A5086792125- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Climate Change and Health Impacts
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Nutrition, Genetics, and Disease
- Global Cancer Incidence and Screening
- Cardiac electrophysiology and arrhythmias
- Metabolomics and Mass Spectrometry Studies
- Venomous Animal Envenomation and Studies
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Pharmacogenetics and Drug Metabolism
- Gastric Cancer Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Health Care Issues
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
Mashhad University of Medical Sciences
2021-2025
Washington University in St. Louis
2024-2025
Abstract Studying the effects of microbiome on development different types cancer has recently received increasing research attention. In this context, microbial content organs gastrointestinal tract been proposed to play a potential role in pancreatic (PC). Proposed mechanisms for pathogenesis PC include persistent inflammation caused by microbiota leading an impairment antitumor immune surveillance and altered cellular processes tumor microenvironment. The limited available diagnostic...
Abstract Since 1997, highly pathogenic avian influenza viruses, such as H5N1, have been recognized a possible pandemic hazard to men and the poultry business. The rapid rate of mutation H5N1 viruses makes whole process designing vaccines extremely challenging. Here, we used an in silico approach design multi-epitope vaccine against A virus using hemagglutinin (HA) neuraminidase (NA) antigens. B-cell epitopes, Cytotoxic T lymphocyte (CTL) Helper (HTL) were predicted via IEDB, NetMHC-4...
Abstract Background To understand potential racial differences in disease susceptibility and develop targeted prevention strategies, it is essential to establish biological between groups healthy individuals. However, knowledge about how race impacts metabolites limited. We therefore performed a cross-sectional study using comprehensive metabolomics analysis investigate among 506 non-Hispanic White (NHW) women 163 Black (NHB) women. Methods untargeted plasma metabolomic profiling Metabolon’s...
Background: Stomach adenocarcinoma (STAD) is a common cancer with poor clinical outcomes globally. Due to lack of early diagnostic markers disease, the majority patients are diagnosed at an advanced stage. Objective: The aim present study provide some new insights into available biomarkers for STAD using bioinformatics. Methods: RNA-Sequencing and other relevant data from Cancer Genome Atlas (TCGA) database were evaluated identify differentially expressed genes (DEGs). Then, Machine Learning...
Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis. Therefore, there has been focus on identifying new biomarkers for its early diagnosis and the prediction of patient survival. Genome-wide RNA microRNA sequencing, bioinformatics Machine Learning approaches to identify differentially expressed genes (DEGs), followed by validation in an additional cohort PDAC patients undertaken. To DEGs, genome sequencing clinical data from pancreatic cancer were extracted The...
Abstract Background- Cervical cancer, ranking fourth in prevalence among women worldwide, is highly preventable when diagnosed early. The advent of innovative technologies including bioinformatics and machine learning, revolutionizing the discovery development novel biomarkers for cancer. Our study uniquely integrates artificial neural networks with RNA-sequencing data cervical cancer patients. This combination enhances accuracy reliability biomarker predictions, providing a better...
Background: Cervical cancer is one of the most prevalent gynecologic cancers associated with high morbidity and mortality worldwide. There mounting evidence indicating an association between 9p21 locus genetic variants susceptibility to various human malignancies. In this current study, we aimed evaluate potential relationship rs1333049 variant in chromosome risk cervical carcinogenesis. Methods: The possible correlation polymorphism was investigated 221 patients or without cancer. DNAs were...
Abstract Non-alcoholic fatty liver disease (NAFLD) comprises a range of chronic diseases that result from the accumulation excess triglycerides in liver, and which, its early phases, is categorized NAFLD, or hepato-steatosis with pure liver. The mortality rate non-alcoholic steatohepatitis (NASH) more than NAFLD; therefore, diagnosing stages may decrease damage increase survival rate. In current study, we screened gene expression data NAFLD patients control samples public dataset GEO to...
Abstract: Pancreatic cancer (PC) is one the most lethal malignancies worldwide affecting around half a million individuals each year. The treatment of PC relatively difficult due to difficulty in making an early diagnosis. Transforming growth factor-beta (TGF-β) multifunctional factor acting as both tumor promoter stages and suppressor advanced disease. Programmed death-ligand 1 (PD-L1) ligand programmed death-1 (PD-1), immune checkpoint receptor, allowing cells avoid elimination by cells....
Cytochrome P450 (CYP450) enzyme has been shown to be expressed in colorectal cancer (CRC) and its dysregulation is linked tumor progression a poor prognosis. Here we investigated the therapeutic potential of targeting CYP450 using lopinavir/ritonavir CRC. The integrative systems biology method RNAseq were utilized investigate differential levels genes associated with patients cancer. antiproliferative activity was evaluated both monolayer 3-dimensional (3D) models, followed by wound-healing...
Colorectal cancer (CRC) is a common associated with poor outcomes, underscoring need for the identification of novel prognostic and therapeutic targets to improve outcomes. This study aimed identify genetic variants differentially expressed genes (DEGs) using genome-wide DNA RNA sequencing followed by validation in large cohort patients CRC.
The precise and exquisite architecture of the retina is directly related to vision. Therefore, any mechanisms associated with disruption retinal structure could affect quality A large number studies indicated that several cellular molecular processes are involved in pathogenesis. Among different risk factors reported as important players diseases, deregulation epigenetic contributors has critical roles pathogenesis these diseases. MicroRNAs (miRNAs) a type small non-coding RNAs various...
Abstract Introduction: Lipids are important for many cellular processes and have been implicated in cancer development. Adopting a lipidomic approach has revealed sex-specific differences lipid species but whether there racial profiles remain unexplored. As result, we investigated between Non-Hispanic Black (NHB) vs White (NHW) women. Methods: We performed profiling on 705 premenopausal women who were recruited during their annual screening mammogram at Washington University School of...