A5039498875- Mast cells and histamine
- Cancer Immunotherapy and Biomarkers
- Click Chemistry and Applications
- Polyamine Metabolism and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Retinal and Optic Conditions
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Gut microbiota and health
- Immune cells in cancer
- PI3K/AKT/mTOR signaling in cancer
- Veterinary Oncology Research
- Ocular Diseases and Behçet’s Syndrome
- Fibroblast Growth Factor Research
- Colorectal Cancer Treatments and Studies
- Urinary Bladder and Prostate Research
- Bariatric Surgery and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Retinal and Macular Surgery
- Tannin, Tannase and Anticancer Activities
- Peripheral Neuropathies and Disorders
- Diabetes Treatment and Management
- ATP Synthase and ATPases Research
Istituto Tumori Bari
2010-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Institute of Ophthalmology
1976
University of Bari Aldo Moro
1976
During the last decade, a new therapeutic revolution has involved management of hepatocellular carcinoma (HCC). This is made possible thanks to documented efficacy immunotherapy for this disease. In addition, evidence demonstrated role gut-liver axis and gut microbiota in host homeostasis, tumor development, response therapies. particular, intestinal dysbiosis can alter microenvironment leading activation intracellular signalling pathways that promote carcinogenesis. The composition proved...
During the last decade, a new therapeutic revolution has involved management of hepatocellular carcinoma (HCC). This is made possible thanks to documented efficacy immunotherapy for this disease. In addition, evidence demonstrated role gut–liver axis and gut microbiota in host homeostasis, tumor development, response therapies. particular, intestinal dysbiosis can alter microenvironment, leading activation intracellular signaling pathways that promote carcinogenesis. The composition proved...
Mast cells (MCs) contain proangiogenic factors, in particular tryptase, associated with increased angiogenesis several tumours. With special reference to pancreatic cancer, few data have been published on the role of MCs both ductal adenocarcinoma tissue (PDAT) and adjacent normal (ANT). In this study, density mast positive for c-Kit receptor (MCDP-c-KitR), tryptase (MCDPT), area (MCAPT), terms microvascular (MVD) endothelial (EA) were evaluated a total 45 PDAT patients stage T2-3N0-1M0.For...
Inflammatory cells are emerging markers in various cancers human trials. The relationship between the inflammatory response, cancer grade, and progression has been investigated experimentally a spontaneous canine model of breast unselected population (18-64 years.o.) under anti-HER2 treatments that represent most prevalent this type. data (N samples = 101) were collected retrospectively for diagnosis our regional area evaluated by immunohistochemistry haemato-chemistry. immune-related...
Mast cells (MCs) are known to be involved in several physiological and pathological processes humans animals. Recently, their potential role tumor development angiogenesis has been investigated, arising interesting results potentially applied clinics. cells' granules contain a huge quantity of protease enzymes that, through different mechanisms, induce the formation new microvessels, feeding burden. Among them, tryptase chymase most abundant enzymes: is well for its multiple activities, on...
Soft tissue sarcomas are a large group of different tumor types both in humans and animals. Among them, fibrosarcoma is the most frequent malignant mesenchymal tumoral form cats, representing up to 28% all cat skin tumors, while human fibrosarcoma, fortunately, only represents 5% 0.025% world-wide burden tumors. This low incidence leads consideration this diseases as rare, so therapeutic options few due difficulty starting clinical trials. In context, identification research models for...
Case Reports| March 26 2010 Destructive and Conservative Treatment of Persistent Hyperplastic Primary Vitreous Retinal Dysplasia G. Scuderi; Scuderi Institute Ophthalmology (Head: Prof. Scuderi), Bari University, Search for other works by this author on: This Site PubMed Google Scholar E. Balestrazzi; Balestrazzi Ranieri Ophthalmologica (1976) 172 (4): 346–352. https://doi.org/10.1159/000307733 Article history Published Online: Content Tools Views Icon contents Figures & tables Video Audio...
The advent of vaccines has drastically reduced the incidence, morbidity, and mortality related to COVID-19, with increase in number vaccinated subjects, there have been reports some adverse events, including skin reactions. In this paper, we report a clinical case Purpura Annularis Telangiectodes Majocchi following third-dose administration Pfizer-BioNTech COVID-19 vaccine. Almost 30 days after third dose, patient presented erythematous annular patches on lower limbs purpuric peripheral...
Background. Adipose tissue macrophages (ATMs) and mast cells (MCs) play a role in immune responses. More recently, their involvement tumor angiogenesis chronic inflammatory conditions patients with obesity has been discovered. Furthermore, higher BMI (Body Mass Index) value corresponds to state. In particular, gastric (GTO) is characterized by Macrophages, Mast Cells Positive Triptase (MCPT), neo-formed microvessels (MVD). Materials Methods. We collected samples from December 2021 2022. The...
Background Angiogenesis is an important pathway in tumour growth and progression. regulated by several classical factors, Vascular Endothelial Growth Factor being the most important. On other hand tryptase, a serine protease stored released from mast cells (MCs) granules has been identified as new non-classical angiogenetic factor. Tryptase agonist of proteinase-activated receptor-2 (PAR-2) G protein involved cellular proliferation angiogenesis. In this study, we have evaluated correlations...
e16502 Background: In the last years published studies demonstrated that mast cells (MCs) contain pro-angiogenic factors associated with tumoral angiogenesis. Tryptase is most abundant and potent substance contained in MCs secretory granules it can be released tumour microenvironment. Up to now few data have been on role of angiogenesis both pancreatic ductal adenocarcinoma cancer tissue (PDACT) adjacent normal (ANT). Methods: this study density positive C-Kit receptor (MCDP-C-KitR),...
According to scientific literature, cryoablation (CA) and electrochemotherapy (ECT) have been used for the treatment of small renal masses. However, no data published regarding combination these techniques as therapy primary kidney cancers. Therefore, we report case an old woman affected by localized cancer discuss potential therapeutic application CA combined with subsequent deep ECT in this setting.An 85 years-old-woman was evaluated because a cancer. Her background history included...
lating monocytes, which extravasate in response to various stimuli order differentiate into tissue-resident macrophages. [1]eir involvement maintaining normal tissue homeostasis and responding pathogens is well established, different phenotypes have been identified based on the means of activation, defined by microenvironment: macrophages 1 (M1) are known as "classically activated", while 2 (M2) "alternatively activated". [2]e former interferon-γ (IFN-γ), bacterial lipopoly-saccharide (LPS)...