A5019145772- Neurotransmitter Receptor Influence on Behavior
- Forensic Toxicology and Drug Analysis
- Psychedelics and Drug Studies
- Nicotinic Acetylcholine Receptors Study
- Alcohol Consumption and Health Effects
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Zebrafish Biomedical Research Applications
- Nerve injury and regeneration
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Phenothiazines and Benzothiazines Synthesis and Activities
- Genetics and Physical Performance
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Prenatal Substance Exposure Effects
- Chemical synthesis and alkaloids
- Immunotoxicology and immune responses
- Biochemical Acid Research Studies
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Birth, Development, and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Peroxisome Proliferator-Activated Receptors
Universitat de Barcelona
2016-2025
Institut de Biomedicina de la Universitat de Barcelona
2022-2024
Institute for Research in Biomedicine
2023
American University
2018-2019
Here, we have compared the neurochemical profile of three new cathinones, butylone, mephedrone and methylone, in terms their potential to inhibit plasmalemmal vesicular monoamine transporters. Their interaction with 5-HT dopamine receptors psychostimulant effect was also studied.Locomotor activity recorded mice following different doses cathinones. Monoamine uptake assays were performed purified rat synaptosomes. Radioligand-binding carried out assess affinity these compounds for...
Mephedrone is a drug of abuse marketed as 'bath salts". There are discrepancies concerning its long-term effects. We have investigated the neurotoxicity mephedrone in mice following different exposition schedules. Schedule 1: four doses 50 mg/kg. 2: 25 3: three daily mg/kg, for two consecutive days. All schedules induced, some animals, an aggressive behavior and hyperthermia well decrease weight gain. (schedule 1) induced dopaminergic serotoninergic that persisted 7 days after exposition. At...
3,4-methylenedioxypyrovalerone or MDPV is a synthetic cathinone with psychostimulant properties more potent than cocaine. We quantified this drug in the striatum after subcutaneous administration to rats. reached brain around 5 min its and peaked at 20–25 later. The elimination half-life (61 min) correlates decrease effect 60 min. Around 11% of administered dose and, considering homogeneous distribution, we determined that 86% plasma distributed brain. induced dose-dependent increase...
The emergence of new synthetic cathinones continues to be a matter public health concern. In fact, they are quickly replaced by structurally related alternatives. main goal the present study was characterize pharmacological profile, psychostimulant and rewarding properties novel (pentedrone, N-ethyl-pentedrone, α-PVP, N,N-diethyl-pentedrone α-PpVP) which only differs in their amino terminal substitution. Rat synaptosomes were used for [3H]dopamine uptake experiments. HEK293 transfected cells...
Abstract Recent studies have sparked renewed interest in the therapeutic potential of psychedelics for treating depression and other mental health conditions. Simultaneously, novel psychoactive substances (NPS) phenomenon, with a huge number NPS emerging constantly, has changed remarkably illicit drug market, being their scientific evaluation an urgent need. Thus, this study aims to elucidate impact amino-terminal modifications 5-MeO-DMT molecule on its interactions serotonin receptors...
Several new synthetic cathinones, which mimic the effect of classical psychostimulants such as cocaine or MDMA, have appeared in global illicit drug market last decades. In fact, is continually evolving by constantly adding small modifications to common chemical structure cathinones. Thus, aim this study was investigate vitro and vivo structure-activity relationship (SAR) six novel cathinones currently popular recreational drugs, pentedrone, pentylone, N-ethyl-pentedrone (NEPD),...
Cocaine, methamphetamine, ectasy (3,4-methylenedioxy amphetamine (MDMA)) and ketamine are among the most consumed drugs worldwide causing cognitive, oxidative stress cardiovascular problems in humans. Residue levels of these their transformation products may still enter aquatic environment, where concentrations up to hundreds ng/L have been measured. In present work we tested hypothesis that psychotropic effects mode action D. magna responses equivalent those reported humans other vertebrate...
Changes in the molecular structure of synthetic cathinones has led to an increase number novel emerging drugs illicit drug market at unprecedented rate. Unfortunately, little is known about neuropsychopharmacology recently emerged halogen-substituted α-PVP derivatives. Thus, aim this study was investigate role para- and meta-halogen (F-, Cl-, Br-) substitutions on vitro, silico, vivo effects α-pyrrolidinopentiophenone (α-PVP) HEK293 cells expressing human dopamine or serotonin transporter...
Methylone is a cathinone derivative that has recently emerged as designer drug of abuse in Europe and the USA. Studies on acute long-term neurotoxicity cathinones are starting to be conducted. We investigated neurochemical/enzymatic changes indicative after methylone administration (4 × 20 mg/kg, subcutaneously, per day with 3 h intervals) adolescent rats, model human recreational use. In addition, we studied effect spatial learning ad memory using Morris water maze paradigm. Our experiments...
Synthetic cathinones are β-keto amphetamine derivatives whose appearance has increased dramatically in the past decades. N-Ethyl substituted have been proven to potently inhibit dopamine (DA) uptake and induce psychostimulant rewarding effects mice. However, little is known about influence of alpha-carbon side-chain length N-ethyl on their pharmacological toxicological effects. Thus, aim this study was synthesize investigate vitro vivo five cathinones: N-ethyl-cathinone (NEC),...
Background and Purpose 3,4‐Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone with powerful psychostimulant effects. It selectively inhibits the dopamine transporter (DAT) 10–50‐fold more potent as DAT blocker than cocaine, suggesting high abuse liability. The main objective of present study was to assess consequences an early (adolescence) MDPV exposure on psychostimulant, rewarding reinforcing effects induced by cocaine in adult mice. Experimental Approach Twenty‐one days after...
Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone which has recently emerged as designer drug of abuse. The objective this study was to investigate the locomotor sensitization induced by MDPV in adolescent mice, and associated neuroplastic changes nucleus accumbens striatum through deltaFosB CREB expression. Behavioural testing consisted three phases: Phase I: conditioning regimen with (0.3 mg/kg/day for five days) or saline; II: resting (11 days); III: challenged mg/kg), cocaine...
Hyperthermia is a common confounding factor for assessing the neurotoxic effects of methamphetamine (METH) in mammalian models. The development new models neurotoxicity using vertebrate poikilothermic animals should allow to overcome this problem. aim present study was develop zebrafish model by binge-like exposure. After an initial testing at 20 and 40 mg/L 48 h, later METH concentration selected developing on brain monoaminergic profile, locomotor, anxiety-like social behaviors as well...