М. А. Ефимова

ORCID: 0000-0001-8786-1310
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Research Areas
  • Viral gastroenteritis research and epidemiology
  • Animal Disease Management and Epidemiology
  • Rabies epidemiology and control
  • Bacillus and Francisella bacterial research
  • Vector-Borne Animal Diseases
  • Animal Virus Infections Studies
  • Virus-based gene therapy research
  • Yersinia bacterium, plague, ectoparasites research
  • Virology and Viral Diseases
  • Viral Infections and Immunology Research
  • Mycobacterium research and diagnosis
  • Poxvirus research and outbreaks
  • Viral Infectious Diseases and Gene Expression in Insects
  • Bacteriophages and microbial interactions
  • Vector-borne infectious diseases
  • Tuberculosis Research and Epidemiology
  • Socioeconomic and Demographic Analysis
  • Microbial infections and disease research
  • Hepatitis B Virus Studies
  • Animal Nutrition and Physiology
  • Viral Infections and Vectors
  • Rabbits: Nutrition, Reproduction, Health
  • Animal Nutrition and Health
  • Immunotoxicology and immune responses
  • Helminth infection and control

Kazan State Academy of Veterinary Medicine named after N.E. Bauman
2018-2025

New York Academy of Medicine
2022-2024

Kazan State Medical Academy
2020-2022

Saint Petersburg State Academy of Veterinary Medicine
2021

Russian Medical Academy of Continuous Professional Education
2020-2021

Kazan Scientific Center
2016-2021

State University of Management
2021

Kazan Federal University
2018-2020

Ministry of Health of the Russian Federation
2020

Despite the significant global economic damage caused by African swine fever (ASF) and ongoing developments in field of specific prevention tools development, safe effective vaccines are still missing. A critical factor hindering development ASF is lack sufficient data on pathogenesis virus, as well a deep understanding virus' evasion strategies from innate immune system. Of particular interest design candidate viral vectors, especially-adeno-associated virus (AAV), which widely used gene...

10.1155/vmi/9191117 article EN cc-by Veterinary Medicine International 2025-01-01

Porcine circovirus type 2 (PCV2) is one of the most significant pathogens in global pig industry. Due to fact that distinctive feature porcine circovirus-associated diseases (PCVAD) a chronic course, it necessary introduce effective serodiagnostics methods determine viral kinetics populations. The aim study was develop an indirect enzyme-linked immunosorbent assay (ELISA) based on recombinant capsid protein detect antibodies PCV2. At first stage, structure analyzed, which dominant regions...

10.36871/vet.zoo.bio.202504208 article EN Veterinariya Zootekhniya i Biotekhnologiya 2025-01-01

Adeno-associated virus serotype 2 (AAV2) represents a promising basis for developing virus-vector vaccine against African swine fever (ASF). This study aimed to create genetic constructs based on AAV2 deliver the immunodominant genes of ASF (ASFV) and evaluate their functionality in vitro. The efficiency specificity transgene expression, as well non-toxicity cells target animals, were evaluated. Bioinformatics analysis methods used identify ASFV. B646L, E183L, CP204L, CP530R identified...

10.14202/vetworld.2023.2425-2430 article EN cc-by Veterinary World 2023-12-01

Despite the fact that climate of North-East (NE) India is suitable for tick diversity, no systematic study has been done regarding prevalence ticks and tick-borne pathogens affecting small ruminants. A total 1053 goats belonging to different age groups, breeds, sex were examined from April 2019 March 2020. Blood smear examination PCR assays conducted detect in collected samples. The species recorded Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum, Haemaphysalis bispinosa....

10.1080/01647954.2022.2036232 article EN International Journal of Acarology 2022-02-16

Relevance. Prevention and control of ASF is significantly hampered by the lack available vaccines effective therapeutic measures. The virus capable interfering with various cellular signaling pathways, leading to immunomodulation, which makes development an vaccine extremely difficult. Given limitations known strategies for vaccines, search promising platforms safe drugs combat ongoing. basis design candidate choice immunogenic peptides that provide stable humoral immune responses...

