A5047677747- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Hemoglobinopathies and Related Disorders
- Atrial Fibrillation Management and Outcomes
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Cardiovascular Effects of Exercise
- Blood disorders and treatments
- Viral Infections and Vectors
- Blood Coagulation and Thrombosis Mechanisms
Siriraj Hospital
2019-2024
Mahidol University
2016-2024
Novem (Netherlands)
2024
Royal Children's Hospital
2017
Murdoch Children's Research Institute
2017
Non-valvular atrial fibrillation (AF) is the most common type of cardiac arrhythmia. AF caused by electrophysiological abnormalities and alteration tissues, which leads to generation abnormal electrical impulses. Extracellular vesicles (EVs) are membrane-bound released all cell types. Large EVs (lEVs) secreted outward budding plasma membrane during activation or stress. lEVs thought act as vehicles for miRNAs modulate cardiovascular function, be involved in pathophysiology diseases (CVDs),...
Background Nonvalvular atrial fibrillation (AF) is the most common cardiac arrhythmia, and it associated with prothrombotic state. Circulating microparticles (cMPs) are membrane vesicles that shed from many cell types in response to activation apoptosis. Several studies reported cMPs may play a role hypercoagulable state can be observed patients AF. The aim of this study was determine levels total characterize their cellular origins AF patients. Methods Atotal 66 33 healthy controls were...
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. Diabetes mellitus (DM) one of risk factors for development stroke and thromboembolism in patients with AF. Early identification may reduce incidence complications mortality AF patients.AF DM have different pattern small extracellular vesicle (sEV) levels sEV-derived microRNA (miRNA) expression compared those without DM.We sEV sEV-miRNA plasma from using nanoparticle tracking analysis droplet digital polymerase chain reaction,...
Summary Splenectomised β‐thalassaemia/haemoglobin E (HbE) patients have increased levels of circulating microparticles or medium extra‐cellular vesicles (mEVs). The splenectomised mEVs play important roles in thromboembolic complications since they can induce platelet activation and endothelial cell dysfunction. However, a comprehensive understanding the mechanism mEV generation thalassaemia disease has still not been reached. Thalassaemic are hypothesised to be generated from cellular...
Doxorubicin (DOXO)-induced cardiomyopathy (DIC) is a lethal complication in cancer patients. Major mechanisms of DIC involve oxidative stress cardiomyocytes and hyperactivated immune response. Extracellular vesicles (EVs) mediate cell-cell communication during stress. However, functions circulating EVs released after chronic DOXO exposure on cells are still obscured. Herein, we developed vivo model using male Wistar rats injected with 3 mg/kg for 6 doses within 30 days (18 cumulative dose)....
Abstract Introduction Microvesicles (MVs) are bioactive, submicron‐sized (0.01‐1000 nm) membrane vesicles released from various types of cells under normal physiological and pathophysiological conditions. MVs have emerged as important mediators cell‐to‐cell communication in a diverse range pathological processes. been recognized potential biomarkers coagulation, inflammation, cancer. However, for clinical use, minimizing factors which could affect enumeration phenotypic characterization...