A5029370531- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Biosensors and Analytical Detection
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Animal Virus Infections Studies
- Escherichia coli research studies
- COVID-19 diagnosis using AI
- Malaria Research and Control
- Genital Health and Disease
- Genetic factors in colorectal cancer
- Protease and Inhibitor Mechanisms
- HIV/AIDS drug development and treatment
- Trypanosoma species research and implications
- Plant Virus Research Studies
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Phytochemistry and biological activity of medicinal plants
- Microbial infections and disease research
- Dental Research and COVID-19
- Hemoglobinopathies and Related Disorders
- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
Armauer Hansen Research Institute
2020-2024
Kenya Medical Research Institute
2022
All Africa Leprosy Tuberculosis and Rehabilitation Training Centre
2021
Abstract The World Health Organization [WHO] recommends a genotype-specific human papillomavirus [HPV] vaccination as primary prevention strategy to control the burden of cervical cancer globally. In Ethiopia, where non-vaccine-targeted HPV genotypes have not been adequately studied, initiative was launched in 2018 targeting HPV-6,-11, -16, and -18 for girls aged 14–18 years. co-existence both vaccine-targeted non-targeted is serious concern, it can accelerate progression. Therefore, this...
Abstract Scaling up of diagnostic capacity is needed to mitigate the global pandemic SARS-CoV2. However, there are challenges including shortage sample collection swabs and transport medium. Saliva has been recommended as a simple, low-cost, non-invasive option. data from different populations settings limited. Here, we showed that saliva could be good alternative diagnose COVID-19 patients. Pair NPS-saliva samples was collected 152 symptomatic; confirmed patients, compared their positivity...
Cervical cancer is a vaccine-preventable sexually transmitted disease. In the year 2020, there were an estimated 604,000 new cases and 342,000 deaths worldwide. Although its incidence global, it much higher in sub-Saharan African countries. Ethiopia, scarcity of data about prevalence high-risk HPV infection association with cytological profiles. Therefore, this study was conducted to fill information gap. A hospital-based cross-sectional from April 26 August 28, 2021, enrolled 901 active...
Background Diarrhea is a serious health problem in children, with the highest mortality rate sub-Saharan Africa. Diarrheagenic Escherichia coli (DEC) among major bacterial causes of diarrhea children under age five. The present study aims to determine molecular epidemiology and antimicrobial resistance profiles DEC identify contributing factors for acquisition five Central Ethiopia. Methods A facility-centered cross-sectional was conducted Addis Ababa Debre Berhan, Ethiopia, from December...
Background The coronavirus disease 2019 (COVID-19) pandemic has revealed the global public health importance of robust diagnostic testing. To overcome challenge nucleic acid (NA) extraction and testing kit availability, an efficient method is urgently needed. Objectives establish efficient, time resource-saving cost-effective methods, to propose ad hoc pooling approach for mass screening SARS-CoV-2. Methods We evaluated on both direct clinical NA samples. standard reverse transcriptase...
A moderate to high seroprevalence of exposure Newcastle disease (NDV), avian metapneumovirus (aMPV), infectious laryngotracheitis virus (ILTV), bronchitis (IBV) and Mycoplasma gallisepticum (MG) has recently been reported in Ethiopia, but it is unclear what extent these contribute clinical cases respiratory disease. This study investigated the presence pathogens chickens exhibiting two live markets Addis Ababa. Markets were visited weekly for three months, 18 displaying signs acquired. Swab...
We determined the dengue virus (DENV) serotypes and genotypes in archived serum samples that were collected during 2014–2016 2021 outbreaks Dire Dawa City Somali region Ethiopia. DENV serotype 1 (DENV-1) was predominant followed by 2 (DENV-2). Thirteen of DENV-1 strains assigned to Genotype-I, while remaining two found be Genotype-III. All three DENV-2 Cosmopolitan Genotype. The responsible for are genetically closely related circulated neighboring Asian countries. findings also showed...
