A5046420395- Magnesium Alloys: Properties and Applications
- Nanoplatforms for cancer theranostics
- Diabetes Management and Research
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Pituitary Gland Disorders and Treatments
- Aluminum Alloys Composites Properties
- Diabetes Management and Education
- Cancer Cells and Metastasis
- Bone Tissue Engineering Materials
- Corrosion Behavior and Inhibition
- Phosphodiesterase function and regulation
- Cancer Treatment and Pharmacology
- Virus-based gene therapy research
- Glycosylation and Glycoproteins Research
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Tuberous Sclerosis Complex Research
- Environmental remediation with nanomaterials
- Advanced oxidation water treatment
- Polymer Nanocomposite Synthesis and Irradiation
Indian Institute of Technology Roorkee
2023-2024
University of Pittsburgh Medical Center
2020-2024
Indian Institute of Technology Delhi
2018-2023
University of Pittsburgh
2023
UPMC McKeesport
2019-2022
All India Institute of Medical Sciences
1982-2021
Institute of Medical Sciences
2021
Ludwig-Maximilians-Universität München
2019
Center for NanoScience
2019
Safdarjang Hospital
2015-2018
The removal of dichlorvos contamination from water is a challenging task because the presence direct carbon to phosphorous covalent bond, which makes them resistant chemical and thermal degradation. Although there have been reports in literature for degradation using nanomaterials, those are based on photocatalysis. In this paper, we report simple rapid method catalytic protein-capped zero valent iron nanoparticles (FeNPs). We developed an unprecedented reliable, clean, nontoxic,...
This case report describes a unique occurrence of rheumatic heart disease (RHD) with severe mitral, tricuspid, and pulmonary stenosis in 17-year-old female. The patient presented progressive exertional dyspnea dependent edema. She had history acute fever joint pain 5 years ago. Evidence congestive failure, such as pitting pedal edema, hepatomegaly, elevated jugular venous pressure, was noted on presentation. electrocardiogram (ECG) revealed important diagnostic information signs consistent...
B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs; however, there are presently no agents target BCL2A1. The MUC1-C oncoprotein aberrantly expressed in triple-negative breast cancer (TNBC) cells, induces epithelial-mesenchymal transition (EMT) and promotes drug resistance. present study demonstrates targeting genetically pharmacologically TNBC cells results downregulation BCL2A1...
Abstract Non-viral gene delivery is constrained by the dwell time that most synthetic nucleic acid nanocarriers spend inside endosomal compartments. In order to overcome this endosomal-release bottleneck, methods are required measure nanocarrier uptake kinetics and transfection efficiency simultaneously. Here, we employ live-cell imaging on single-cell arrays (LISCA) study delivery-time distribution of lipid-based mRNA complexes under varied serum conditions. By fitting a...
The current work takes the benefit of utilizing a composite approach by reinforcing Mg with Zn, Cerium oxide - rare earth and bone-friendly ceramic, bioactive hydroxyapatite to develop magnesium-based MMCs for high structural integrity low degradation inside human body via stir casting technique in protective Ar-SF6 environment. friction processing (FSP) was employed tailor properties as-cast composites, resulting further grain refinement better dispersion reinforced materials. Phase...
OBJECTIVE The traditional treatment of sellar Rathke cleft cysts (RCCs) generally involves transsellar drainage; however, suprasellar RCCs present unique challenges to appropriate management and technical complexity. Reports on overall outcomes for the endoscopic endonasal approach (EEA) this pathology are limited. EEA allows three surgical techniques: marsupialization, fenestration, fenestration with cyst wall resection. METHODS authors performed a retrospective review consecutive patients...
Multiple studies have shown that the progression of breast cancer depends on multiple signaling pathways, suggesting therapies with multitargeted anticancer agents will offer improved therapeutic benefits through synergistic effects in inhibiting growth. Dual-targeted inhibitors phosphoinositide 3-kinase (PI3-K) and histone deacetylase (HDAC) emerged as promising therapy candidates. However, poor aqueous solubility bioavailability limited their efficacy cancer. The present study investigates...
Background: Diabetes self-management education and support (DSMES) is a critical component of diabetes care, but time for it often limited. Digital tools, such as mobile applications (apps), show promise in extending efforts supporting education, have not been fully used. Objectives this multi-phase study were to (1) evaluate an app designed patients with insulin therapy (2) examine provider perspectives on DSMES apps. Methods: Phase 1: Thirty-two adult type 2 new or having difficulties...
A 2-year-old male child presented with a painless progressive mass in the inferolateral aspect of right orbit three-month duration. Differential leucocyte count revealed raised eosinophil (13%). On radiological examination, CT scan showed 25 × 27 mm round well-defined smooth-outlined homogenously enhancing extraconal arising from zygomatic bone at inferotemporal periorbital area erosion. Histopathological examination incision biopsy characteristic Langerhans cells and immunohistochemical...
Zn, a biodegradable metal, exhibits immense capability as bioresorbable implant material because of its remarkable biocompatibility and stronger corrosion resistance than Mg. Nonetheless, Zn's limited mechanical strength hardness have significantly hindered widespread implementation. This study aimed to strengthen the mechanical, degradation resistance, zinc composites by rolling them investigating impact Mn content on properties Zn composites. The prepared hot rolled Zn-1.5Mg-0.5HA-1.5Mn...
Copper-based sulfides are attractive candidates for NIR I and II responsive photothermal therapy but often suffer from high hydrophobicity, suboptimal conversion, poor biostability biocompatibility. In the present work, a rapid, one-pot synthesis method was developed to obtain Au-doped Cu1.92S (ACSH NDs) dual plasmonic nanodots. ACSH NDs exhibit excellent peroxidase-like catalytic activity pH-responsive •OH radical generation along with efficient glutathione depletion under tumor...