A5039935199- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Hematopoietic Stem Cell Transplantation
- Genomic variations and chromosomal abnormalities
- Cardiac electrophysiology and arrhythmias
- Protein Degradation and Inhibitors
- Retinoids in leukemia and cellular processes
- Immunodeficiency and Autoimmune Disorders
- 3D Printing in Biomedical Research
- Eosinophilic Disorders and Syndromes
- Neutropenia and Cancer Infections
- Multiple Myeloma Research and Treatments
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Bone and Joint Diseases
- Hematological disorders and diagnostics
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Vascular Tumors and Angiosarcomas
- Parental Involvement in Education
Boston Public Schools
2022
Policlinico San Matteo Fondazione
2008-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2019
Curtin University
2018
University of Pavia
2006-2017
University of Milan
1968
The aim of this study was to evaluate the prognostic value WHO proposal, assess role main factors in myelodysplastic syndromes (MDSs) classified into subgroups, and estimate mortality (standardized ratio [SMR]) life expectancy these groups as a basis for clinical decision making.Four hundred sixty-seven patients who were diagnosed having de novo MDS at Division Hematology, University Pavia (Pavia, Italy), between 1992 2002, evaluated retrospectively hematologic features diagnosis, overall...
Summary This study correlated chromosomal defects with French–American–British (FAB)/World Health Organization (WHO) classification subtypes, proposed a revised International Prognostic Scoring System (IPSS) cytogenetic grouping; and established which classification, when used the IPSS categories, best predicted clinical outcome in myelodysplastic syndromes (MDS). A higher prevalence of distinct were observed patients multi‐lineage dysplasia blast cell percentage >10%. Abnormalities long...
Transcribed gene fusions are key biomarkers in many hematologic and solid tumors, often representing the primary oncogenic driver mutation. Here, we report an experimental computational pipeline for detecting fusion transcripts using single-molecule RNA FISH unbiased correlation analysis (FuseFISH). We constructed a genome-wide database of optimal oligonucleotide sequences, enabling quick design FuseFISH probes against known novel fusions. implemented cell lines, tissue sections, purified...
Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess effects. A sizable number trials conducted over years generated only weak evidence backing current recommendations, as shown systematic reviews on old-world and new-world CL (OWCL NWCL).Using a previously published guidance paper trial methodology reference, consensus was sought key parameters including core eligibility outcome measures, among OWCL (7 countries, 10...
Abstract One hundred eighty‐eight unselected consecutive patients with “de novo” myelodysplastic syndrome (MDS) were studied cytogenetically. They subclassified as 4 refractory anemia ringed sideroblasts (RARS), 67 (RA), 58 excess of blasts (RAEB), 40 RAEB in transformation (RAEB‐t), and 19 chronic myelomonocytic leukemia (CMML). The overall incidence chromosome abnormalities was 69%. RAEB‐t showed karyotypic changes, more often than RA CMML (76% 100% vs. 56% 42%, respectively). most...
Summary Fanconi anaemia ( FA ) is an inherited disorder characterized by pancytopenia, congenital malformations and a predisposition to develop malignancies. Alterations in the haematopoietic microenvironment of patients have been reported, but little known regarding components their bone marrow BM stroma. We mesenchymal stromal cells MSC s) isolated from 18 both before after allogeneic stem cell transplantation HSCT ). Morphology, fibroblast colony‐forming unit CFU ‐F) ability,...
This study analyzed 140 patients with isolated del13q14 on interphase FISH (I-FISH), to identify subsets a different progression risk and assess the acquisition of additional chromosomal abnormalities (clonal evolution) in treatment-naïve patients. A monoallelic deletion (del13qx1) was detected 123 cases (88%), biallelic (del13qx2) eight mosaic deletions (del13qx1/del13qx2) nine. In 33% cases, encompassed Rb1 locus The median percentage abnormal nuclei 50% (15%-96%), it higher...
This study evaluated whether the NCCSS truly improves prognostic stratification of 630 consecutive de novo MDS patients and established which cytogenetic grouping [NCCSS or International Prognostic Scoring System (IPSS)], when combined with WHO classification, best predicted clinical outcome myelodysplastic syndromes (MDS). The frequency chromosomal defects was 53.8%. Clinical parameters, including number cytopenias, IPSS categories scores, were all relevant for overall survival (OS)...
Abstract Splenic hematopoiesis is a major feature in the course of myelofibrosis (MF). In fact, spleen patients with MF contains malignant hematopoietic stem cells retaining complete differentiation program, suggesting both pivotal role maintaining disease and tight regulation by splenic microenvironment, particular mesenchymal stromal (MSCs). Little known about MSCs (Sp‐MSCs), normal pathological context. this work, we have vitro expanded characterized Sp‐MSCs from 25 13 healthy subjects...
Introduction The association between congenital pulmonary airway malformations (CPAM) and malignancy is reported in the literature. Interactions tumor, immune, mesenchymal stromal/stem cells (MSCs) have been recognized as crucial for understanding tumorigenesis. We characterized MSCs isolated from CPAM lesions order to define potential risks. Methods II tissue was used MSC expansion; a "healthy" lung section same child comparator. Morphology, immunophenotype, differentiation immunological...