A5084200596- Nanoparticle-Based Drug Delivery
- Iron oxide chemistry and applications
- Characterization and Applications of Magnetic Nanoparticles
- Kidney Stones and Urolithiasis Treatments
- Lipid Membrane Structure and Behavior
- Antimicrobial Peptides and Activities
- nanoparticles nucleation surface interactions
- Healthcare and Venom Research
- Monoclonal and Polyclonal Antibodies Research
- thermodynamics and calorimetric analyses
- Microfluidic and Bio-sensing Technologies
- Advanced MRI Techniques and Applications
- Iron Metabolism and Disorders
- Organ Donation and Transplantation
- Electrostatics and Colloid Interactions
- Pediatric Urology and Nephrology Studies
- Bacteriophages and microbial interactions
- Protein purification and stability
- Diatoms and Algae Research
- Minerals Flotation and Separation Techniques
- Paleopathology and ancient diseases
Technical University of Munich
2021-2024
New drug delivery systems are a potential solution for administering drugs to reduce common side effects of traditional methods, such as in cancer therapy. Iron oxide nanoparticles (IONs) can increase the drugs’ biological activity through high binding efficiency and magnetically targeted delivery. Understanding adsorption release process carrier material plays significant role research generate an applicable controlled system. This contribution focuses on patterns peptide lasioglossin III...
Iron oxide nanoparticles (IONs) are of great interest in nanomedicine for imaging, drug delivery, or hyperthermia treatment. Although many research groups have focused on the synthesis and application IONs nanomedicine, little is known about influence surface properties particles' behavior human body. This study analyzes impact coatings (dextran, polyvinyl alcohol, polylactide-co-glycolide) nanoparticles' cytocompatibility, agglomeration, degradation, resulting oxidative stress induced by...
Carboxymethyl-dextran (CMD)-coated iron oxide nanoparticles (IONs) are of great interest in nanomedicine, especially for applications drug delivery. To develop a magnetically controlled delivery system, many factors must be considered, including the composition, surface properties, size and agglomeration, magnetization, cytocompatibility, activity. This study reveals how CMD coating thickness can influence these particle properties. ION@CMD synthesized by co-precipitation. A higher quantity...
Coated iron oxide nanoparticles (IONs) are promising candidates for various applications in nanomedicine, including imaging, magnetic hyperthermia, and drug delivery. The application of IONs nanomedicine is influenced by factors such as biocompatibility, surface properties, agglomeration, degradation behavior, thrombogenicity. Therefore, it essential to investigate the effects coating material thickness on behavior performance human body. In this study, with a carboxymethyl dextran (CMD) two...
Magnetic nanoparticles (MNPs) are used for magnetophoresis-based separation processes in various biomedical and engineering applications. Essential requirements the colloidal stability of MNPs ability to be separated even low magnetic field gradients. Bare iron oxide (BIONs) with a diameter 9.2 nm synthesized via coprecipitation, exhibiting high saturation magnetization 70.84 Am2 kg−1 no remanence. In our study, zeta potential, dynamic light scattering (DLS), sedimentation analysis show that...
Abstract Silica-coated iron oxide nanoparticles are of enormous importance in biotechnology, nanomedicine, and catalysis. The study demonstrates the significant influence coating thickness on particle properties. Though slow magnetophoresis, a thinner shell leads to higher surface areas, lower isoelectric points, magnetizations. However, thick layers prevent oxidation lead stabilization. influenced binding cationic peptide lasioglossin, with maximal loading 0.23 g −1 for smallest particles....
The secretion and direct capture of proteins from the extracellular medium is a promising approach for purification, thus enabling integrated bioprocesses.We demonstrate nanobody (VHH) to (EM) its by bare, non-functionalized magnetic nanoparticles (MNPs). An ompA signal peptide periplasmic localization, polyglutamate-tag (E8 ) selective MNP binding, factor Xa protease cleavage site were fused N-terminally nanobody. production E8 -VHH (36 mg L-1 was enabled using growth-decoupled Escherichia...
Abstract Residual fragments can remain after kidney stone extraction which may necessitate another intervention. A new approach needs to be developedis needed lower the risk of disease severe side effects caused by these fragments. Magnetic nanoparticles applied due their properties being able bind residual and extracted an external magnetic field. Fractals have been synthesized characterized thoroughly. The small covalently stones a calcium oxalate fractals with is possible. aggregation...
You have accessJournal of UrologyStone Disease: Surgical Therapy (Including ESWL) III (MP29)1 May 2024MP29-09 THE MAGNETIC FORCE: SRF EXTRACTION IN LIVING PORCINE MODELS Thomas Amiel, Chiara Turrina, Shyam Srinivasan, Florian Ebel, Sami Fourati, Julian Häussler, Melanie Niebuhr, Robert Bischoff, Sebastian Schwaminger, and Michael Straub AmielThomas Amiel , TurrinaChiara Turrina SrinivasanShyam Srinivasan EbelFlorian Ebel FouratiSami Fourati HäusslerJulian Häussler NiebuhrMelanie Niebuhr...
Abstract The primary objective of urolithiasis therapy is complete stone removal and highest stone-clearance rates possible to minimize recurrence. A novel approach that employs a magnetic suspension probe for the passive collection small residual fragments was developed. This study assessed feasibility this system in porcine models. Five female domestic pigs underwent retrograde intrarenal surgery under general anaesthesia assess new system. Pre-analysed human calculi were endoscopically...
Iron oxide nanoparticles (IONs) are of great interest in nanomedicine for imaging, drug delivery, or hyperthermia treatment. Although many research groups have focused on the synthesis and application IONs nanomedicine, little is known about influence surface properties particles’ behavior human body. This study analyzed impact standard coating materials (dextran, polyvinyl alcohol, polylactide-co-glycolide) with an improved experimental setting IONs’ cytocompatibility, degradation,...
Abstract Superparamagnetic iron oxide nanoparticles are a promising material in nanomedicine, especially for generating magnetically controlled drug delivery systems. We developed an innovative ureidopyrimidinone (UPy) coating based on supramolecular hydrogen bonding units. The synthesized possess positively charged surface with hydrodynamic diameter of 177 nm at pH 7 and magnetization 31 emu g -1 . system has the potential to be modified by drugs or bioactive molecules altered UPy
Antimicrobial peptides (AMPs) can kill bacteria by disrupting their cytoplasmic membrane, which reduces the tendency of antibacterial resistance compared to conventional antibiotics. Their possible toxicity human cells, however, limits applicability. The combination magnetically controlled drug delivery and supramolecular engineering help reduce dosage AMPs, control delivery, improve cytocompatibility. Lasioglossin III (LL) is a natural AMP form bee venom that highly antimicrobial. Here,...