Increased numbers of bone marrow-derived progenitor cells, known as fibrocytes, populate the peripheral circulation, orbit, and thyroid patients with Graves' disease (GD). These cells have been implicated in development thyroid-associated ophthalmopathy. They can differentiate into myofibroblasts or adipocytes, produce inflammatory cytokines, remodel tissue. This study sought to determine whether thyrotropin (TSH) CD40 ligand (CD40L), pathogenesis GD, induce interleukin-12 (IL-12) human...

The aims of this study were to investigate 21 cases transcranial orbitotomy for cranio-orbital tumors and evaluate the clinical value surgical approach.A retrospective was done on patients with tumors. According tumors' location, shape, boundary, invasion images, coronal scalp flap approach, subfrontal or pterion approach performed.The route in 7 (including 3 combined lateral orbitotomy), 6 cases, 8 1 case evisceration orbit). Tumors en bloc resection 4 block curettage 13 incomplete cases....

Objective. To observe the clinical efficacy of periocular injection triamcinolone acetonide (TA) and subpalpebral botulinum toxin type A (BTXA) for treatment thyroid-associated ophthalmopathy (TAO) with mild unilateral upper eyelid retraction. Method. This was a prospective randomized controlled study. total 68 cases stable retraction were collected at Hankou Aier Eye Hospital from Jan. 2015 to Dec. 2018 randomly divided into two groups. Group contained 33 patients who administered TA by...

Objective. To explore the clinical manifestations, imaging characteristics, and pathological characteristics of Castleman’s disease lacrimal gland, enhance knowledge disease, improve level its diagnosis treatment. Methods. In retrospective study, data 5 patients diagnosed with gland in Tianjin Medical University Eye Hospital from 2014 to 2018 were analyzed, relevant literature was reviewed. Results. All confirmed by examination. Clinical manifestations characterized mass occupying lesions...

We aimed to evaluate the genetic variation of poly (ADP-ribose) polymerase-1 (PARP-1) as risk factor in development Graves' disease (GD) and ophthalmopathy (GO) among Chinese individuals. Patients with confirmed diagnosis GD or healthy individuals no clinical symptoms hyperthyroiditis were enrolled at Department Ophthalmology, Tianjin First Center Hospital, China. Genetic polymorphism was studied plasma DNA samples subjects by polymerase chain reaction restriction fragment length confirm our...

Objective To study postoperative tear changes after penetrating keratoplasty.Methods Penetrating keratoplasty was done in 25 cases (25 eyes),with the healthy eye served as a control group.Dry questionnaire,tear break-up time (BUT),basal secretion test (SIt),corneal fluorescein staining (FL) examination were observed 3 days before surgery,and 1 week,1 month,3 months and 6 surgery.Comparison between two groups.Results At each point operation,dry symptom score,FL score significantly higher than...

Objective: To measure the ocular volume and extraocular muscles of healthy people using high-resolution magnetic resonance imaging (HR-MRI) technology, to provide parameters support for eye research, teaching diagnosis. Methods: The study collected 100 cases normal subjects (200 eyes) from November 2012 December 2013, including 50 males females, accepted line HR-orbital MRI, image processing software was applied morphology statistical analysis. muscles, muscle belly level horizontal diameter...

Objective To explore the recurrence and poor prognosis mechanism from perspective multi-drug resistance (MDR) by detecting expression of P-gp,GST-π LRP in orbital lymphoma.Methods Fifty lymphoma tissue which were diagnosed pathology after surgery collected Tianjin eye hospital first centre hospital.Among them,46 cases observation group.Meanwhile,17 reactive lymphoid hyperplasia tissues as contrast group.Orbital microarray immunohistochemical staining was used to detect hyperplasia.Results...

Objective To analyze the change of tear film after phacoemulsification in patient with renal transplantation and discuss problem dry eye.Methods A non-randomized cases-controlled study was designed.26 cataract patients (the experimental group) (34 eyes) matched 33 (40 age-related cataract(control were included this study.Before different time IOL implantation respectively performed on all patients,dry eye-related symptom surveyed scored by questionnaire,and break-up (BUT),Schirmer I test...

Objective To present some reference for accurate diagnosis and treatment of orbital space-occupying lesions in clinic,and to analyze the pathological classification evaluate frequencies various types lesions.Methods In this retrospective case series,the medical records 165 patients referred Tianjin first center hospital between November 2009 2012 were reviewed.Results Benign tumors found 98 eyes (59.39％),the leading 3 cavernous hemangioma,21 (21.43％); inflammatory pseudotumor,19 (19.39％);...

Objective To investigate clinical and imaging features in children orbital tumors.Methods Collected 44 tumors from January 2010 to September 2012,the types,clinical manifestation results were statistical analyzed retrospectively.Results Among cases of tumors,40 benign which included 21 vasculogenic tumors,9 cystic tumors,6 histiocytosis 4 bonic tumors; malignant 3 myogenic 1 secondary tumor.Clear boundary,even or uneven density with bone absorption CT tumors,low signal T1WI high T2WI seen...

Objective To investigate the various surgical techniques and their effects for correcting different types of blepharoptosis.Methods From June 2002 to October 2007,460 eyes 379 eases patients with congenital blepharoptosis were received treatment.The severe 300 cases(381 eyes),the moderate 47 cases(47 eyes)and mild 32 cases(32 eyes).The included fascia lata sling 196 cases(246 eyes),frontalis muscle flap suspension 104 cases(135 eyes),superior levator shortening superior aponeurosis folding...

Objective To study the clinical histopathological character and imaging feature of ocu-lar adnexal mucosa-associated lymphoid tissue (MALT) lymphoma. Methods A retrospective MALT lymphoma was performed to investigate feature, data. Results The most common kind orbit 68% (26/38), minority lacrimal gland 15.8% (6/38). It could also occur in conjunctiva, single eye, but on both eyes. The main manifestations were eyelid swelling, proptosis, conjunctival hyperemia, diplopia vision...