There have been numerous studies that showed the presence of human papillomavirus (HPV) in breast cancer; nonetheless, there is ongoing debate regarding their association. Given few Ethiopia, we aimed to investigate magnitude HPV infection Ethiopian cancer patients.
Abstract With the widespread use of Integrase strand transfer inhibitors (INSTIs), surveillance HIV-1 pretreatment drug resistance is critical in optimizing antiretroviral treatment efficacy. However, despite introduction these drugs, data concerning their mutations (RMs) still limited Ethiopia. Thus, this study aimed to assess INSTI RMs and polymorphisms at gene locus coding for (IN) among viral isolates from ART-naive infected Ethiopian population. This was a cross-sectional involving...
Abstract Background The coronavirus disease (COVID-19) pandemic has revealed the global public health importance of robust diagnostic testing. To overcome challenge nucleic acid (NA) extraction and testing kit availability efficient method is urgently needed. Objectives establish an efficient, time resource-saving cost-effective methods, to propose ad hoc pooling approach for mass screening SARS-CoV-2 Methods Direct clinical sample NA was used standard reverse transcriptase polymerase chain...
Subclinical human cytomegalovirus (HCMV) replication is associated with immune dysfunction in immuno-suppressed antiretroviral therapy (ART) naive HIV infected individuals. No data documented Ethiopia so far concerning HCMV co-infection among Hence, this study was aimed at generating regarding the prevalence of active infection treatment-naive HIV-infected individuals from Ethiopia. For purpose, we enrolled 97 subjects Addis Ababa June to December 2018. ELISA and conventional PCR were...
Matrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an association between MMP-2, MMP-9, MMP-11 expression clinicopathological characteristics of breast (BC); however, no research has been done on the MMP levels BC cases from Ethiopia.A total 58 formalin-fixed paraffin-embedded tissue samples encompassing 16 benign tumors 42 were collected. The RNA was extracted quantitative reverse-transcription PCR performed....
Clinically diagnosed pulmonary tuberculosis (TB) (CDPTB) patients account for a huge proportion of TB. However, little is known about the genetic diversity and drug resistance profile
Abstract Background: The coronavirus disease (COVID-19) pandemic has revealed the global public health importance of robust diagnostic testing. To overcome challenge nucleic acid (NA) extraction and testing kit availability efficient method is urgently needed. Objectives: establish an efficient, time resource-saving cost-effective methods, to propose ad hoc pooling approach for mass screening SARS-CoV-2 Methods: Direct clinical sample NA was used standard reverse transcriptase polymerase...
Escherichia coli toxins are the most common types found in association with disease E. bacteria. They nearly all pathogenic bacteria either released from or cell both transmitted via orofecal route. The present study evaluated relationship between detected 'improved' drinking water sources and stool samples individuals diarrhea that consumed water. Improved is defined as source, by nature of their construction through active intervention, protected external contamination, particularly fecal...
Three complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from Ethiopian patients were compared with deposited global genomes. Two belonged to genetic group 20A/B.1/GH, and the other 20A/B.1.480/GH. Enhancing genomic capacity is important investigate transmission monitor evolution mutational patterns of SARS-CoV-2 in this country.
Abstract Since the distribution of high-risk HPV genotypes varies across countries, genotype-based vaccination is widely recommended to control burden cervical cancer. As 2018, program underway in Ethiopia for girls aged 9–14 years against HPV-6, HPV-11, HPV-16 and HPV-18. However, rate non-vaccine-targeted are not well characterized. Therefore, by determining prevalence characterizing their genotypes, we assessed level multiple infections with other vaccine-targeted Ethiopia. A health...
Abstract The aim of this study is to evaluate the diagnostic value different clinical samples from humans such as blood/serum, stool, and urine compared routinely used nasopharyngeal swab for detection SARS-CoV2 in COVID-19 patients. We followed patients three weeks collected on occasions that is, day admission hospital (Day zero), after one week (Day-8), second (Day-15). data shows patients, NPS has a 64% positivity rate, by urine, serum, 38%, 18%, 17%, respectively. And we observed nearly...