A5029287698- Inflammatory Bowel Disease
- Intestinal and Peritoneal Adhesions
- Gut microbiota and health
- Nanoparticle-Based Drug Delivery
- Pregnancy and Medication Impact
- Hormonal Regulation and Hypertension
- Nanoparticles: synthesis and applications
- Microscopic Colitis
- Muscle Physiology and Disorders
- Drug Transport and Resistance Mechanisms
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Pharmacological Effects of Natural Compounds
- Colorectal Cancer Treatments and Studies
- Hernia repair and management
- Muscle metabolism and nutrition
- Cancer, Lipids, and Metabolism
- Ziziphus Jujuba Studies and Applications
- Hydrogen's biological and therapeutic effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pharmacogenetics and Drug Metabolism
- Omental and Epiploic Conditions
- Exercise and Physiological Responses
- Probiotics and Fermented Foods
- Endometriosis Research and Treatment
Mashhad University of Medical Sciences
2020-2025
Health First
2024
Introduction: Cervical cancer is the leading cause of cancer-related death in women, so novel therapeutic approaches are needed to improve effectiveness current therapies or extend their activity. In recent decades, graphene analogs, such as Mxene, an emerging class two-dimensional (2D) have been drawing considerable attention based on intrinsic physicochemical properties and performance potential candidates for tumor therapy, particularly purposes. Here we explored targeted drug delivery...
The modulating factors within the tumor microenvironment, for example, transforming growth factor beta (TGF-β), may limit response to chemo and immunotherapy protocols in colorectal cancer (CRC). In current study, therapeutic potential of targeting TGF-β pathway using Pirfenidone (PFD), a inhibitor, either alone or combination with five fluorouracil (5-FU) has been explored preclinical models CRC. anti-proliferative migratory effects PFD were assessed by MTT wound-healing assays...
Inflammatory bowel disease (IBD) is a persistent inflammation of the digestive system, and Mesenchymal Stem Cells (MSCs) their exosomes have demonstrated potential as treatments for this condition. The objective research was to examine possible effectiveness intraperitoneal injection umbilical cord-MSCs (UC-MSCs) through two-time regimen in mouse model. In study, an animal model specific type IBD C57BL/6 mice, induced by dextran sulfate sodium (DSS), utilized. mice were treated with MSCs,...
Introduction The therapeutic efficacy of oral administration Ziziphus jujube in the context uterine adhesion (UA) and its impact on pregnancy outcomes was investigated. Methods In a rat UA model, Z. evaluated for ability to mitigate injury-induced bands, shortening, enhance endometrial regeneration. assessment included analysis gland numbers, thickness, regulation inflammatory cytokines. antioxidant properties were also studied through enzyme activity tissue homogenates. Fibrotic changes...
Despite recent advances in surgical procedures, postoperative peritoneal adhesions are common following major abdominopelvic surgery. Here, the therapeutic potential of Punica granatum var. pleniflora (PGP) on has been explored a rat uterine horn adhesion model. Eighteen Albino Wistar female rats were divided into three groups: control group, sham, and treatment group receiving 400 mg/kg/day PGP orally for ten days. An identical technique was employed to induce both groups. At end...
Colorectal cancer (CRC) is a serious health problem, and finding new treatments important. There growing evidence for the antitumor activity of probiotics. This study investigated anti-cancer potential probiotic mix containing Lactobacillus plantarum, L. brevis, helveticus, delbrueckii, alone or in combination with chemotherapy drug 5-fluorouracil, against CRC. The research was carried out Mashhad 2021. cytotoxic effect isolates on CRC cells two-dimensional three-dimensional cell culture...
Introduction: Breast cancer is one of the most prevalent malignancies among women around world. Crocus sativus, a natural food coloring and flavoring, has potent anti-tumor properties. The aim current study was to investigate therapeutic potential crocin, main pharmacological active component saffron, either alone or in combination with standard chemotherapeutic treatment, 5-FU, (BC) progression both cellular animal models. Material Methods: MTT, Real-Time PCR, Western Blotting, Hematoxylin...
Abstract There are significant challenges in developing drug carriers for therapeutic perspective. We have investigated a novel nanocarrier system, based on combining functionalized magnetic nanocomposite with Metal–Organic Frameworks (MOFs). Magnetic nanoparticles modified using biocompatible copolymers may be suitable delivering hydrophobic drugs, such as cisplatin. Furthermore, compared to polymeric nanocarriers, constructed from zeolitic imidazolate framework-8 (ZIF-8) demonstrated...
Abstract Background Adhesion band formation is a common cause of morbidity for patients undergoing surgeries. Anti-inflammatory and anti-fibrotic properties curcumin, pharmacologically active component Curcuma longa , have been investigated in several studies. The aim this study to explore the therapeutic potential curcumin attenuating post-operative adhesion (PSAB) both peritoneal peritendinous surgeries animal models. Methods Bio-mechanical, histological quantitative evaluation...
Colorectal cancer (CRC) is an important cause of cancer-related mortality. Aberrant activation the renin-angiotensin system (RAS) reported to be associated with poor clinical outcomes in patients CRC. This study was designed explore anti-tumor effects angiotensin receptor blocker Candesartan either alone or combination 5-FU vitro and vivo models The cytotoxic were assessed using MTT assay two colorectal cell lines (CT-26 SW-480). To investigate potential regulatory role on tumor growth,...
The development of carriers for drug delivery faces significant challenges from a therapeutic perspective. present study presents an innovative nanocarrier based on combination functionalized magnetic nanocomposite nano‐chitosan and cisplatin. Hydrophobic drugs such as cisplatin could be delivered using nanoparticles modified with biocompatible copolymers. This aimed to determine the antitumor effects free enhancement in cervical cancer cells cisplatin‐encapsulated Fe 3 O 4 @SiO 2...
Inflammatory bowel disease (IBD) is defined by the chronic inflammation of digestive tract. Ulcerative colitis one most prevalent IBDs. The increase in mucosal expression angiotensin II (AT-II) suggests a possible role AT-II colitis-associated inflammation. Here, we examined potential therapeutic effects combination therapy regarding valsartan (Val), as an receptor blocker, with sulfasalazine (SSZ) murine model. DSS induced was initiated administration dextran sodium sulfate (DSS) male...
Background: Intra-abdominal adhesions are a commonly occurring postoperative complication following abdominopelvic surgery. Peritoneal adhesion formation can lead to infertility, chronic pelvic pain, and intestinal obstruction. The anti-inflammatory anti-oxidant activities of Ganoderma lucidum Karst (G. lucidum) Ziziphus jujuba Mill (Z. jujuba) have been reported. Here, we explored the therapeutic potential Z. against postsurgical band formation. NC3Rs ARRIVE guidelines were followed during...
Abstract Oxidative stress has an important role in brain aging and its consequences include cognitive decline physiological disorders. Peroxisome proliferator‐activated receptor‐γ (PPARγ) activation been suggested to decrease oxidative stress. In the current research, effect of PPARγ by pioglitazone(Pio) on learning, memory was evaluated aged rats. The rats were divided into five groups. Control group, vehicle (saline‐diluted dimethyl sulfoxide (DMSO)) saline injected instead Pio scopolamine...
Cytochrome P450 (CYP450) enzyme has been shown to be expressed in colorectal cancer (CRC) and its dysregulation is linked tumor progression a poor prognosis. Here we investigated the therapeutic potential of targeting CYP450 using lopinavir/ritonavir CRC. The integrative systems biology method RNAseq were utilized investigate differential levels genes associated with patients cancer. antiproliferative activity was evaluated both monolayer 3-dimensional (3D) models, followed by wound-healing...