A5022479208- Gut microbiota and health
- Congenital heart defects research
- Zebrafish Biomedical Research Applications
- Sulfur Compounds in Biology
- Pesticide Exposure and Toxicity
- Tryptophan and brain disorders
- COVID-19 Clinical Research Studies
- Colorectal Cancer Treatments and Studies
- Pharmacogenetics and Drug Metabolism
- Biochemical effects in animals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Neurological Disease Mechanisms and Treatments
- Curcumin's Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle metabolism and nutrition
- Alzheimer's disease research and treatments
- Muscle Physiology and Disorders
- Patient-Provider Communication in Healthcare
- Physiological and biochemical adaptations
- Ginkgo biloba and Cashew Applications
- Medical Coding and Health Information
- Flavonoids in Medical Research
Mashhad University of Medical Sciences
2023-2025
Shahid Beheshti University of Medical Sciences
2020-2024
University of Tabriz
2024
Islamic Azad University, Karaj
2023
City University of Hong Kong
2013-2021
Ardabil University of Medical Sciences
2020
University of Mazandaran
2019
Qazvin University of Medical Sciences
2018
Tarbiat Modares University
2010-2017
Urmia University
2017
Zebrafish is an important model organism in biological research. One of the least explored tissues zebrafish blood, because existing methods for isolating blood from this are tedious and irreproducible. The small volume collected by these also prohibits many biochemical cytological analyses. This technical obstacle limits utilization applications, particularly hematological research plasma biomarker discovery. To overcome limitation, we have established a novel method extracting zebrafish,...
One attractive quality of zebrafish as a model organism for biological research is that transparency at early developmental stages allows the optical imaging cellular and molecular events. However, this advantage cannot be applied to adult zebrafish. In study, we explored use contrast-enhanced X-ray micro-computed tomography (microCT) on in which was stained with iodine, simple economical contrasting agent, after fixation. Tomographic reconstruction microCT data allowed three-dimensional...
The brain is sensitive to oxidative stress, which can trigger microglial activation and neuroinflammation. Antioxidant therapies may provide neuroprotection against stress. In recent years antioxidant effects of probiotics their possible mechanisms in stress-related models have been determined. the current study, for first time, we assessed
Sexual differences have been observed in the onset and prognosis of human cardiovascular diseases, but underlying mechanisms are not clear. Here, we found that zebrafish heart regeneration is faster females, can be accelerated by estrogen suppressed estrogen-antagonist tamoxifen. Injuries to heart, other tissues, increased plasma levels expression receptors, especially esr2a. The resulting endocrine disruption induces female-specific protein vitellogenin male zebrafish. Transcriptomic...
The modulating factors within the tumor microenvironment, for example, transforming growth factor beta (TGF-β), may limit response to chemo and immunotherapy protocols in colorectal cancer (CRC). In current study, therapeutic potential of targeting TGF-β pathway using Pirfenidone (PFD), a inhibitor, either alone or combination with five fluorouracil (5-FU) has been explored preclinical models CRC. anti-proliferative migratory effects PFD were assessed by MTT wound-healing assays...
Introduction: Cervical cancer is the leading cause of cancer-related death in women, so novel therapeutic approaches are needed to improve effectiveness current therapies or extend their activity. In recent decades, graphene analogs, such as Mxene, an emerging class two-dimensional (2D) have been drawing considerable attention based on intrinsic physicochemical properties and performance potential candidates for tumor therapy, particularly purposes. Here we explored targeted drug delivery...
Cytochrome P450 (CYP450) enzyme has been shown to be expressed in colorectal cancer (CRC) and its dysregulation is linked tumor progression a poor prognosis. Here we investigated the therapeutic potential of targeting CYP450 using lopinavir/ritonavir CRC. The integrative systems biology method RNAseq were utilized investigate differential levels genes associated with patients cancer. antiproliferative activity was evaluated both monolayer 3-dimensional (3D) models, followed by wound-healing...
The reduced alpha1-antitrypsin (AAT) activities of some phenotypes have been suggested as contributing to the development respiratory diseases.One hundred patients with disease following exposure sulfur mustard were divided into two groups 50 based on their symptoms and compared a healthy control group. AAT determined in plasma all patient subjects by isoelectric focusing (IEF).Mean 3.4 +/- 0.3 4.2 0.1 micromol min(-1) ml(-1), respectively (p < 0.001). No phenotypic alterations detected.The...
Recent studies have indicated that dysfunction of gut microbiota, living microorganisms the digestive tract, plays a role in pathogenesis neurodegenerative disorders, indicating valuable impact probiotics as potential preventive or therapeutic strategy. Saccharomyces boulardii is yeast probiotic with beneficial effects on various ranging from inflammatory gastrointestinal diseases to brain and behavioral disorders. Herein, we examined effect S. memory impairment induced by lipopolysaccharide...
Background: Truth disclosure is one of the major challenges for physicians with cancer patients. The attitude toward breaking news adopted by individuals depends on their cultural background. present study was conducted at Ardabil University Medical sciences, Ardabil, Iran, to investigate attitudes Turkish-speaking patients and families bad news. Materials Methods: descriptive cross-sectional used convenience sampling select 62 patients, 76 family members young 58 children. mean age 37.29...
Muscle atrophy due to limb immobilization and inactivity is a common consequence of many diseases treatment processes. One the systems activated in inflammatory conditions renin-angiotensin system (RAS). The present study was conducted with aim investigating effects one angiotensin-converting enzyme (ACE) inhibitors, enalapril, on improving muscle caused by immobility. three groups: control, an atrophy, group treated enalapril Balb/c mice. After tying splint cause legs, daily...