A5015710216- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Erythrocyte Function and Pathophysiology
- CRISPR and Genetic Engineering
- Lipid Membrane Structure and Behavior
- Nanopore and Nanochannel Transport Studies
- Crystallography and molecular interactions
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Inhalation and Respiratory Drug Delivery
- Graphene and Nanomaterials Applications
- Angiogenesis and VEGF in Cancer
- Plant nutrient uptake and metabolism
- Adenosine and Purinergic Signaling
- Cerebrospinal fluid and hydrocephalus
- Genetic Syndromes and Imprinting
- Immune cells in cancer
- Enzyme function and inhibition
- melanin and skin pigmentation
- Enzyme Production and Characterization
University of California, San Diego
2010-2025
Zhejiang A & F University
2018-2024
Bridge University
2023
Jiyang College of Zhejiang A&F University
2018
Duke-NUS Medical School
2015
Institute of Molecular and Cell Biology
2015
Beijing Forestry University
2008-2014
University of California, Irvine
2012-2013
Institute of Geochemistry
2013
Chinese Academy of Sciences
2013
Abstract Amidst the rising prevalence of respiratory diseases, importance effective lung treatment modalities is more critical than ever. However, current drug delivery systems face significant limitations that impede their efficacy and therapeutic outcome. Biohybrid microrobots have shown considerable promise for active in vivo delivery, especially pulmonary applications via intratracheal routes. invasive nature administration poses barriers to its clinical translation. Herein, we report on...
Toll-like receptors (TLRs) trigger intestinal inflammation when the epithelial barrier is breached by physical trauma or pathogenic microbes. Although it has been shown that TLR-mediated signals are ultimately protective in models of acute [such as dextran sulfate sodium (DSS)-induced colitis], less clear which cells mediate protection. Here we demonstrate TLR signaling nonhematopoietic compartment confers protection DSS-induced colitis. Epithelial MyD88/Trif-deficient mice express...
The hypothalamus is the central regulator of systemic energy homeostasis, and its dysfunction can result in extreme body weight alterations. Insights into complex cellular physiology this region are critical to understanding obesity pathogenesis; however, human hypothalamic cells largely inaccessible for direct study. Here, we developed a protocol efficient generation neurons from embryonic stem (ESCs) induced pluripotent (iPSCs) obtained patients with monogenetic forms obesity. Combined...
Over 40 missense mutations in the human SCN1A sodium channel gene are linked to an epilepsy syndrome termed genetic with febrile seizures plus (GEFS+). Inheritance of GEFS+ is dominant, but underlying cellular mechanisms remain poorly understood. Here we report that knock-in a mutation (K1270T) into Drosophila gene, para , causes semidominant temperature-induced seizure phenotype. Electrophysiological studies GABAergic interneurons brains adult flies reveal novel mechanism heat-induced...
Deficiencies of subunits the transcriptional regulatory complex Mediator generally result in embryonic lethality, precluding study its physiological function. Here we describe a missense mutation Med30 causing progressive cardiomyopathy homozygous mice that, although viable during lactation, show precipitous lethality 2–3 wk after weaning. Expression profiling reveals pleiotropic changes transcription cardiac genes required for oxidative phosphorylation and mitochondrial integrity. Weaning...
Abstract Nanodiscs are a compelling nanomedicine platform due to their ultrasmall size and distinct disc shape. Current nanodisc formulations made primarily with synthetic lipid bilayers proteins. Here, we report cellular human red blood cell (RBC) membrane (denoted “RBC‐ND”) show its effective neutralization against bacterial toxins. In vitro, RBC‐ND neutralizes the hemolytic activity cytotoxicity caused by purified α‐toxin or complex whole secreted proteins (wSP) from methicillin‐resistant...
Glucaric acid (GA) is a value-added chemical and can be used to manufacture food additives, anticancer drugs, polymers. The non-genetic cell-to-cell variations in GA biosynthesis are naturally inherent, indicating the presence of both high- low-performance cells culture. Low-performance lead nutrient waste inefficient production. Furthermore,
Systemic administration of Ad5-based recombinant adenovirus leads to preferential transduction the liver. Using this property, we have assessed potential venous viral injection deliver a antiangiogenic treat cancer dissemination and improve survival. The results demonstrate that AdmATF, which encodes secretable mouse ATF (amino-terminal fragment urokinase) known inhibit angiogenesis, suppressed angiogenesis induced by colon metastasis growth in mice liver improved Nude were injected...
Robust strategies for developing patient-specific, human, induced pluripotent stem cell (iPSC)-based therapies of the brain require an ability to derive large numbers highly defined neural cells. Recent progress in iPSC culture techniques includes partial-to-complete elimination feeder layers, use media, and single-cell passaging. However, these still embryoid body formation or coculture differentiation into cells (NSCs). In addition, none published methodologies has employed all advances a...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCondensation of Plasmids Enhanced by Z-DNA Conformation d(CG)n InsertsChenglie Ma, Lei Sun, and Victor A. BloomfieldCite this: Biochemistry 1995, 34, 11, 3521–3528Publication Date (Print):March 21, 1995Publication History Published online1 May 2002Published inissue 21 March 1995https://pubs.acs.org/doi/10.1021/bi00011a005https://doi.org/10.1021/bi00011a005research-articleACS PublicationsRequest reuse permissionsArticle...
With the increasing recognition of its role in trait and disease development, it is crucial to account for genetic imprinting illustrate architecture complex traits. Genetic mapping can be innovated test estimate effects a segregating population derived from experimental crosses. Here, we describe assess design detection natural plant populations. This sample maternal plants at random collect open-pollinated (OP) seeds randomly each germinate them into seedlings. A two-stage hierarchical...
Abstract Aptamers are single‐stranded oligonucleotides that fold into defined architectures for specific target binding. In this study, aptamers selected specifically bind to small‐molecule neurotoxins and encapsulate them cell membrane‐coated nanoparticles (referred as ‘cellular nanoparticles’ or ‘CNPs’) effective neutralization of neurotoxins. Specifically, six different saxitoxin (STX) tetrodotoxin (TTX) metal–organic framework cores, which then coated with neuronal membrane. The...
Abstract In the current information technology, basic feature of dynamic image recognition is to digitize biological different individuals. Compare features that can be identified, and then realize function. This article first investigates status clothing sales platform management method, introduces main situation AI learning, analyzes work flow platform, studies needs, focuses on whether this technology improve The efficiency company launched an in-depth discussion. Secondly, it some...
Abstract Nanodiscs are a compelling nanomedicine platform due to their ultrasmall size and distinct disc shape. Current nanodisc formulations made primarily with synthetic lipid bilayers proteins. Here, we report cellular human red blood cell (RBC) membrane (denoted “RBC‐ND”) show its effective neutralization against bacterial toxins. In vitro, RBC‐ND neutralizes the hemolytic activity cytotoxicity caused by purified α‐toxin or complex whole secreted proteins (wSP) from methicillin‐resistant...