A5027403151- Cutaneous lymphoproliferative disorders research
- Public Health Policies and Education
- Diversity and Career in Medicine
- Prostate Cancer Diagnosis and Treatment
- Fungal Infections and Studies
- Drug-Induced Adverse Reactions
- T-cell and B-cell Immunology
- Medicine and Dermatology Studies History
- Health Literacy and Information Accessibility
- Genital Health and Disease
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Cancer Immunotherapy and Biomarkers
- Autoimmune Bullous Skin Diseases
- Eosinophilic Disorders and Syndromes
- Colorectal Cancer Treatments and Studies
- Chemotherapy-related skin toxicity
- Psoriasis: Treatment and Pathogenesis
- Infection Control and Ventilation
- Social Media in Health Education
- Cancer survivorship and care
- Innovations in Medical Education
- Lymphoma Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Burn Injury Management and Outcomes
Boston University
2025
Harvard University
2019-2023
Brigham and Women's Hospital
2021-2023
South China Agricultural University
2022
Massachusetts General Hospital
2021
Dana-Farber Brigham Cancer Center
2021
Lemuel Shattuck Hospital
2019
Massachusetts Eye and Ear Infirmary
2019
Yale University
2016
Cedars-Sinai Smidt Heart Institute
2014
Evidence suggests that distinct splenic dendritic cell (DC) subsets activate either CD4+ or CD8+ T cells in vivo. This bias has been partially ascribed to differential antigen presentation; however, all DC can both lineages vitro. Therefore, we tested whether the organization of and spleen dictated this preference. We discovered segregated within zones prior immunization. After intravenous immunization, two major conventional populations, distinguished by 33D1 XCR1 staining, migrated into...
Psoralen plus UVA (PUVA) is an effective therapy for mycosis fungoides (MF), the skin-limited variant of cutaneous T cell lymphoma (CTCL). In low-burden patients, PUVA reduced or eradicated malignant cells and induced clonal expansion CD8+ associated with depletion. High-burden patients appeared to clinically improve but large numbers persisted in skin. Clinical improvement was linked turnover benign clones not reduction. Benign were Th2-recruiting chemokine CCL18 before Th1-recruiting...
<h3>Importance</h3> Up to 90% of patients treated with an epidermal growth factor receptor inhibitor (EGFRi) experience cutaneous toxic effects that are negatively associated quality life and lead treatment interruptions. The Skin Toxicity Evaluation Protocol With Panitumumab trial found reduced incidence skin toxicity impairment preemptive use doxycycline hyclate, topical corticosteroids, moisturizers, sunscreen, demonstrating the benefit prophylactic for toxicity. <h3>Objective</h3> To...
Abstract Background In response to supply shortages caused by the COVID-19 pandemic, N95 filtering facepiece respirators (FFRs or “masks”), which are typically single-use devices in healthcare settings, routinely being used for prolonged periods and some cases decontaminated under “reuse” “extended use” policies. However, reusability of masks is limited degradation fit. Possible substitutes, such as KN95 meeting Chinese standards, frequently fail fit testing even when new. The purpose this...
Proper postharvest storage preserves horticultural products, including tea, until they can be processed. However, few studies have focused on the physiology of ripening and senescence during storage, which affects flavor quality tea. In this study, physiological biochemical indexes leaves tea cultivar 'Yinghong 9' preserved at a low temperature high relative humidity (15-18 °C 85-95%, PTL) were compared to those stored ambient conditions (24 ± 2 65% 5%, UTL). Water content, chromatism,...
Synaptic loss is critical in Alzheimer's disease (AD), but the dynamics of synapse turnover are poorly defined. We imaged dendritic spines transgenic APPswe/PSen1∆E9 (APP/PS1) cerebral cortex. Dendritic spine increased far from plaque aged APP/PS1 mice, and young mice prior to formation. Dysregulation occurs presence soluble Aβ oligomer requires cellular prion protein (PrPC). lack responsiveness sensory stimulation. Critically, enhanced coupled with persistent starting early continuing age....
A significant proportion of cancer survivors endorse ongoing health information needs and may use the internet to access information. We assessed patterns predictors general health-specific among survivors.Using data from National Health Interview Survey (NHIS), which was administered in 2013 through 2018, for adults reporting a diagnosis, sample weight-adjusted estimates defined prevalence multivariable logistic regressions adjusted odds ratios (aORs) use, adjusting relevant...
