To investigate the immunohistochemical expressions of p53, ki67, CK20 in superficial papillary urothelial neoplasms bladder and correlate them with histological grade, tumor progression recurrence.We selected samples 43 patients transitional cell carcinoma bladder. They were divided into two groups, one called Recurrent (R), 18 individuals, other Non-Recurrent (NR), 25. Multi-sampling blocks prepared. The technique employed was immunoperoxidase, antibodies were: p53: Novocastra (clone DO7)...

To analyze the efficiency of labeling impalpable breast lesions with inert charcoal suspension; to evaluate morphological alterations associated its use and determine whether hampers diagnostic interpretation pathologist.Was evaluated a total 135 cases previously labeled suspension. Histological H&E stained slides containing pigments were analyzed using optical microscopy, by which both quantitative qualitative evaluations regards inflammatory response interference in diagnosis performed....

OBJETIVO: Avaliar a presença de foco criptas aberrantes (FCA) em mucosa macroscopicamente normal, localizada na periferia um câncer colorretal (CCR) e correlacionar progressão tumoral destes FCA para o CCR, por meio da expressão β-catenina Ki-67. MÉTODOS: Utilizou-se 21 espécimes cirúrgicos contendo adenocarcinoma junção retossigmóide. Foram coletadas amostras localizadas 1 5 cm proximal distal ao tumor, quando possível, bem como fragmento neoplasia. Os foram selecionados. Subseqüentemente...

ABSTRACT Background: Colorectal cancer (CRC) has high mortality rates worldwide. In Brazil, it is the second most common in both sexes. Delay detecting premalignant lesions contributes to increased morbidity and mortality. this scenario, Piranhas project was created track CRC a low-income population hinterland of Alagoas. Objective: The study aimed establish main strategies verify feasibility implementing tracking program demonstrate results obtained Prevention Campaign Piranhas/AL. Methods:...

Expression of CD133 and ABCB5 is associated with tumor aggressiveness, but evidence in papillary thyroid cancer (PTC) lacking. We correlated expression pathological characteristics factors worse prognosis PTC. Samples 119 PTCs 40 controls (goiters) were distributed 8 tissue microarray blocks evaluated immunohistochemistry using anti-CD133 anti-ABCB5 antibodies. The each marker alone combined was analyzed against (19 tumors, 16.0%) more frequent patients versus without lymph node metastases...

Pituitary gland extirpation has been performed by many investigators (Biedl, Aschner). In the course of an investigation on effect pituitary upon body temperature in pigeon we were often compelled to ablate gland. The cranial method (dishing, Kreidl) was first tried vain, then palatine (Caselli, Gaglio) proved also fruitless. We thus driven devise a new which operation carried out through orbital cavity. eye-ball one side enucleated and intervening bone removed give access mid-brain cavity...

Objective: To study the potential chemopreventive effects of polyunsaturated fatty acids omega-3 in Swiss mice submitted to oral and oesophageal carcinogenesis induction by 4-nitroquinoline-1-oxide (4-NQO). Study design:The animals underwent with 50 µg/mL 4-NQO for eight weeks.The were divided into groups: Group I-4-NQO without chemoprevention, II-chemoprevention addition 5% fish oil (FO) their diet after induction, III-chemoprevention FO during induction. Results:The incidence invasive...

Abstract In dogs under ether or chloroform, stimulation of sensory nerves (saphenous, tibial, peroneal, sciatic, ulnar, and median) causes usually increased respiratory movements when narcosis is not profound curare employed. These produce a fall blood‐pressure, they are very violent, one cannot obtain any pressor reflex even with strong stimulation. When much prevented by deep brain compression, blood‐pressure due to this cause does occur. Mechanical interference the circulation as result...

Ileal inflammatory fibroid polyp is a rare non-neoplastic lesion of the gastrointestinal tract. Intussusception caused by an polyps uncommon. The authors report case 75 year-old female patient presenting with ileal obstruction due to intussusception polypoid lesion. underwent surgical treatment and histopathology confirmed diagnosis.

