A5038967983- Laser Applications in Dentistry and Medicine
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Ocular Infections and Treatments
- Optical Imaging and Spectroscopy Techniques
- Optical Coherence Tomography Applications
- Antifungal resistance and susceptibility
- Infrared Thermography in Medicine
- Planarian Biology and Electrostimulation
- Adipose Tissue and Metabolism
- Spectroscopy Techniques in Biomedical and Chemical Research
- Photoreceptor and optogenetics research
- Advanced Fluorescence Microscopy Techniques
- bioluminescence and chemiluminescence research
- Legionella and Acanthamoeba research
- Biological Research and Disease Studies
- Thermoregulation and physiological responses
- Trypanosoma species research and implications
- Medical and Biological Ozone Research
- Bacterial biofilms and quorum sensing
- Porphyrin and Phthalocyanine Chemistry
- Oral health in cancer treatment
- Academic Publishing and Open Access
- Biosensors and Analytical Detection
- Electromagnetic Fields and Biological Effects
Instituto de Pesquisas Energéticas e Nucleares
2013-2024
Energy Research Institute
2023
National Nuclear Energy Commission
2014-2022
Universidade de São Paulo
2016
Ionizing radiation (IR) induces DNA damage and low-level laser therapy (LLLT) has been investigated to prevent or repair detrimental outcomes resulting from IR exposure. Few in vitro studies, however, explore the biological mechanisms underlying those LLLT benefits. Thus, this work, fibroblasts tumor cells are submitted with doses of 2.5 Gy 10 Gy. After twenty-four-h, exposed fluences 30 J cm-2 , 90 150 . Cellular viability, cell cycle phases, proliferation index senescence evaluated on days...
Systemic inflammation is closely related to the development of insulin resistance and type‐2 diabetes, since activation pro‐inflammatory pathways leads inhibition signaling. Although photobiomodulation (PBM) has proven beneficial effects on treatment inflammatory disorders, phototherapeutic approach manage chronic component obesity hyperglycemia had never been explored. In this work, obese hyperglycemic mice are treated with PBM, their body mass, glycemia infiltrate abdominal adipose tissue...
Regulation of inflammation is a critical process for maintaining physiological homeostasis. The λ-carrageenan (λ-CGN) mucopolysaccharide extracted from the cell wall red algae (Chondrus crispus) capable inducing acute intestinal inflammation, which translated into production phase reactants secreted blood circulation. However, associated mechanisms in vertebrates are not well understood. Here, we investigated crucial factors behind inflammatory milieu λ-CGN-mediated administered at 0, 1.75,...
As diabetes causes millions of deaths worldwide every year, new methods for blood glucose monitoring are in demand. Noninvasive approaches may increase patient adherence to treatment while reducing costs, and optical coherence tomography (OCT) be a feasible alternative current invasive diagnostics. This study presents two sugar with OCT vitro. The first, based on spatial statistics, exploits changes the light total attenuation coefficient caused by different concentrations sample using...
Abstract Ventilator‐associated pneumonia (VAP) is an infection that arises after endotracheal intubation affecting patients under intensive care. The presence of the tube (ETT) a risk factor since it colonized by multispecies biofilm. Antimicrobial photodynamic therapy (aPDT) could be strategy to decontaminate ETTs. We verify if methylene blue (MB) associated with external illumination ETT alternative destroy performed in vitro and ex vivo study. In study was P. aeruginosa biofilm grew over...
Our goal was to build, characterize and test a red light-emitting diode (LED) device suitable for wound healing disinfection of biomedical appliances.We designed built unique irradiator metallic box, which irradiation distribution spectral irradiance were calculated.In addition, we explored the device's potential in photobiology comparing irradiated third degree burns with lesions that left heal spontaneously mice.We also compared photodynamic microbial reduction LED-irradiator methylene...
Development of non-invasive techniques for glucose monitoring is crucial to improve control and treatment adherence in patients with diabetes. Hereafter, Optical Coherence Tomography (OCT) may offer a good alternative portable glucometers, since it uses light probe samples. Changes the object interest can alter intensity returning from sample and, through it, one estimate sample's attenuation coefficient (μt) light. In this work, we aimed explore behavior μt mouse's blood under increasing...
The purpose of this paper was to evaluate the effects an oscillating magnetic field (MF) on edema evolution in animal model. Paw induced 32 female Swiss mice by injecting 50 µL 1.0% carrageenan, diluted saline solution left hind footpad. Animals were randomly assigned into four Experimental (exposed different frequencies) and two Control Groups. Groups 1 (0 Hz), 2 (3 3 (9 Hz) 4 (15 exposed for 60 seconds MF (300 mT) first, second, third hour after injection. (CGN DCL) not diclofenac...
Red and near-infrared light have been widely employed in optical therapies. Skin is the most common barrier non-invasive techniques many cases it target tissue itself. Consequently, to optimize outcomes brought by lightbased therapies, properties of skin must be very well elucidated. In present study, we evaluated dorsal albino (BALB/c) pigmented (C57BL/6) mice using Kubelka-Munk photon transport model. We samples from male female young both strains. Analysis was performed for wavelengths at...
Over the last few years, low-level light therapy (LLLT) has shown an incredible suitability for a wide range of applications central nervous system (CNS) related diseases. In this therapeutic modality dosimetry is extremely critical so study propagation through CNS organs great importance. To better understand how intensity delivered to most relevant neural sites we evaluated optical transmission slices rat brain point by point. We experimented red (λ = 660 nm) and near infrared 808...
Metabolic syndrome comprises a constellation of morbidities such as insulin resistance, hyperinsulinemia, atherogenic dyslipidemia, dysglycemia and obesity (especially abdominal). alterations are observed in major target organs, increasing the risk cardiovascular diseases, type-2 diabetes therefore mortality. Tissue characterized by immune cells infiltrates activated macrophages). Released inflammatory mediators TNF-α induce chronic inflammation subjects with metabolic syndrome, since...
Cutaneous leishmaniasis is a neglected parasitic disease that leads to destructive lesions. The emergence of drug resistance has been global concern over the past years. Photodynamic therapy (PDT) mediated by red LED and methylene blue (MB) involves overproduction oxidative stress, which oxidizes several cellular biomolecules prevents selection resistant strains. Herein, we investigated potential PDT MB against wild-type miltefosine-resistant strains Leishmania amazonensis. As result, both...