A5011820630- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Diet and metabolism studies
- Medication Adherence and Compliance
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Sports Performance and Training
- Heart Failure Treatment and Management
- Exercise and Physiological Responses
- Health and Wellbeing Research
- Chronic Disease Management Strategies
- School Health and Nursing Education
- Body Composition Measurement Techniques
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Vitamin D Research Studies
- Health Literacy and Information Accessibility
- Management and Marketing Education
- Youth Development and Social Support
- Bone health and osteoporosis research
- Physical Activity and Health
- Health Policy Implementation Science
- Sports injuries and prevention
- Health and Well-being Studies
- Cholesterol and Lipid Metabolism
University of Limerick
2013-2024
Food for Health Ireland
2015-2021
Healthy Start
2021
University College Dublin
2019
Emory University
2009-2012
Cleveland Clinic
2012
Stanford University
2012
ING Direct
2011
Universidade Federal de Minas Gerais
2010
Kaiser Permanente
2010
The Notch signaling pathway is an evolutionarily conserved intercellular mechanism essential for embryonic development in mammals. Mutations the human JAGGED1 (JAG1) gene, which encodes a ligand family of transmembrane receptors, cause autosomal dominant disorder Alagille syndrome. We have examined vivo role mouse Jag1 gene by creating null allele through targeting. Mice homozygous mutation die from hemorrhage early during embryogenesis, exhibiting defects remodeling and yolk sac...
In aging men, the prostate gland becomes hyperproliferative and displays a propensity toward carcinoma. Although this process has been proposed to represent an inappropriate reactivation of embryonic differentiation program, regulatory genes responsible for normal development function are largely undefined. Here we show that murine Nkx3.1 homeobox gene is earliest known marker epithelium during embryogenesis subsequently expressed at all stages in vivo as well tissue recombinants. A null...
Rulang Jiang, Yu Lan, Harry D. Chapman, Carrie Shawber, Christine R. Norton, David V. Serreze, Gerry Weinmaster, and Thomas Gridley The Jackson Laboratory, Bar Harbor, Maine 04609 USA; Department of Biological Chemistry, University California, Los Angeles (UCLA), School Medicine, Angeles, California 90024 USA
The revised European consensus defined sarcopenia as a progressive and generalized skeletal muscle disorder that is associated with an increased likelihood of adverse outcomes including falls, fractures, physical disability mortality. aim this study was to determine the prevalence analyse influence diet, activity (PA) obesity index risk factors each criteria sarcopenia. A total 629 middle-aged older adults were enrolled in cross-sectional study. Anthropometrics assessed. Self-reported PA...
Optimal athletic performance relies on meeting specific nutritional requirements, encompassing adequate calorie intake, macronutrient and hydration. Misinformation or misconceptions about these necessities are prevalent among young athletes. This study investigated nutrition hydration knowledge practices 28 male rugby union players aged 16 to 17, participating in Munster Rugby’s 2023 Summer Age-Grade Development Programme, specifically the U18′s Schools Squad. The Nutrition for Sport...
Background— Studies on the incidence and predictors of heart failure (HF) are often restricted to elderly persons or identify only inpatient cases. Methods Results— We determined new HF diagnosed in either outpatient settings, among 359 947 women men (age ≥18 years) insured by Kaiser Permanente Georgia at any time during calendar years 2000 2005. Subjects were free baseline, incident was identified with ICD-9 codes (1 2 visits). developed multivariable Cox models assess association...
Abstract The age-related decline in functional capability is preceded by a reduction muscle quality. purpose of this study was to assess the combined effects progressive resistance training (PRT) and protein supplementation beyond habitual intakes on upper leg lean tissue mass (LTM), quality healthy 50–70 years women. In single-blinded, randomized, controlled design, 57 older women (age 61.1 ± 5.1 years, 1.61 0.65 m, 65.3 15.3 kg) consumed 0.33 g/kg body milk-based matrix (PRO) for 12 weeks....
