A5108061746- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Crystal structures of chemical compounds
- Organophosphorus compounds synthesis
- Enzyme function and inhibition
- Advanced biosensing and bioanalysis techniques
- Crystallography and molecular interactions
- Chemical synthesis and alkaloids
- Quinazolinone synthesis and applications
- Synthesis and Reactions of Organic Compounds
- Electric and Hybrid Vehicle Technologies
- Control Systems in Engineering
- Fluorine in Organic Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Metal-Organic Frameworks: Synthesis and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Radical Photochemical Reactions
- Organometallic Complex Synthesis and Catalysis
- DNA and Nucleic Acid Chemistry
- Magnetism in coordination complexes
- Molecular Junctions and Nanostructures
Technical University of Munich
1995-2023
NorthShore University HealthSystem
2023
SUNY Downstate Health Sciences University
2014
State University of New York
2014
University of Southampton
2000-2004
Engineering and Physical Sciences Research Council
2002
Bethel University
2000
Universität Innsbruck
1994
University of Texas Health Science Center at Dallas
1985
University of Georgia
1977
<h3>Importance</h3> Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe well tolerated early-phase human studies. A previous phase II study suggested possible clinical benefit. <h3>Objective</h3> To examine whether CoQ10 could slow progression early PD. <h3>Design, Setting, Participants</h3> III randomized, placebo-controlled, double-blind trial at 67 North...
Toehold-mediated strand displacement (TMSD) has been used extensively for molecular sensing and computing in DNA-based circuits. As these circuits grow complexity, sequence similarity between components can lead to cross-talk, causing leak, altered kinetics, or even circuit failure. For small non-biological circuits, such unwanted interactions be designed against. In environments containing a huge number of sequences, taking all possible into account becomes infeasible. Therefore, general...
Genetic contributions to restless legs syndrome (RLS) have been consistently recognized from population and family studies. To determine the clinical genetic features of RLS in a isolate explore linkage three previously described susceptibility loci on chromosomes 12q, 14q, 9p, respectively, an isolated South Tyrolean Alps was identified 530 adults participated study. Using two-step strategy, 47 patients with idiopathic were ascertained. The prevalence 8.9%. Twenty-eight (59.6%) had at least...
Several recent articles have pointed out that caregivers of patients with frontotemporal dementia (FTD) need counselling and support. To date, however, no support groups been provided other than those available to Alzheimer's disease (AD). At our outpatient unit for cognitive disorders we initiated a specific group FTD. This pilot project had four objectives: 1) provide information, advice caregivers, 2) learn more about the problems needs family carers FTD explore differences caregiver...
Spermine-bridged gem-disubstituted cyclotriphosphazatrienes have been synthesised by two routes. In one route a spermine-bridged cyclophosphazene 2 reacted with monofunctional nucleophiles known to favour gem disubstitution in rings (e.g.tert-butylamine) give 3b, or formation of spiro-derivatives difunctional (e.g. 1,3-propanediol) 3c. the other (i.e. diphenyl, N3P3Ph2Cl4, compound 4) spermine 3a. The >P(N-spiro) group each ring 3a–c is stereogenic and homotopic, so it expected, confirmed,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDehalogenation of organic halides by titanoceneAshot Merijanian, Thomas Mayer, John F. Helling, and Fred KlemickCite this: J. Org. Chem. 1972, 37, 24, 3945–3947Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/jo00797a041https://doi.org/10.1021/jo00797a041research-articleACS PublicationsRequest reuse permissionsArticle...
A chloride selective amide cleft molecule 2 containing two Cr(CO)3 moieties has been synthesised by condensation of (η6-aniline)Cr(CO)3 3 with isophthaloyl dichloride; the X-ray crystal structure contains a network Cr–CO···HN hydrogen bonds giving rise to an extended three-dimensional coordination array; re-determined and found contain bifurcated amine NH···OC–Cr bonds.
Reaction of trans-[PdCl2(DMSO)2], cis-[PtCl2(DMSO)2], and [Cu(OAc)2]⋅H2O with metronidazole (mnz) leads to the formation new complexes, i.e., trans-[PdCl2(mnz)2] (1), trans-[PtCl2(mnz)2] (2), trans-[Cu2(OAc)4(mnz)2] (3), respectively. Complexes 1–3 crystallize all in centrosymmetric monoclinic space group P21/c Z=8. Unit-cell parameters for these complexes are: 1, a=7.1328(14) Å, b=20.699(4) c=7.1455(14) β=116.17(3)°; 2, a=6.9169(14) b=21.853(4) c=6.7218(13) β=110.79(3)°; 3, a=9.1663(18)...