O tumor desmoplásico de pequenas células redondas (TDPCR) é uma neoplasia rara, que foi recentemente relatada por Gerald et al. Foram descritos aproximadamente 101 casos na literatura, tendo localização predominantemente intra-abdominal e acometendo com maior freqüência crianças adultos jovens. Os autores relatam um caso TDPCR em adulto jovem 24 anos. Este paciente apresentava quadro inespecífico náuseas, vômitos, além único episódio hematêmese. Ao exame físico constatou-se massa sólida...

Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease that affects the pulmonary vasculature, leading to increased afterload and eventually right ventricular (RV) remodelling failure. Bilateral sympathectomy (BS) has shown promising results in dampening cardiac dysfunction several heart failure models. In present study, we investigated whether BS reduces mitigates RV failure.PAH was induced male Wistar rats by intraperitoneal injection of monocrotaline. Rats were divided into 3...

Abstract Langerhans’ cell histiocytosis is a rare disease characterized by proliferation of Langerhans cells in the body. It affects mainly males, predominantly childhood. Ulcerated plaques are one cutaneous forms presentation. Diagnostic confirmation done through immunohistochemistry. As therapeutic options, topical corticosteroids and chemotherapy good choices. The case reported male patient, aged 14, with perianal ulceration. He consulted coloproctologist, who performed biopsy region...

Background: Cutaneous adnexal tumors are rare neoplasms that arise from the skin's structures.Differential diagnosis includes benign and malignant entities.Case Report: A 62-year-old woman presented with a persistent nodular ulcerated lesion on scalp.An incisional biopsy revealed cutaneous tumor, which was excised.Histopathology showed epithelial neoplasia positive immunohistochemistry for pan-cytokeratin AE1/AE3, gata-3, estrogen receptors.It suggested it could be DEC, patient remained...

Os pseudotumores fibrosos são lesões incomuns que ocorrem geralmente em resposta a cirurgia, trauma, infecção ou inflamação. Relatamos um caso de paciente com 25 anos idade apresentou massa escrotal indolor. Realizou-se orquiectomia radical. O diagnóstico anatomopatológico foi pseudotumor fibroso do cordão espermático.

Osteosarcoma most frequently affects long bones, particularly around the knee, and is therefore rare in forearm. We report case of a 67-year-old woman presenting with progressive lesion distal radius. A pathological diagnosis osteoblastic osteosarcoma was suspected confirmed by needle biopsy. There had been two other cases same family. The patient treated neoadjuvant chemotherapy followed amputation arm below elbow.

As glândulas sebáceas ectópicas são achados muito infrequentes no trato genital feminino. Descrevemos um caso que ocorreu em paciente de 42 anos idade, submetida à histerectomia total, devido leiomiomatose e ao prolapso uterino.

Os autores relatam o caso de paciente do sexo feminino, 52 anos, com queixas hematúria macroscópica e dor pélvica. Foi realizado exame ultrassonográfico, que mostrou massa expansiva em assoalho vesical. A cistoscopia confirmou a presença dessa lesão, sendo realizada biópsia. O histológico revelou neoplasia pequenas células. análise imuno-histoquímica foi necessária para elucidação diagnóstica. referido demonstrou positividade os marcadores EWS-FLI1, CD99 S-100. diagnóstico tumor...

Introdução: Os carcinossarcomas uterinos são neoplasias infrequentes, correspondendo a apenas 3-9% de todas as ginecológicas, representam 48% todos os sarcomas, e possuem incidência 8,2 por 1 milhão mullheres/ano. As principais manifestações clínicas o sangramento vaginal anormal em idade pós-menopausa dor abdominal. Caracterizam-se morfologicamente elementos epiteliais estromais. Podem eventualmente invadir estruturas adjacentes, inclusive bexiga urinária. Relato do caso: Apresentamos um...