A5087112362- Reconstructive Surgery and Microvascular Techniques
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Ear and Head Tumors
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Polyomavirus and related diseases
- Tracheal and airway disorders
- Reconstructive Facial Surgery Techniques
- Trauma Management and Diagnosis
- Head and Neck Surgical Oncology
- Cancer and Skin Lesions
- Infectious Diseases and Mycology
- Voice and Speech Disorders
- CAR-T cell therapy research
- Antenna Design and Analysis
- Surgical site infection prevention
- Full-Duplex Wireless Communications
- Oral and Maxillofacial Pathology
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Dysphagia Assessment and Management
- Melanoma and MAPK Pathways
- Surgical Sutures and Adhesives
- Lymphoma Diagnosis and Treatment
Massachusetts Eye and Ear Infirmary
2016-2025
Harvard University
2016-2025
Massachusetts General Hospital
2012-2022
Harvard University Press
2009
Abstract Purpose: HPV-associated head and neck squamous cell carcinoma (HPV+HNSCC) is the most common malignancy in United States continues to increase incidence. Current diagnostic approaches for HPV+HNSCC rely on tissue biopsy followed by histomorphologic assessment detection of HPV indirectly p16 IHC. Such are invasive have variable sensitivity. Experimental Design: We conducted a prospective observational study 140 subjects (70 cases 70 controls) test hypothesis that noninvasive approach...
6010 Background: Prediction of minimal residual disease (MRD) following surgery, and thus the need for adjuvant therapy, is currently based on clinicopathologic risk factors which have poor individual prognostic capacity. We previously reported that MRD detection by ctHPVDNA droplet digital (dd)PCR as early post-operative day (POD) 1 predictive recurrence in stage I-II HPV+HNSCC patients. Here, we applied a significantly more sensitive custom whole genome hybrid-capture-based next generation...
Determine the time of onset and microbiology surgical site infections (SSIs) following head neck free flap reconstructive surgeries.Retrospective cohort study.All 504 cases (484 patients) performed April 1, 2009 to September 30, 2013 were reviewed; SSIs occurring ≤30 days postoperatively evaluated. Admission screening for methicillin-resistant Staphylococcus aureus (MRSA) colonization was on all patients.Flap-recipient (flap SSIs) occurred in 67 (13.3%), one-third week 1 postoperatively, 2,...
Report on the successful use of supraclavicular flap for reconstruction following total laryngectomy and highlight utility versatility after laryngectomy.Retrospective review a single institution experience.A database was reviewed to identify patients undergoing reconstruction. The data were collected: indication reconstruction, viability, size, site complication, donor complication.Forty-six flaps identified in from July 2011 September 2013. Fifteen these used laryngectomy. Ten patch graft...
arotid and lateral skull base (LSB) surgery defects create a different set of reconstructive challenges compared with typical aerodigestive tract head neck cancer reconstruction.Typical goals for reconstruction focus on separating the from skin external surface body restoring functions swallowing voice production modulation.Because glandular function cannot be replaced, parotid defect is primarily focused facial contour.In case total parotidectomy LSB surgery, also provides additional...
Objective To characterize patterns of utilization and outcomes following transfusion in head neck patients undergoing free flap reconstruction. Study Design Case series with chart review. Setting Tertiary academic medical center. Subjects Methods Two hundred eighty‐two reconstruction from 2011 to 2013. Outcome parameters included post‐transfusion hematocrit increase, length stay (LOS), survival, perioperative complications. Results Of all patients, 48.9% received blood transfusions. Average...
Analysis of The Cancer Genome Atlas and other published data head neck squamous cell carcinoma (HNSCC) reveals somatic alterations the Hippo-YAP pathway in approximately 50% HNSCC. Better strategies to target YAP1 transcriptional complex are sought. Here, we show that FAT1, an upstream inhibitor YAP1, is mutated either by missense or truncating mutation 29% Comprehensive proteomic drug-screening studies across pan-cancer models confirm FAT1-mutant HNSCC exhibits selective higher sensitivity...
Merkel cell carcinoma (MCC) is a very rare but highly aggressive cutaneous neuroendocrine and associated with chronic exposure to ultraviolet light the polyoma virus. The incidence rate of MCC increasing high rates recurrence mortality. Immune checkpoint inhibitors (ICIs) offer durable responses significant clinical benefit 2 agents-avelumab (anti-PD-L1) pembrolizumab (anti-PD-1)-currently approved by U.S. Food Drug Administration for treatment advanced MCC. Despite advances in systemic...
