Laura van Gulik
A5013342709- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Pain Management and Opioid Use
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and Mental Health
- Machine Learning in Healthcare
- Anesthesia and Pain Management
- COVID-19 diagnosis using AI
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 and COVID-19 Research
- Pediatric Pain Management Techniques
- Viral Infections and Outbreaks Research
- Veterinary Pharmacology and Anesthesia
- Medical Coding and Health Information
- Ectopic Pregnancy Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Family and Patient Care in Intensive Care Units
- Anesthesia and Neurotoxicity Research
- Diabetic Foot Ulcer Assessment and Management
- Gestational Trophoblastic Disease Studies
University of Oxford
2021-2024
Utrecht University
2023-2024
University Medical Center Utrecht
2023-2024
Heidelberg University
2021-2024
University Hospital Heidelberg
2021-2024
Meander Medisch Centrum
2022-2024
Maastricht University
2024
Infectious Diseases Data Observatory
2023
International Severe Acute Respiratory and Emerging Infection Consortium
2023
Universitat Internacional de Catalunya
2020
Pain in critically ill patients the intensive care unit (ICU) is common. However, pain assessment often complicated because these are unable to communicate effectively. Therefore, we designed a study (a) determine inter-rater reliability of Numerical Rating Scale (NRS) and Behavioral (BPS), (b) compare scores different observers patient, (c) NRS, BPS, Visual Analog (VAS) for measuring ICU. We performed prospective observational 113 non-paralyzed patients. The attending nurses, two...
This study examines the influence of patient demographics and peri- postoperative (<7 days) characteristics on incidence chronic thoracic pain 1 year after cardiac surgery. The impact daily life is also documented.A prospective cohort 146 patients admitted to intensive care unit surgery via sternotomy was carried out. Pain scores (numeric rating scale 0-10) were recorded during first 7 days. One later, a questionnaire used evaluate in 2 preceding weeks >0) associated with primary surgery.One...
Abstract Background To assess trends in the quality of care for COVID-19 patients at ICU over course time Netherlands. Methods Data from National Intensive Care Evaluation (NICE)-registry all admitted to an Netherlands were used. Patient characteristics and indicators during first two upsurges (N = 4215: October 5, 2020–January 31, 2021) final upsurge second wave, called ‘third wave’ 4602: February 1, 2021–June 30, compared with those wave 2733, February–May 24, 2020). Results During third...
Abstract Background Previously, we reported a decreased mortality rate among patients with COVID-19 who were admitted at the ICU during final upsurge of second wave (February–June 2021) in Netherlands. We examined whether this decrease persisted third and phases decreasing incidence thereafter brought up to date information on patient characteristics. Methods Data from National Intensive Care Evaluation (NICE)-registry all an Netherlands used. Patient characteristics rates in-hospital (the...
The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application experimental stimuli. relevance these findings in morphine-treated postoperative cardiac patients undergoing painful healthcare procedures is unknown; therefore, the aim this study was to investigate whether COMT increases an unavoidable routine procedure after surgery.One hundred and seventeen intensive care unit were genotyped for polymorphism. All treated with...
Although clinical guidelines recommend systematic evaluation of pain in ICU patients, we know little about the effects from such evaluation. This study aims to quantify effect a management programme ICU.In this prospective two-phase study, levels scored by patients after cardiac surgery through sternotomy were compared before and implementation programme. The consisted three-fold strategy; all staff was trained assessing providing adequate analgesia, new patient data system obliged nurses...
In Brief BACKGROUND: Although morphine is used frequently to treat pain in the intensive care unit, its pharmacokinetics has not been adequately quantified critically ill patients. We evaluated glucuronidation and elimination clearance of patients compared with healthy volunteers based on morphine-3-glucuronide (M3G) concentrations. METHODS: A population pharmacokinetic model covariate analysis was developed nonlinear mixed-effects modeling software (NONMEM 7.3). The included 3012 M3G...
As pain in the intensive care unit (ICU) is still common despite important progress management, we studied efficacy of an intravenous bolus morphine 2.5 vs 7.5 mg for procedural relief patients after cardiothoracic surgery ICU. In a prospective double-blind randomised study, 117 ICU were included. All treated according titration protocol at rest, consisting continuous infusions and paracetamol, applied during entire stay. On first postoperative day, to (n=59) or (n=58) 30 minutes before...