10.32634/0869-8155-2023-368-3-40-45 article EN Agrarian science 2023-04-10

The main results of surveys the population Russian Federation on use information technologies and telecommunication networks, as well communication by organizations for period 2014-2016 have been described. analysis population’s personal computers including in terms gender, age, place residence has carried out. Particular attention paid to assessing regularity computer skills. characteristic using Internet was given. with dierent levels education considered. purposes Special issue security

10.26425/1816-4277-2018-9-90-94 article EN cc-by Vestnik Universiteta 2018-01-01

Coxiella burnetii and Borrelia burgdorferi sensu lato are intracellular bacteria of great zoonotic importance. To detect these two pathogensin ticks as well in blood samples, a nested PCR conventional was used. A total 525 were collected randomly from infected goats. Blood samples also tick-infested Both assessed for the presence organisms using Polymerase chain reaction (PCR) assays targeting fragment 16S rRNA, superoxide dismutase (SOD) C. ospA gene B. s.l. Sequence analysis amplified used...

10.1080/01647954.2020.1805000 article EN International Journal of Acarology 2020-08-17

The present study reports the prevalence of ecto- and endo-parasites in small wild ruminants from various NE region India. A total 565 captivity were examined between April 2018 to March 2019 without causing harm them. Faecal samples microscopically for detection different Gastrointestinal (GI) parasites. Animals also inspected visually any ectoparasitic infestation skin scrapping examination was performed suspected lesion mite infestation. Overall seven species endoparasites including three...

10.1080/09291016.2019.1628401 article EN Biological Rhythm Research 2019-11-22

Background and Aim: Several reports described the detection of specific caprine arthritis-encephalitis virus (CAEV) antibodies in Russian goat populations, which indicates circulation CAEV farms. The aim this study was to use a multi-target approach testing with both serological tests an in-house real-time (RT) molecular test investigate prevalence goats from three hobbyist farms Republic Tatarstan, Russia. Materials Methods: We applied enzyme-linked immunosorbent assay (ELISA) RT polymerase...

10.14202/vetworld.2021.1718-1726 article EN cc-by Veterinary World 2021-07-01

Porcine circovirus-associated diseases (PCVDs) are among the most significant challenges for pig farming in developed countries. circovirus type 2 (PCV-2) is considered main etiological agent of postweaning multisystemic wasting syndrome piglets. Mass PCVD occurrence has been reported regions world, that results serious economic consequences. Optimal prevention known to be achieved through a set veterinary and sanitary measures combination with vaccination. High evolutionary virus...

10.29326/2304-196x-2024-13-1-57-63 article EN cc-by Veterinary Science Today 2024-03-15

African swine fever (ASF) is a highly contagious viral disease of the Suidae family representatives, mortality rate in primary foci which reaches 100 %. To date, no specific means preventing ASF have been developed. Despite fact that researchers proposed various methods for creating candidate vaccines against ASF, issue developing alternative antigenic variants with low reactogenicity and high immunogenicity still relevant. It known production recombinant adeno-associated virus, potential...

10.52419/issn2072-2419.2024.1.22 article EN cc-by International Journal of Veterinary Medicine 2024-04-02

Relevance. African swine fever (ASF) is a viral hemorrhagic disease with exceptionally high mortality in members of the family Suidae , serious economic consequences associated production losses, trade restrictions and eradication programs. To date, no effective commercial vaccine against ASF has been developed. Of particular interest design candidate vaccines are vectors, adenoassociated virus 2nd serotype (AAV2), which successfully proven itself as gene therapy agent. We previously...

10.32634/0869-8155-2024-383-6-39-43 article EN Agrarian science 2024-06-13

Currently, live attenuated vaccines are used in the Russian Federation for specific prevention of classical swine fever (CSF), but this strategy contradicts rules importing animal products and carries risks recombination with field strains. These factors exacerbate need further development candidate recombinant similar efficacy safety. The aim presented work was to construct a prokaryotic expression system marked glycoprotein E2 CSF virus evaluate its immunochemical properties. As result...

10.52419/issn2072-2419.2024.2.49 article EN International Journal of Veterinary Medicine 2024-06-28

The prevalence of endoparasitic infections birds in different zoological gardens North-Eastern region India was investigated from February 2018 to January 2019. Coprological examination included 1,275 faecal samples 10 species captive six zoo gardens. blood parasites also carried out by examining a total 175 samples. Faecal were examined flotation method using saturated salt solution and conventional sedimentation method. after staining with Giemsa stain. overall helminths 29.25%. We have...

10.1080/09291016.2019.1608725 article EN Biological Rhythm Research 2019-05-01
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