A5003990088- Extracellular vesicles in disease
- Traditional Chinese Medicine Analysis
- Atherosclerosis and Cardiovascular Diseases
- Autophagy in Disease and Therapy
- Renin-Angiotensin System Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Transgenic Plants and Applications
- MicroRNA in disease regulation
- Plant tissue culture and regeneration
- Animal Genetics and Reproduction
- Heart Rate Variability and Autonomic Control
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Spinal Cord Injury Research
- Reproductive System and Pregnancy
- Phytochemistry and Biological Activities
- Blood Pressure and Hypertension Studies
- Ferroptosis and cancer prognosis
- Caveolin-1 and cellular processes
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Inflammasome and immune disorders
Hebei University of Chinese Medicine
2019-2024
Brock University
2007
Academy of Military Medical Sciences
2002
Institute of Pharmacology
2002
Wonkwang University
2002
Abstract Parkinson’s disease (PD) is a progressively debilitating neurodegenerative condition that leads to motor and cognitive dysfunction. At present, clinical treatment can only improve symptoms, but cannot effectively protect dopaminergic neurons. Several reports have demonstrated human umbilical cord mesenchymal stem cells (hucMSCs) afford neuroprotection, while their application limited because of uncontrollable differentiation other reasons. Stem communicate with through secreted...
Microglia-mediated inflammatory responses have been shown to play a crucial role in Parkinson's disease. In addition, exosomes derived from mesenchymal stem cells anti-inflammatory effects the treatment of variety diseases. However, whether they can protect neurons disease by inhibiting microglia-mediated is not yet known. this study, were isolated human umbilical cord and injected into 6-hydroxydopamine-induced rat model We found that through tail vein lateral ventricle absorbed...
Parkinson's disease (PD) is a progressive neurological disorder characterized by loss of neurons that synthesize dopamine, and subsequent impaired movement. Umbilical cord mesenchymal stem cells (UC-MSCs) exerted neuroprotection effects in rodent model PD. However, the mechanism underlying UC-MSC-generated was not fully elucidated. In present study, we found intranasal administration UC-MSCs significantly alleviated locomotor deficits rescued dopaminergic inhibiting neuroinflammation PD...
Alzheimer's disease (AD), the most common cause of dementia, is a neurodegenerative disorder characterized by amyloid plaque accumulations, intracellular tangles and neuronal loss in certain brain regions. It has been shown that disturbance normal iron metabolism contributes to pathophysiology AD. However, mechanism underlying abnormal load AD patients unclear. The frontal cortex, an important structure for executive function, one regions affected We investigated beneficial effects active...
Background: Hypertension is a major risk factor for cardiovascular diseases and the leading cause of mortality worldwide. Despite availability antihypertensive drugs, alternative treatments are needed due to adverse events associated with their use. Previous studies have shown that SABP, combination aqueous active metabolites Salvia Miltiorrhiza Bunge DSS, Sal-A, Sal-B PAL, has significant effect. However, underlying mechanisms remain unknown. Objective: This study aimed determine effects...
Abstract Small extracellular vesicles (sEVs) secreted by human umbilical cord have therapeutic effects on various degenerative diseases. However, the characteristics and potential functions of mesenchymal stem cells (huMSCs)‐derived sEVs, especially role premature ovarian failure (POF), are poorly understood. Here, we isolated characterized huMSCs their sEVs. highly expressed CD73, CD90, CD105. huMSC‐sEVs showed typical exosomal features, expressing CD9, TSG101, CD63. It was shown that could...
Salvia miltiorrhiza (SM) contains four major aqueous active ingredients, which have been isolated, purified and identified as danshensu (DSS), salvianolic acid A (Sal-A), B (Sal-B) protocatechuic aldehyde (PAL), mixture of these ingredients is called SABP. Although extract from has traditionally used to treat cardiovascular diseases, the efficacy function optimal ratio SABP in preventing treating diseases remain unknown. This study aims explore antiinflammatory mechanisms underlying...
Abstract Apolipoprotein A-I Milano (Apo ) is a natural mutant of Apolipoprotein. It currently the only protein that can clear arterial wall thrombus deposits and promptly alleviate acute myocardial ischemia. Apo considered as most promising therapeutic for treating atherosclerotic diseases without obvious toxic or side effects. However, current biopharmaceutical platforms are not efficient developing . The objectives this research were to express using genetic transformation ability N....
Abstract The human insulin gene modified with a C-peptide was synthesized according to the plant-preferred codon, and fusion expression vector of combined green fluorescent protein (GFP) constructed. optimization flax callus culturing undertaken, more efficient Agrobacterium -mediated genetic transformation hypocotyls achieved. critical concentration values hygromycin on hypocotyl development, as well its differentiated callus, were explored by method antibiotic gradient addition,...
Objective: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with symptoms including tremor and bradykinesia, while traditional dopamine replacement therapy hypothalamic deep brain stimulation can temporarily relieve patients’ symptoms, they cannot cure the disease. Hence, discovering new methods crucial to designing more effective therapeutic approaches address condition. In our previous study, we found that exosomes (Exos) derived from human umbilical cord mesenchymal...
Salvia miltiorrhiza (SM) is a traditional Chinese medicine used clinically to treat cardiovascular diseases, including atherosclerosis and myocardial infarction. Its therapeutic effect has been confirmed by many clinical pharmacological studies. However, the optimal formulation of active ingredients in SM for treating diseases remains unclear. In this study, we determined ratio compatibility DSS, Sal-A, Sal-B, PAL (SABP)with uniform orthogonal optimized experimental design. addition,...
Our objective was to determine if superoxide anion mediates endothelin-1 (ET-1) expression in adventitial fibroblasts response angiotensin II (Ang II). Vascular were isolated from mouse aorta, preproET-1 messenger RNA (mRNA) levels determined by relative RT-PCR and procollagen protein measured Western blot. Adventitial treated with or without Ang (10−7M) antioxidants dismutase (SOD) (350 U/ml), tempol (10−5M), tiron (10−5M). significantly increased mRNA while treatment decreased both...
Recent studies have demonstrated that under Angiotensin II (Ang II) treatment, adventitial fibroblasts are able to express Endothelin-1 (ET-1), a result which led increased collagen I expression. However, mediation of the Ang induced ET-1 expression through NADPH oxidase in remains uncertain. The purpose present study was determine if mediates Vascular were isolated mouse aorta and treated with (10-7 M) presence or absence apocynin (10-5M), specific inhibitor. PreporET-1 mRNA determined by...
Abstract Parkinson's disease (PD) is a neurodegenerative characterized by dyskinesia and related to microglia-mediated pyroptosis. Stem cell-derived exosomes have small size, low immunogenicity, the ability of transferring effective substances stem cells freely. In this study, were isolated from human umbilical cord mesenchymal (hucMSCs) injected into PD rats induced 6-hydroxydopamine (6-OHDA). We found that absorbed dopaminergic neurons microglia in affected side exosome treatment inhibited...
Abstract Aim of the Study Aqueous extract from Salvia Miltiorrhiza has been traditionally used to treat cardiovasulcar diseases. This study aims explore anti-inflammatory mechanisms underlying attenuation atherosclerosis development by aqueous Miltiorrhiza. Materials and methods Male ApoE-/- mice were randomly allocated into model, SABP, rosuvastatin calcium groups (RC). After 8-wk-treatment, lipid profiles in serum, lactate dehydrogenase (LDH), creatine kinase (CK) heart tissue measured...