A5068638377- Research on Leishmaniasis Studies
- Parasitic Diseases Research and Treatment
- Mycobacterium research and diagnosis
- Platelet Disorders and Treatments
- Parasites and Host Interactions
- Infectious Diseases and Mycology
- Innovation and Socioeconomic Development
- Humic Substances and Bio-Organic Studies
- Circadian rhythm and melatonin
- Autoimmune Bullous Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Trypanosoma species research and implications
- Gastroesophageal reflux and treatments
- Leptospirosis research and findings
- Disaster Response and Management
- Genomics and Phylogenetic Studies
- Genetic Syndromes and Imprinting
- Health Policy Implementation Science
- Plant and Fungal Interactions Research
- Prion Diseases and Protein Misfolding
- Air Quality and Health Impacts
- Monoclonal and Polyclonal Antibodies Research
- IgG4-Related and Inflammatory Diseases
- Human-Animal Interaction Studies
- Veterinary Practice and Education Studies
Medical University of Vienna
2018-2024
Infectious Diseases Data Observatory
2024
University of Oxford
2015-2023
Angkor Hospital for Children
2018
University of Freiburg
2015
UiT The Arctic University of Norway
2014
Institute for Social Anthropology
2009
University of Vienna
2009
Over the last decades, genus Streptomyces has stirred huge interest in scientific community as a source of bioactive compounds. The majority all known antibiotics is isolated from these bacterial strains, well variety other drugs such antitumor agents, immunosuppressants and antifungals. To best our knowledge, StreptomeDB was first database focusing on compounds produced by streptomycetes. new version presented herein represents major step forward: its content been increased to over 4000...
Exposure to food and environmental contaminants is a global health issue. In this study, innovative LC-MS/MS approaches were applied investigate mycotoxin co-exposure in mother-infant pairs (n = 23) by analyzing matched plate-ready food, breast milk urine samples of mothers their exclusively breastfed infants. The study revealed frequent co-occurrence two five mycotoxins. Regulated (e.g. aflatoxins, deoxynivalenol ochratoxin A) emerging mycotoxins alternariol monomethyl ether beauvericin)...
Abstract Breast cancer is highly prevalent yet a more complete understanding of the interplay between genes and probable environmental risk factors, such as night work, remains lagging. Using discordant twin pair design, we examined association shift work breast risk, controlling for familial confounding. Shift pattern was prospectively assessed by mailed questionnaires among 5,781 female twins from Older Finnish Twin Cohort. Over study period (1990–2018), 407 incident cases were recorded...
Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess effects. A sizable number trials conducted over years generated only weak evidence backing current recommendations, as shown systematic reviews on old-world and new-world CL (OWCL NWCL).Using a previously published guidance paper trial methodology reference, consensus was sought key parameters including core eligibility outcome measures, among OWCL (7 countries, 10...
Background In Brazil, case-fatality from visceral leishmaniasis (VL) is high and characterized by wide differences between the various political-economic units, federated units (FUs). This study was designed to investigate association factors at both FU individual levels with risk of dying VL, after analysing temporal trend spatial dependency for VL case-fatality. Methodology The analysis based on aggregated data Reportable Disease Information System-SINAN (Brazilian Ministry Health)....
Although non-fatal and mostly self-healing in the case of Leishmania (L.) major, cutaneous leishmaniasis (CL) is mainly treated to reduce lesion healing time. Less attention paid improvement scars, especially aesthetically relevant areas body, which can dramatically affect patients' wellbeing. We explored perspectives about treatment options social psychological burden disease (lesion scar). Individual in-depth interviews were conducted with ten confirmed CL patients at two L. major endemic...
Cutaneous leishmaniasis (CL) is a disease that often affects exposed skin areas and may heal leaving lifelong scars. Patients' expectations from treatment are rarely considered in drug development for CL. An initiative aiming to address shortcomings clinical trial design conduct CL treatments involving the researchers' community on-going. This manuscript presents patient-preferred outcomes an assessment on how consider these of future trials.We report preferred by 74 patients with confirmed...