Abstract There are conflicting reports both within the lay media and scientific literature regarding use benefit of dietary practices that aim to reduce CHO intake in endurance athletes. This study aimed determine prevalence intentional reduction fasted training elite endurance‐based athletes using a semi‐quantitative questionnaire. Bone is nutritionally modulated tissue; therefore, this also explore if these potentially associated with bone injury incidence. The reported was prevalent (28%)...
The Mediterranean diet (MD) shows the strongest evidence in support of healthy aging and prevention age-related diseases. It is associated with a decreased risk chronic disease, such as cardiovascular obesity, hypertension, diabetes mellitus cognitive disease. Given health-promoting aspects this diet, we conducted secondary analysis data from LifeAge study (“Promoting shift: sedentary Lifestyle towards active Ageing-LifeAge” Project No 603121-EPP-1-2018-1-ES-SPO-SCP) primary aim to determine...
The aim of this study was to test the effects two disparate isonitrogenous, isocaloric pre-exercise feeds on deuterium-oxide (D2O) derived measures myofibrillar protein synthesis (myoPS) in humans. Methods: In a double-blind parallel group design, 22 resistance-trained men aged 18 35 years ingested meal (6 kcal·kg-1, 0.8 g·kg-1 carbohydrate, 0.2 fat) with 0.33 nonessential amino acids blend (NEAA) or whey (WHEY), prior resistance exercise (70% 1RM back-squats, 10 reps per set failure, 25%...
The aim of this study was to investigate the effect whey protein supplementation on myofibrillar synthesis (myoPS) and muscle recovery over a 7-d period intensified resistance training (RT).In double-blind randomised parallel group design, 16 resistance-trained men aged 18 35 years completed RT protocol, consisting three lower-body sessions non-consecutive days. Participants consumed controlled diet (146 kJ·kg-1·d-1, 1.7 g·kg-1·d-1 protein) with either supplement or an isonitrogenous control...
The hospital discharge rate of children less than 15 years age in the United States declined 12% from 1983 to 1984. This was first time 20-year history National Hospital Discharge Survey that there a statistically significant decrease children's rates 1-year period. change occurred during period when prospective payment systems were introduced and prepaid group health plans alternative providing care expanding. unprecedented use evaluated using data Survey. is continuous survey which...
Abstract Crohn’s disease (CD) is a debilitating inflammatory bowel condition of unknown aetiology that growing in prevalence globally. Large-scale studies have determined associations between female obesity or low body mass index (BMI) with risk CD at all ages 8– < 40 years, respectively. For males, BMI entering adult life associated increased incidence ulcerative colitis up to years later. Body composition analysis has shown combinations lean tissue loss and high visceral fat predict...
Dietary calcium intake is a modifiable, lifestyle factor that can affect bone health and the risk of fracture. The diurnal rhythm remodelling suggests nocturnal dietary intervention to be most effective. This study investigated effect daily, bed-time ingestion calcium-fortified, milk-derived protein matrix (MBPM) or control (CON), for 24 weeks, on serum biomarkers resorption (C-terminal telopeptide type I collagen, CTX) formation (serum pro-collagen 1 N-terminal propeptide, P1NP),...
The diurnal rhythm of bone remodeling suggests nocturnal dietary intervention to be most effective. This study investigated the effect bedtime ingestion a calcium-fortified, milk-derived protein matrix (MBPM) or maltodextrin (CON) on acute (0-4 h) blood and 24-h urinary change in biomarkers postmenopausal women with osteopenia. In CON, participants received 804 ± 52 mg calcium, 8.2 3.2 µg vitamin D 1.3 0.2 g/kg BM per day. MBPM increased calcium intake 1679 196 mg, 9.2 3.1 1.6 BM. Serum...
Summary Whole-of-school programmes (WSPs) are recommended to promote physical activity for adolescents. The Active School Flag (ASF) programme secondary-level schools is one such WSP. Due the difficulties of incorporating WSPs into complex school system, there a risk poor implementation. monitoring unanticipated influences can help understand key implementation processes prior scale-up. aims this study were identify perceived facilitators and barriers implementing ASF recommend...