A5100434357- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Skin and Cellular Biology Research
- Immune Cell Function and Interaction
- RNA regulation and disease
- Hereditary Neurological Disorders
National Cancer Center
2020-2023
Yonsei University
2023
Institute of Clinical Research
2021
Importance Immunoglobulin G autoantibodies for aquaporin 4 (AQP4-IgG) serve as diagnostic biomarkers neuromyelitis optica spectrum disorder (NMOSD), and the most sensitive specific laboratory tests their detection are cell-based assays (CBAs). Nevertheless, limited availability of special instruments limits widespread use CBAs in routine laboratories. Objective To validate an enzyme immunodot assay simple rapid AQP4-IgG. Design, Setting, Participants This multicenter case-control study,...
Information on subclinical astrocyte damage can provide further insight into neuromyelitis optica spectrum disorder (NMOSD) pathophysiology and disease-monitoring strategies. To investigate whether neuroaxonal occurs during interattack periods in individuals with NMOSD through longitudinal measurement of serum glial fibrillary acidic protein (sGFAP) neurofilament light chain (sNfL) at multiple time points.
To evaluate the occurrence of attack-independent neuroaxonal and astrocytic damage in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), serum neurofilament light chain (sNfL) glial fibrillary acidic protein (sGFAP) levels were longitudinally measured 102 sera using a single-molecule array assay. Sera from 15 adults with relapsing MOGAD available longitudinal samples for median 24-month follow-up 26 age-/sex-matched healthy controls analyzed. sNfL significantly elevated...
We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using live cell–based assay for MOG AQP4 antibodies. Of 586 IDDs CNS, 36 (6.1%) 185 (31.6%) tested positive antibodies, respectively. No participant showed double positivity. Seroprevalence was about five times...
Defective regulatory B cells that contribute to autoimmunity are recovered by cell depletion therapy in patients with NMOSD.