A5036831129- Microfluidic and Bio-sensing Technologies
- Ion Channels and Receptors
- Biochemical and Molecular Research
- Metabolism and Genetic Disorders
- bioluminescence and chemiluminescence research
- Redox biology and oxidative stress
- Nanoplatforms for cancer theranostics
- Biochemical effects in animals
- Brain Metastases and Treatment
- Acoustic Wave Phenomena Research
- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Cancer, Hypoxia, and Metabolism
- Ion channel regulation and function
- Electrostatics and Colloid Interactions
University of Göttingen
2020-2022
Universitätsmedizin Göttingen
2022
Consejo Superior de Investigaciones Científicas
2017
Melanoma is the deadliest of skin cancers and has a high tendency to metastasize distant organs.Calcium metabolic signals contribute melanoma invasiveness; however, underlying molecular details are elusive.The MCU complex major route for calcium into mitochondrial matrix but whether affects pathobiology was not understood.Here, we show that A expression correlates with patient survival decreased in BRAF kinase inhibitor-resistant melanomas.Knockdown (KD) suppresses cell growth stimulates...
Store-operated calcium entry (SOCE) through STIM-gated ORAI channels governs vital cellular functions. In this context, SOCE controls redox signaling and is itself regulated by modifications. However, the molecular mechanisms underlying calcium-redox interplay functional outcomes are not fully understood. Here, we examine role of STIM2 in regulation. Redox proteomics identify cysteine 313 as main sensor vitro vivo. Oxidative stress suppresses currents cells overexpressing ORAI1, an effect...
Melanoma, the deadliest of skin cancers, has a high propensity to form brain metastases that are associated with markedly worsened prognosis. In spite recent therapeutic advances, melanoma lesions remain clinical challenge, biomarkers predicting dissemination not clear and differences other metastatic sites poorly understood.We examined genetically diverse panel human-derived metastasis (MBM) extracranial cell lines using targeted sequencing, Reverse Phase Protein Array, protein expression...
The concept of ultrasonic 3D caging is based in wells designed to host three orthogonal half-wave acoustic resonances defined by its dimensions generating a single-pressure-node the center where particles collect aggregate. A replacement planar shapes these cavities curved walls introduce changes pressure patterns, different effects on exposed field. Here we present an experimental study behavior aqueous suspensions micron-sized polystyrene (Cv~1%) ultrasounds at frequency f~1MHz metal...