Purpose: To review the treatment response of advanced conjunctival squamous cell carcinoma (SCC) to systemic immune checkpoint inhibitor (ICI) therapy at a single institution. Methods: A retrospective patients treated institution from 2015 2024 was conducted identify those with SCC who had been ICI therapy. Advanced disease included orbital invasion tumors, unresectable disease, or metastatic disease. Computed tomography imaging and tumor mutational burden data were evaluated for all...
Outcomes of the supraclavicular artery island flap (SCAIF) have not been extensively studied in comparison with free tissue transfer (FTT) flaps for head and neck reconstruction. We hypothesize that pedicled SCAIF has decreased operating room time, length stay, time to wound healing recipient site, complications, hospital charges as compared FTT.Case series chart review.Tertiary care teaching hospital.Medical records were reviewed patients who underwent (n = 45) or FTT 28) reconstruction...
The supraclavicular artery island flap (SCAIF) is a pedicled fasciocutaneous used for head and neck reconstruction. In recent years, its use has significantly increased as result of several advantageous characteristics, including pliability, an excellent color texture match, ability to reconstruct variety skin aerodigestive tract defects, short harvest times. Clinical experience suggests that donor site complications are relatively infrequent typically self-limiting, there have been no...
The precise indications and oncologic effects of adjuvant radiotherapy in acinic cell carcinoma the parotid gland are not well known, particularly patients with negative, but close (≤1 mm), margins without other high-risk histopathologic factors.To evaluate outcomes results therapy for those (≤1-mm) margins.In a retrospective case series medical record review at single academic tertiary referral center, treated surgically from January 2000 to December 2014 were identified an institutional...
Compliance with Surgical Care Improvement Project (SCIP) parameters regarding antibiotic prophylaxis may affect surgical site infection rates. The purpose of this study was for us to report SCIP compliance, rates, and risk factors in a large series head neck free flap surgeries.A retrospective review 480 cases performed. infections occurring within 30 days postoperatively were noted.Surgical occurred 13.3% cases. Prophylaxis given 99.8% cases; ampicillin-sulbactam (83%) clindamycin (9%) most...
IMPORTANCE This study demonstrates the versatility of supraclavicular artery (SCA) flap in head and neck reconstruction offers technical highlights to improve efficiency harvest. OBJECTIVES To report our series diverse reconstructions utilizing SCA highlight several aspects harvest that make procedure more safe, reliable, efficient. DESIGN, SETTING, AND PARTICIPANTS A retrospective review was conducted from July 2011 December 2012 on all patients who had undergone a defect at tertiary...
To evaluate surgical site infections (SSI) after pedicled reconstruction in head and neck surgery.Records of patients with flap reconstructions between 2009 2014 at Massachusetts Eye Ear were reviewed. Onset SSI or fistula ≤30 days postoperatively was noted. A free cohort reviewed for comparison.Two hundred eight performed cancer (83%), osteoradionecrosis (7%), other reasons (10%). Most (72%) cases clean-contaminated American Society Anesthesiologists classification 3 higher (73%); 63% had...
Objectives/Hypothesis To investigate the impact of specific treatment‐related variables on functional and quality life outcomes in oral cavity cancer (OCC) patients. Study Design Retrospective Cohort. Methods Patients with primary OCC at least 6 months after resection adjuvant therapy were included. completed surveys including Speech Handicap Index (SHI), M.D. Anderson Dysphagia Inventory (MDADI), Functional Assessment Cancer Therapy‐Head Neck (FACT‐HN). Performance Status Scale (PSS) tongue...
<h3>Objectives</h3> To assess the incidence of symptomatic tubal tonsil hypertrophy (TTH) after adenoidectomy and to attempt differentiate clinicoradiographic presentation TTH from that recurrent or residual adenoid. <h3>Design</h3> Retrospective case series review. <h3>Setting</h3> Pediatric otolaryngology practice in a tertiary care hospital. <h3>Patients</h3> The charts all patients scheduled undergo revision nasopharyngeal examination under anesthesia over 5-year period 1 pediatric...