A systematic study is presented on the products of aminolysis N(3)P(3)Cl(6) (1) and N(3)P(3)Ph(2)Cl(4) (4) with dibenzylamine. Two series mono- disubstituted derivatives compounds (4), namely N(3)P(3)Cl(5)[N(CH(2)Ph)(2)] (2) N(3)P(3)Cl(4)[N(CH(2)Ph)(2)](2) (3) N(3)P(3)Ph(2)Cl(3)[N(CH(2)Ph)(2)] (5) N(3)P(3)Ph(2)Cl(2)[N(CH(2)Ph)(2)](2) (6) [where (2), (3), are new structures], investigated in order to determine whether steric or electronic effects prevail formation dibenzylamino-substituted...
The differentiation of posterobasal myocardial infarction (PMI) from either right ventricular hypertrophy (RVH) or normal subjects displaying an anterior loop (AL) by electrocardiography (ECG) vectorcardiography (VCG) is difficult. M-mode echocardiography (echo) via the and subxiphoid methods has been helpful in defining cardiac chamber size wall motion abnormalities. We tested whether this relatively more direct method would better separate these entities compared with other two techniques....
A systematic study is reported of the products nucleophilic substitution reactions spermine-bridged cyclotriphosphazene, [N3P3X4(NHCH2CH2CH2N)CH2CH2]2 [where X = Cl (2a)], to give a number new structures [(2b)-(2g)] in which OPh, [spiro-O(CH2)3O]0.5, Ph, NHPh, NC4H8 and NHBut, respectively. comparison has been made between sum substituent basicity constants, Sigmaalpha(R), obtained nitrobenzene solution, ten molecular parameters N3P3 ring (the internal bond angles alpha, beta, gamma, delta...
A systematic study of the products nucleophilic substitution reactions cis-ansa N(3)P(3)Ph(2)[O(CH(2)CH(2)O)(4)]Cl(2) (3) is reported. These give a number new structures with general formula N(3)P(3)Ph(2)[O(CH(2)CH(2)O)(4)]R(2) [where R = OCH(2)CF(3) (4), OPh (5), OMe (6), NHPh (7 x H(2)O), NHBu(t) (8)]. comparison has been made between sum substituent basicity constants, Sigmaalpha(R), that are obtained in nitrobenzene solution and eight molecular parameters N(3)P(3) ring [the P-N bond...
In this paper the design of a robust control system for parallel hybrid drivetrain is presented. The based on continuously variable transmission (CVT) and therefore highly nonlinear multiple-input-multiple-output (MIMO-System). Input-Output-Linearization offers possibility linearizing decoupling system. Since example vehicle mass varies with load efficiency gearbox depends strongly actual working point, an exact linearization plant will mostly fail. Therefore algorithm sliding mode used to...
Abstract The synthesis of benzazepine analogues the opium alkaloid noscapine ( 1 ) is described. benzazepines 2 and 3 were prepared starting from nornarceine ethyl ester 4 ; readily available in several steps. X‐Ray analysis compound revealed that it not a diastereosisomer mixture but racemate threo ‐form thus has same configuration as .
The title compound, [Mg3(C2H3O2)6(C2H6O)2]·2C2H6O, contains infinite chains of magnesium ions bridged by acetate ligands in three different coordination modes. There are two independent MgII the asymmetric unit, and one lies on a twofold axis. geometry around each Mg ion is distorted octahedral.
ABSTRACT Toehold-mediated strand displacement (TMSD) has been used extensively for molecular sensing and computing in DNA-based circuits. As these circuits grow complexity, sequence similarity between components can lead to cross-talk causing leak, altered kinetics, or even circuit failure. For small non-biological circuits, such unwanted interactions be designed against. In environments containing a huge number of sequences, taking all possible into account becomes infeasible. Therefore,...
Mildtraumatic brain injury (mTBI) is a major health issue comprising aheterogeneous and complex array of pathologies. Little understood about the mechanisms secondary in evolution damage after mTBI; however an apparent hepatic‐neural communication may generate systemic inflammatory response (SIR). A stress‐mediated release cortisol catecholamines can enhance SIR, leading to immunological dysfunction causing retardation healing infrastructure. This study investigated role SIR TBI male Wistar...