role in mediating reward-related behaviours. receptor (OR) antagonists, such as naltrexone (NTX), can attenuate the behaviour-reinforcing effects of primary (food) and secondary rewards. GSK1521498 is novel OR ligand, which behaves an inverse agonist at μ-OR sub-type. In sample healthy volunteers, we used [11C]-carfentanil positron emission tomography to measure occupancy functional magnetic resonance imaging (fMRI) activation brain reward centres by...
To examine the level of awareness link between human papillomavirus (HPV) and oropharyngeal cancer (OPC) epidemiological trends in HPV-related OPC among general practitioners (GPs) UK.Cross-sectional survey.384 GPs from England, Scotland, Wales Northern Ireland.The survey was administered at GP training courses via email to lists course attendees.Proportion respondents aware HPV OPC; respondents' self-rated knowledge proportion participants HPV-associated OPC.384 questionnaires were...
Pre-operative imaging is often used to predict the extent of a cholesteatoma and anatomical variation plan for surgery. This study aimed measure predictive accuracy computed tomography findings.A retrospective cohort was conducted all patients in district general hospital undergoing mastoid surgery within consecutive 12-month period, whom had been performed prior operative intervention. The measured key findings pre-operative compared them intra-operative total 106 were included. sensitivity...
Abstract Background and purpose Artificial intelligence (AI) has the potential to greatly improve efficiency reproducibility of quantification in echocardiography, but gain widespread use it must both meet expert standards excellence have a transparent methodology. We developed an online platform enable multiple collaborators annotate medical images for training validating neural networks. Methods Using our collaborative 9 echocardiographers labelled 2056 that comprised dataset. They four...
Abstract Background Left ventricular longitudinal strain has been reported to deliver reproducibility, sensitivity and prognostic value over above ejection fraction. However, it currently relies on uninspectable proprietary algorithms suffers from a lack of widespread clinical use. Uptake may be improved by increasing user trust through greater transparency. Purpose We therefore developed machine-learning based method, trained, validated with accredited experts our AI Echocardiography...
Abstract Funding Acknowledgements Type of funding sources: None. Introduction The assessment aortic valve pathology using magnetic resonance imaging (MRI) typically relies on blood velocity estimates acquired phase contrast (PC) MRI. However, abnormalities in flow through the often manifest by dephasing signal gated balanced steady-state free precession (bSSFP) scans (cine MRI) [1]. This suggests cine MRI may be used to identify patients with who would benefit from additional detailed PC-MRI...
<h3>Background</h3> Some patients are found to have myocardial scarring after infection with coronavirus-2019 disease (COVID-19) as evidenced by the presence of late gadolinium enhancement on cardiac MRI (CMR). In many types heart disease, (even without symptoms) is associated a poorer prognosis. However, it not known whether scar COVID-19 outcome. <h3>Purpose</h3> This study explores association between (LGE) in recovered and longer-term clinical outcomes. <h3>Methods</h3> this...
<h3>Introduction</h3> Pulmonary vein isolation (PVI) is a commonly used element in treatment of atrial fibrillation (AF) but has never been tested an intentionally placebo (sham) controlled trial. Nevertheless there have several randomized trials (RCTs) which both arms receive ablation procedure the only difference between inclusion or omission PVI. As long as doctor and patient reason to believe that procedures are effective, such RCTs could be effective proxy for trials. <h3>Methods</h3>...
Abstract Background Improving the efficiency of CMR by acquiring fewer, and more targeted sequences, would improve diagnostic yield reduce patient recalls. An AI-assisted clinical decision support system (CDSS) could deliver this using adaptive scanning protocols which replicate expertise highly trained clinicians. Normal aortic valve anatomy on three-chamber (3CH) cine is a guide to rationalising subsequent therefore suitable base case for developing an AI-CDSS CMR. Purpose We propose...
Abstract Background Despite the knowledge that suboptimal adherence to medications may have an impact on of treatment interventions, assessment and reporting medication in cardiovascular randomised controlled trials has not been well studied. In this review we sought study differences (RCTs) comparing interventional procedures medical therapy alone four major conditions: coronary disease (CAD), atrial fibrillation (AF), heart failure (HF) hypertension (HTN). Methods Comprehensive searches...