<b><i>Background/Aims:</i></b> The importance of adjuvant radiotherapy in patients with close margin resections for mucoepidermoid carcinoma the parotid gland remains unclear. <b><i>Methods:</i></b> Patients who underwent parotidectomy or without at a single academic tertiary care center from 2000 to 2014 were identified. Included had negative but (≤2 mm) surgical margins other high-risk histopathological factors including advanced T-stage,...
ABSTRACT Background In response to supply shortages during the COVID-19 pandemic, N95 filtering facepiece respirators (FFRs or “masks”), which are typically single-use devices in healthcare settings, routinely being used for prolonged periods and some cases decontaminated under “reuse” “extended use” policies. However, reusability of masks is often limited by degradation breakage elastic head bands issues with mask fit after repeated use. The purpose this study was develop a frame masks,...
Yu, Zizi BA; Dee, Edward Christopher BS; Nambudiri, Vinod E. MD, MBA; Ogbechie-Godec, Oluwatobi A. Jakus, Jeannette Siegel, Daniel M. MD Author Information
BACKGROUND Recently, there have been calls to improve diversity among the dermatology workforce, with emphasis placed on resident selection process and trainee pipeline. However, is limited data perspectives of applicants, especially UIM trainees, support that they need want successfully apply in dermatology. METHODS To assess perspectives, we disseminated a survey medical students, interns (matched into dermatology), residents asking how residency programs can best trainees through...
Idiopathic hypereosinophilic syndrome (IHES) is a rare disorder defined by (1) eosinophilia (eosinophil count > 1.5 × 109/L) on 2 examinations 1 month apart, (2) organ damage and/or dysfunction attributable to tissue hypereosinophilia, and (3) lack of clear alternate cause.1 Eosinophil-related consists eosinophilic infiltrates associated with fibrosis, thrombosis, cutaneous erythema or ulceration. It occurs predominantly in men ages 20 50 years.2 Systemic manifestations include...
Mucormycosis is a rare and aggressive fungal infection, most often caused by species of the Mucor, Rhizomucor, Rhizopus, Absidia, Cunninghamella genera. The condition commonly affects patients with uncontrolled diabetes, HIV/AIDS, malignancy, those receiving long-term immunosuppressive therapy. We report case 39-year-old male biopsy-proven cutaneous mucormycosis left axilla 4 months after an orthotopic heart transplant for congenital tricuspid atresia.
The physician voice is crucial to shaping health policy and public guidelines, particularly during COVID-19. However, there are gaps in advocacy education within graduate medical education. This study sought characterise the impact of a virtual COVID-19 focused day among trainees Massachusetts.The half-day event featured speakers drawn from government relations experts, advocates, state federal legislators as well breakout discussions attendees. A 25-question Redcap survey list...
BACKGROUND Dermatology is among the least racially/ethnically diverse medical specialties in US Interest Groups (DIGs). DIGs may play a critical role addressing these disparities by facilitating early exposure and mentorship, both associated with higher rates of students pursuing specific fields. OBJECTIVE This study sought to characterize activities, goals, challenges schools nationwide. METHODS A 15-question survey was distributed electronically 92 DIG leaders enrolled four-year accredited...
Leukocytoclastic vasculitis (LCV) is a small-vessel that most commonly affects the postcapillary venules in skin. It classically presents with purpuric macules progress to palpable purpura on bilateral shins 7-10 days after an inciting medication or infection, setting of connective tissue disease, malignancy, inflammatory bowel disease. Up 50% cases have no identifiable cause. Lesions buttocks, abdomen, upper extremities, and face are uncommon, as bullae ulcers. We present rare case bullous...
ABSTRACT We describe a 14‐year‐old boy with Wilson disease (WD) who first developed pseudo‐pseudoxanthoma elasticum (PPXE) after 4.5 years of treatment D‐penicillamine. Although previously reported cases have occurred in adults following at least decade high‐dose D‐penicillamine use, this case demonstrates that D‐penicillamine‐induced PPXE can present children shorter courses. Upon diagnosis, the patient was switched from to trientine, adequate cupriuresis and stabilization skin lesion....