A5034755954- Trypanosoma species research and implications
- SARS-CoV-2 and COVID-19 Research
- Adipose Tissue and Metabolism
- Research on Leishmaniasis Studies
- Exercise and Physiological Responses
- COVID-19 Clinical Research Studies
- Birth, Development, and Health
- Digital Imaging for Blood Diseases
- Aquaculture Nutrition and Growth
- Artificial Intelligence in Healthcare
- Cardiovascular and exercise physiology
- Synthesis and Biological Evaluation
- Ginseng Biological Effects and Applications
- Diabetes and associated disorders
- Macrophage Migration Inhibitory Factor
- Sirtuins and Resveratrol in Medicine
- Parasitic Infections and Diagnostics
- Steroid Chemistry and Biochemistry
- Proteoglycans and glycosaminoglycans research
- Renal function and acid-base balance
- Pharmacological Effects of Natural Compounds
- Zebrafish Biomedical Research Applications
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
Universidade Federal de Santa Maria
2021-2024
Keck Hospital of USC
2024
Fundação Oswaldo Cruz
2022
Texas Tech University
2021
Universidade Federal de Minas Gerais
2020
The University of Texas at El Paso
2015
Université Claude Bernard Lyon 1
2012
Universidad de León
2001-2002
Universidad de Salamanca
1999
Sirtuin 1 (SIRT1), a NAD+-dependent protein deacetylase, has emerged as main determinant of whole body homeostasis in mammals by regulating large spectrum transcriptional regulators metabolically relevant tissue such liver, adipose and skeletal muscle. Sterol regulatory element binding (SREBP)-1c is transcription factor that controls the expression genes related to fatty acid triglyceride synthesis tissues with high lipid rates liver. Previous studies indicate SIRT1 can regulate function...
Regulation of inflammation is a critical process for maintaining physiological homeostasis. The λ-carrageenan (λ-CGN) mucopolysaccharide extracted from the cell wall red algae (Chondrus crispus) capable inducing acute intestinal inflammation, which translated into production phase reactants secreted blood circulation. However, associated mechanisms in vertebrates are not well understood. Here, we investigated crucial factors behind inflammatory milieu λ-CGN-mediated administered at 0, 1.75,...
The purpose of this study was to evaluate DNA vaccination in cysticercosis prevention by using a Taenia crassiceps cDNA recombinant antigen (KETc7) that has been reported as protective against murine cysticercosis. KETc7 cloned into the pcDNA3 plasmid alone or with betaglycan signal peptide sequence (pTc-7 and pTc-sp7, respectively). Positive expression pTc-sp7 product confirmed transfection C33 cells immunofluorescence sera mice infected T. crassiceps. Immunization 3 injections at higher...
Summary Establishing new experimental animal models to assess the safety and immune response antigen used in development of COVID-19 vaccine is an imperative issue. Based on advantages using zebrafish as a model research, herein we suggest doing this test putative candidates study against virus. We produced recombinant N-terminal fraction Spike SARS-CoV-2 protein injected it into adult female zebrafish. The specimens generated humoral immunity passed antibodies eggs. However, they presented...
Aims: In order to assess the possible participation of nitric oxide (NO) in renal function during compensated hepatic cirrhosis, we studied function, plasma and urinary levels cGMP concentration nitrates nitrites, as markers NO synthesis blood urine, 10 patients with Child A cirrhosis compared control subjects, both under basal conditions stimulation (amino acid-induced glomerular hyperfiltration). Methods: To study filtration rate (GFR), effective flow (ERPF), functional reserve (RFR),...
Diabetic ketoacidosis develops when insulin is insuffcient to clear blood sugar into cells for energy, then the liver breaks down fat fuel with production of ketoacids. Lower pH activates proximal tubule PEPCK expression replenish bicarbonate and excrete acid via NHE3 as ammonia, known as, “ammoniagenesis.” Baseline female (F) rodents exhibit greater ammoniagenesis less activity than males (M). We examined in male (M) ZSF1 rats, a model obesity diabetic kidney disease. rats are born lean (L)...
Leishmania parasites are trypanosomatid protozoans that cause leishmaniasis affecting millions of people worldwide. Sterols important components the plasma and organellar membranes. They also serve as precursors for synthesis signaling molecules. Unlike animals, does not synthesize cholesterol but makes ergostane-based sterols instead. C-14-demethylase is a key enzyme involved in biosynthesis an drug target. In parasites, inactivation leads to multiple defects, including increased membrane...
Leishmania species are parasitic protozoans which cause leishmaniasis affecting millions of people worldwide. Sterols important components plasma and organellar membranes serve as precursors for the synthesis signaling molecules. In contrast to animals, do not produce cholesterol but instead synthesize ergostane-based sterols. C14-demethylase is a key enzyme involved in biosynthesis sterols parasites an drug target. Its inactivation leads multiple defects including increased membrane...