A5025080183- Zebrafish Biomedical Research Applications
- Neurotransmitter Receptor Influence on Behavior
- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Reproductive biology and impacts on aquatic species
- Fish Ecology and Management Studies
- Receptor Mechanisms and Signaling
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Gastrointestinal motility and disorders
- Fish Biology and Ecology Studies
- Neuroendocrine regulation and behavior
- Forensic Toxicology and Drug Analysis
- Physiological and biochemical adaptations
- Pesticide Exposure and Toxicity
- Pesticide Residue Analysis and Safety
- European Political History Analysis
- Pesticide and Herbicide Environmental Studies
- Cholinesterase and Neurodegenerative Diseases
- Aquatic Ecosystems and Phytoplankton Dynamics
- Historical Gender and Feminism Studies
- Photoreceptor and optogenetics research
- Gender Roles and Identity Studies
- Effects and risks of endocrine disrupting chemicals
- SARS-CoV-2 and COVID-19 Research
Universitat Ramon Llull
2020-2024
Universidade Estadual Paulista (Unesp)
2020-2024
Institut Químic de Sarrià
2020-2024
Ação Educativa
2022
Institute of Environmental Assessment and Water Research
2022
Núcleo de Pesquisas Aplicadas (Brazil)
2021
Glyphosate is the active ingredient of some most highly produced and used herbicides worldwide. The intensive applications glyphosate-based its half-life in water lead to presence many aquatic ecosystems. Whereas recent studies have reported neurotoxic effects glyphosate including autism-related effects, them extremely high (mg/L g/L) concentrations, so it still unclear if chronic, low environmentally relevant concentrations this compound (ng/L μg/L) can induce neurotoxicity. In study we...
Fenitrothion is an organophosphorus insecticide usually found in aquatic ecosystems at concentrations the range of low ng/L. In this manuscript we show that 24 h exposure to environmental fenitrothion, from ng/L μg/L, altered basal locomotor activity, visual-motor response and acoustic/vibrational escape zebrafish larvae. Furthermore, fenitrothion expression gap43a, gfap, atp2b1a, mbp exhibited a significant non-monotonic concentration-response relationship. Once determined were neurotoxic...
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-quinone) is a degradation product of 6PPD, an antioxidant widely used in rubber tires. 6PPD-quinone enters aquatic ecosystems through urban stormwater runoff and has been identified as the chemical behind mortality syndrome coho salmon. However, available data suggest that acute effects are restricted to few salmonid species environmental levels this should be safe for most fish. In study, larvae "tolerant" fish species, Danio...
The insecticide carbaryl is commonly found in indirectly exposed freshwater ecosystems at low concentrations considered safe for fish communities. In this study, we showed that after only 24 h of exposure to environmental (0.066–660 ng/L), zebrafish larvae exhibit impairments essential behaviours. Interestingly, the observed behavioural effects induced by were acetylcholinesterase-independent. To elucidate molecular initiating event resulted effects, silico predictions followed vitro...
Cocaine, methamphetamine, ectasy (3,4-methylenedioxy amphetamine (MDMA)) and ketamine are among the most consumed drugs worldwide causing cognitive, oxidative stress cardiovascular problems in humans. Residue levels of these their transformation products may still enter aquatic environment, where concentrations up to hundreds ng/L have been measured. In present work we tested hypothesis that psychotropic effects mode action D. magna responses equivalent those reported humans other vertebrate...
This study examines the effects of acute pharmacological modulation serotonergic system over zebrafish larvae’s cognitive, basic, and defense locomotor behaviors, using a medium to high throughput screening assay. Furthermore, relationship between behavior, enzyme activity related neurotransmitter metabolism, levels, gene expression was also determined. Modulation larvae accomplished by 24 h exposure single opposite pharmacodynamics co-exposure three model psychopharmaceuticals with...
Animal behavioural responses are increasingly being used in environmental risk assessment. Nevertheless, still hampered by a lack of standardisation. Phototactic behaviour zooplankton and particular Daphnia has often been associated to vertical migration but there is also 'shore-avoidance' horizontal behaviour: uses shades along the shore swim either or away from predators. Previously, we develop oriented hardware able reproduce phototactic fish induced depth selection magna, its modulation...
Autism spectrum disorder (ASD) is a neurodevelopmental characterized by impairments in social interaction and communication, anxiety, hyperactivity, restricted interest for specific subjects. In addition to the genetic factors, multiple environmental factors have been related development of ASD. Animal models can serve as crucial tools understanding complexity ASD identifying potential therapeutic strategies. this study, chemical model has developed zebrafish exposing embryos valproic acid...