Describe the differences in characteristics and outcomes between COVID-19 other viral pneumonia patients admitted to Dutch ICUs.Data from National-Intensive-Care-Evaluation-registry of February 15th January 1th 2021 1st 2017 2020 were used. Patients' characteristics, unadjusted, adjusted in-hospital mortality compared.6343 2256 79 ICUs included. The included more male (71.3 vs 49.8%), had a higher Body-Mass-Index (28.1 25.5), less comorbidities (42.2 72.7%), prolonged hospital length stay...
Objective prognostic information is essential for good clinical decision making. In case of unknown diseases, scarcity evidence and limited tacit knowledge prevent obtaining this information. Prediction models can be useful, but need to not only evaluated on how well they predict, also stable these are under fast changing circumstances with respect development the disease corresponding response. This study aims provide interpretable actionable insights, particularly clinicians. We developed...
A volunteer study suggested that taking paracetamol 4 g daily could result in elevated alanine aminotransferase plasma levels a substantial proportion of healthy volunteers. The safety this dose for acute postoperative pain remains controversial. This aimed to examine the incidence elevations after short-term use daily, as part standard management protocol, 93 consecutive patients cardiothoracic surgery. Alanine and other liver function tests were measured preoperatively baseline once...
Purpose. To investigate adherence to our pain protocol considering analgesics administration, number and timing of assessments, adjustment upon unacceptably high (NRS ≥ 4) low ≤ 1) scores. Material Methods. The for patients in the intensive care unit (ICU) after cardiac surgery consisted automated prescriptions paracetamol morphine, reminders a flowchart guide interventions scores, reassessments unacceptable pain. Results. Paracetamol morphine were prescribed all 124 patients. Morphine...
The gold standard for quantification of pain is a person's self-report. However, we need objective parameters measurement when intensive care patients, example, are not able to report themselves. An increase in currently thought coincide with an stress hormones. This observational study investigated whether procedure-related associated plasma cortisol, adrenaline, and noradrenaline. In 59 patients receiving after cardiac surgery, noradrenaline levels were measured immediately before turned...
ABSTRACT Objective: To describe the 12-month mortality of Dutch COVID-19 intensive care unit patients, total population and various subgroups on basis number comorbidities, age, sex, mechanical ventilation, vasoactive medication use. Methods: We included all patients admitted with between March 1, 2020, 29, 2022, from National Intensive Care (NICE) database. The crude rate is presented via Kaplan-Meier survival curves for each patient subgroup. used Cox regression models to analyze effects...
RESUMO Objetivo: Descrever a mortalidade em 12 meses de pacientes holandeses com COVID-19 internados unidades terapia intensiva, população total e vários subgrupos segundo o número comorbidades, idade, sexo, ventilação mecânica uso medicação vasoativa. Métodos: Incluímos todos os admitidos entre 1° março 2020 29 2022, do banco dados registro holandês National Intensive Care Evaluation (NICE). A taxa bruta é apresentada por meio das curvas sobrevida Kaplan-Meier para cada subgrupo pacientes....
Delirium after cardiac surgery is associated with a prolonged length of stay in the ICU, ventilation time and higher in-hospital mortality. Although exact pathophysiology delirium unknown, both use analgesics experience pain have been suggested to be occurrence delirium. The aim study was evaluate association between ICU.
- Subgroup discovery (SGD) is the automated splitting of data into complex subgroups. Various SGD methods have been applied to medical domain, but none extensively evaluated. We assess numerical and clinical quality methods.- improved Set Discovery (SSD++), Patient Rule Induction Method (PRIM) APRIORI (APRIORI-SD) algorithms obtain patient subgroups on observational 14,548 COVID-19 patients admitted 73 Dutch intensive care units. Hospital mortality was outcome. Numerical significance...
We report on a 29-year old woman, gravida 1, para 0, who complained, after 6 weeks of amenorrhoea, vaginal bleeding and acute pain in the lower left abdomen. A non-ruptured ampullary tubal pregnancy was recognised at diagnostic laparoscopy removed by tube-preserving surgery. Subsequently, serum human chorionic gonadotropin (hCG) quantified every two days; rising hCG concentration confirmed persistent ectopic gestation patient. 12 days conservative laparoscopic surgery, treatment with...