A5084212784- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Cerebrospinal fluid and hydrocephalus
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Diabetes Management and Research
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Neuroblastoma Research and Treatments
- Adrenal Hormones and Disorders
- Meningioma and schwannoma management
- Cardiovascular Syncope and Autonomic Disorders
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
- Eating Disorders and Behaviors
- Coronary Artery Anomalies
- Venous Thromboembolism Diagnosis and Management
- Health Promotion and Cardiovascular Prevention
- Ophthalmology and Visual Health Research
- Clinical Nutrition and Gastroenterology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Pittsburgh Medical Center
2015-2024
University of Pittsburgh
2014-2023
Aga Khan University
2007
Aga Khan University Hospital
2005
Aga Khan University
2004
Abstract Background Knowledge about coronary heart disease (CHD) and its risk factors is an important pre-requisite for individual to implement behavioral changes leading towards CHD prevention. There scant data on the status of knowledge in general population Pakistan. The objective this study was assess a broad Pakistani identify associated with knowledge. Methods Cross sectional carried out at four tertiary care hospitals Pakistan using convenience sampling. Standard questionnaire used...
In view of the increasing popularity complementary and alternative medicine (CAM), it is imperative that medical students, health professionals tomorrow, possess adequate knowledge on topic.This a descriptive study designed to assess knowledge, attitudes behavior students about CAM capture their perceptions opinions its integration into curriculum.A questionnaire-based cross-sectional survey was done 198 selected randomly from Pakistani college. Associations between different variables were...
This report describes a case of pituitary apoplexy with rapidly evolving hemorrhage in 74-year-old female coronavirus disease 2019 (COVID-19) disease. The patient presented severe headache and mild respiratory symptoms, laboratories concerning for hypofunction. Brain imaging demonstrated sellar mass adenoma ischemic apoplexy. She subsequently developed visual deficits within 24 hours presentation, repeat new effect on the optic chiasm. was successfully managed urgent endoscopic endonasal...
Hyperglycemia during sepsis is associated with increased organ dysfunction and higher mortality. The role of the host immune response in development hyperglycemia remains unclear. We performed a retrospective analysis critically ill adult septic patients requiring mechanical ventilation (n = 153) to study relationship between ten markers injury measured on first day ICU admission (baseline). determined associations each biomarker and: (1) glucose, insulin, c-peptide levels at time collection...
BACKGROUND AND OBJECTIVE: Conventional protocols for inferior petrosal sinus sampling (IPSS) during the workup of hypercortisolemia require adrenocorticotrophic hormone (ACTH) measurement at multiple time points with corticotropic-releasing (CRH) used as a stimulator. Modernized evidence-based must also reflect increased utilization desmopressin (DDAVP) ACTH stimulation manufacturing shortage traditionally CRH continues. We model diagnostic accuracy and potential economic savings DDAVP...
Abstract Background Very low‐calorie diets (VLCDs) employing total meal replacement (TMR) offer substantial short‐term weight loss. Concurrently, anti‐obesity medications (AOMs) have shown promise as adjunctive treatments when combined with VLCDs. Aims This study aimed to investigate the impact of adjuvant AOMs on loss and regain within a comprehensive lifestyle program. Methods is retrospective patients obesity enrolled in VLCD/TMR programs, specifically OPTIFAST Results Data from 206 (68%...
Background: The incidence of pituitary adenomas rises with age, leading to increased overall prevalence. Understanding the role surgery for nonfunctional (NFPAs) in elderly, especially increasingly used endoscopic endonasal approach (EEA) requires further study. A growing body research has demonstrated that frailty is a greater predictor poor outcomes than advanced age.
Abstract Introduction: Spontaneous Adrenal Hemorrhage (SAH) in pregnancy is a rare occurrence with estimated prevalence of 0.03% to 1.8%. SAH usually involves the right gland and can be easily mistaken other conditions due its nonspecific symptoms. We hereby report 2 cases spontaneous bilateral that occurred during 3rd trimester pregnancy. Case 1: 28-year-old female history IBS presented 35th week her first right-sided abdominal pain. Abdominal MRI revealed 4.7 x 2.8 cm adrenal hemorrhage....
Non-islet cell tumor hypoglycemia (NICTH) is an uncommon paraneoplastic syndrome associated with mesenchymal neoplasms such as gastrointestinal stromal tumors (GISTs). We report the case of a patient type 1 diabetes (T1D) and recurrent GIST who not only required discontinuation insulin therapy but also continuous parenteral glucose infusions to prevent hypoglycemia.A 59-year-old woman 24-year history T1D presented frequent episodes symptomatic despite reductions in her therapy. Laboratory...
The pathologic spectrum of diseases that infiltrate the pituitary infundibulum includes a broad variety clinical entities. There are significant differences in prevalence these etiologies depending on age presentation. Lymphocytic infundibuloneurohypophysitis (LINH) predominates over other causes infundibular disease adults 21. Differentiating LINH from can be difficult because various often have similar presentations and radiologic imaging characteristics. We report first case an adult...
Abstract Regulation of the growth hormone (GH) axis is complex and influenced by factors including age nutritional status. Studies individuals across weight spectrum demonstrate an inverted U-shaped correlation between BMI total IGF-1 levels; in both with anorexia nervosa-range BMIs those who are severely obese, levels low. Acromegaly a disorder GH/IGF-1 characterized excess secondary to autonomous GH secretion. The relationship has not been well studied acromegaly whether association...
Abstract Introduction: Hypoglycemia is a rare paraneoplastic manifestation of several non-islet cell tumors (NICT) that rarely reported in individuals with diabetes. We report the first case patient type 1 diabetes (T1D) and recurrent gastrointestinal stromal tumor (GIST) who required discontinuation all insulin therapy continuous parenteral glucose infusions to avoid hypoglycemia. Case: The an underweight (BMI 14.9 kg/m2) 59-year-old female 24-year history T1D treated pump was diagnosed...
Background: Pituitary adenomas account for ~10 to 20% of all intracranial tumors, and nonfunctional (NFA) are the second most common subtype. NFA recurrence is common, particularly following incomplete resection, has been reported as 12 58% within 5 years. The endoscopic endonasal approach (EEA) become mainstay treatment symptomatic NFAs, but there a paucity data describing unique challenges documenting clinical outcomes NFAs redo EEA after prior transsphenoidal surgery.