Fluoxetine is widely prescribed for the treatment of depressive states, acting at level central nervous system, consequently affecting non-target organisms. This study aimed to investigate influence environmentally relevant fluoxetine concentrations (1-1000 ng/L) on Danio rerio development, assessing both embryotoxicity and behavior, antioxidant defense, gene expression neurotransmitter levels larval stage. Exposure during early development was found be able accelerate embryo hatching in...
Glyphosate, a globally prevalent herbicide known for its selective inhibition of the shikimate pathway in plants, is now implicated physiological effects on humans and animals, probably due to impacts their gut microbiomes which possess pathway. In this study, we investigate environmentally relevant concentrations glyphosate microbiota, neurotransmitter levels, anxiety zebrafish. Our findings demonstrate that exposure leads dysbiosis zebrafish gut, alterations central peripheral serotonin...
Individuals differ in their preference for alcohol and propensity to develop alcoholism, where the behavioral profile, such as bold-shy axis, plays an important role a difference. However, literature is limited conflicting on causes consequences of this relationship. Translational studies using animal models, zebrafish, can help identify traits that predispose individuals drink compulsively. Here, was investigated two distinct zebrafish: shy bold. For purpose, fish were separated into bold...
The number of people suffering from mental health problems is rising, with anxiety and depression now the most commonly diagnosed psychiatric conditions. Selective serotonin reuptake inhibitors (SSRIs) are one prescribed pharmaceuticals to treat these conditions, which has led their common detection in many aquatic ecosystems. As monoaminergic system shows a high degree structural conservation across diverse animal phyla, reasonable assumption that environmental levels SSRIs surface water...
Nile tilapia farmers must deal with production challenges, such as increased aggressiveness and high stress levels, which potentially diminishes fish welfare. Tryptophan supplementation is a strategy to cope problems. However, data scarce on how tryptophan affects the of this species other aspects need be understood it influences in fish. In study, we investigate 1× (0.32%), 4× (1.28%) 8× (2.56%) supplemented diet tilapia. Aggressiveness was assessed after short-term exposure (7 days) while...
This study assessed the effects of monoamine oxidase (MAO) inhibitor deprenyl in Daphnia magna locomotor activity. The mechanisms action were also determined by studying relationship between behaviour, MAO activity and neurotransmitter levels. Modulation D. system was accomplished 24 h exposure to two model psychotropic pharmaceuticals with antagonistic agonistic serotonin signalling properties: 10 mg/L 4-chloro-DL-phenylalanine (PCPA) 1 deprenyl, respectively. Contrasting behavioural...
Hyperthermia is a common confounding factor for assessing the neurotoxic effects of methamphetamine (METH) in mammalian models. The development new models neurotoxicity using vertebrate poikilothermic animals should allow to overcome this problem. aim present study was develop zebrafish model by binge-like exposure. After an initial testing at 20 and 40 mg/L 48 h, later METH concentration selected developing on brain monoaminergic profile, locomotor, anxiety-like social behaviors as well...
Abstract Background and Purpose New psychoactive substances such as N ‐ethylpentylone (NEP) are continuously emerging in the illicit drug market, knowledge of their effects risks, which may vary between sexes, is scarce. Our present study compares some key NEP male female mice. Experimental Approach Psychostimulant, rewarding reinforcing were investigated by tracking locomotor activity, conditioned place preference (CPP) paradigm through a self‐administration (SA) procedure, respectively,...
Zebrafish embryos and larvae are vertebrate models increasingly used in translational neuroscience research. Behavioral impairment induced by the exposure to neuroactive or neurotoxic compounds is commonly linked changes modulatory neurotransmitters brain. Although different analytical methods for determining monoaminergic neurochemicals zebrafish have been developed, these only on whole larvae, as dissection of brain hundreds not feasible. This raises a key question: Are profile predictive...
N-ethyl-pentedrone (NEPD, 2-(ethylamino)-1-phenyl-1-pentanone) is one of the latest synthetic cathinone derivatives that emerged into illicit drug market. This has psychostimulant properties and been related with several intoxications even fatalities. However, information about consequences its acute repeated consumption lacking. Thus, aim our study was to investigate behavioral effects after both NEPD exposure as well neurochemical changes. Male OF1 mice were treated an dose (1, 3 or 10...
N-ethyl-pentylone (NEP), also known as 'ephylone' and N-ethylnorpentylone, has been identified one of the most recent novel psychostimulants to emerge into illicit drug market it associated with some intoxications even fatalities. However, little is about consequences its repeated consumption well role monoaminergic system in such consequences. Thus, aim our study was investigate neurochemical profile behavioural effects after both acute NEP exposure. Male OF1 mice were acutely (1, 3, 10...