Lack of investments in drug development, lack standardisation clinical trials and the complexity disease presentations contribute to current effective, safe adapted treatments for cutaneous leishmaniasis (CL). One aspect concerns outcomes affecting patients' quality life (QoL): these are hardly assessed trials, despite potential functional and/or aesthetic impairment caused by CL, which typically affects disadvantaged vulnerable people living rural areas. Here, we describe approach used...
To date, pregnant women are excluded from programmes delivering community-directed treatment of ivermectin (CDTI) for onchocerciasis and preventive chemotherapy other helminthiases because concerns over safety during pregnancy. This systematic exclusion sustains an infection reservoir at the community level deprives a vulnerable population known benefits-there indications that treating O. volvulus infected may improve pregnancy outcomes reduce risk their children develop...
Only few longitudinal studies with high risk of bias have examined relationship between pets and adolescents' mental health.
Nightshift work is a plausible risk factor for hematologic cancer, but epidemiological evidence remains sparse, especially individual subtypes. We prospectively examined the association of rotating nightshift with hematopoietic cancer risk.This cohort study included US women from Nurses' Health Study (NHS: n = 76 846, 1988-2012) and II (NHSII: 113 087, 1989-2013). Rotating duration was assessed at baseline (both cohorts) cumulatively updated (NHSII). Cox regression used to estimate hazard...
Background and purpose The use of proton‐pump inhibitors (PPIs) was reported to be associated with increased mortality risk has been proposed as a potential factor for neurodegenerative diseases. We aimed assess the impact PPI on survival in patients dementia compared controls. Methods This register‐based control‐matched cohort study included 28 428 ascertained by prescription antidementia drugs two control individuals matched sex, age area residence each patient during period from 1 January...
Background Target Product Profiles (TPPs) are instrumental to help optimise the design and development of therapeutics, vaccines, diagnostics – these products, in order achieve intended impact, should be aligned with users’ preferences needs. However, patients rarely involved as key stakeholders building a TPP. Methodology Thirty-three cutaneous leishmaniasis (CL) from Brazil, Colombia, Austria, infected New-World Leishmania species, were recruited using maximum variation approach along...
INTRODUCTION Buruli ulcer caused by Mycobacterium ulcerans is a devastating necrotic skin disease. PCR, recommended for confirmation of WHO, requires an adequately equipped laboratory, often delaying diagnosis and treatment patients in remote or humanitarian settings. We aimed to assess loop- mediated isothermal amplification (LAMP), which molecular assay DNA suggested timely low-resource METHODS This study combines quantitative qualitative methods. First, we evaluated simple rapid syringe...
Introduction Buruli ulcer (BU) caused by Mycobacterium ulcerans (MU) is a devastating necrotic skin disease. PCR, recommended for confirmation of BU WHO, requires an adequately equipped laboratory, therefore often delaying timely diagnosis and treatment patients in remote settings. Loop-mediated isothermal amplification (LAMP) PCR-based protocol DNA that has been suggested low-resource Study aims methods This exploratory diagnostic test evaluation study, with embedded qualitative sub-study....
Background Clinical trials are often perceived as being expensive, difficult and beyond the capacity of healthcare workers in low-resource settings. However, order to improve coverage, World Health Organization (WHO) Report 2013 stated that all countries need become generators well recipients data. This study is a methodological examination steps processes involved setting up Gojjam Lymphoedema Best Practice Trial (GoLBeT; ISRCTN67805210), highly pragmatic clinical trial conducted northern...
Importance Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, rapidly progressive and fatal neurodegenerative disease. Definite sCJD diagnosis can only be made post mortem, little known about the prodromal phase of Objective To compare drug prescription patterns before clinical onset between patients matched controls for exploration potential risk factors to assess correlations exposure survival. Design, Setting, Participants This retrospective analysis was designed as case-control study,...