A5091876857- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- Pregnancy and preeclampsia studies
- Muscle Physiology and Disorders
- Air Quality and Health Impacts
- Radiomics and Machine Learning in Medical Imaging
- Chronic Myeloid Leukemia Treatments
- Advanced Neuroimaging Techniques and Applications
- Acute Kidney Injury Research
- Macrophage Migration Inhibitory Factor
- Monoclonal and Polyclonal Antibodies Research
- Effects of Radiation Exposure
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Disorders and Syndromes
- Exercise and Physiological Responses
- Disaster Response and Management
- PI3K/AKT/mTOR signaling in cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- ATP Synthase and ATPases Research
- Peripheral Nerve Disorders
- Pomegranate: compositions and health benefits
- Occupational and environmental lung diseases
Union Hospital
2018-2024
Jilin University
2018-2024
Union Hospital
2024
Nanjing Medical University
2020-2023
Jiangsu Province Hospital
2020-2023
China South Industries Group (China)
2019-2021
Skeletal muscle atrophy with high prevalence can induce weakness and fatigability place huge burden on both health quality of life. During skeletal degeneration, excessive fibroblasts extracellular matrix (ECM) accumulated to replace impair the resident fiber led loss mass. Cyclooxygenase-2 (COX-2), rate-limiting enzyme in synthesis prostaglandin, has been identified as a positive regulator pathophysiological process like inflammation oxidative stress. In our study, we found injured muscles...
Abstract Lung cancer is a noxious disease with substandard overall survival. Despite this, there are several treatment strategies for lung include chemotherapy, radiotherapy, surgery; however, the survival remains poor. Punicalagin has been documented as potential phytomedicine to selectively inhibit progression and expansion of numerous cancers. In present study, we evaluated antiproliferative ability punicalagin against A549 cells by inducing apoptosis inhibiting STAT‐3 activation. induces...
Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor long-term outcomes. Numerous studies claim that circular RNAs (circRNAs) are important regulators in AML progression. This study intended to explore the role of circNPM1 development and drug chemoresistance. The expression miR-345-5p was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Cellular activities, including cell growth, apoptosis, cycle, migration invasion, were monitored using...
Accumulating evidence has indicated that abnormal microRNAs (miRNAs) serve critical roles in carcinogenesis and development of osteosarcoma (OS). The purpose the present study was to elucidate relationship between miR-766-3p explore potential mechanism. In this study, we found most downregulated miRNA by analyzing GSE65071 from GEO database. lowly expressed OS tissue samples cells, high expression repressed malignant level OS, including cell proliferation, EMT, migration, invasion vitro...
To elaborate the significance of combined detection cystatin C, urinary micro-albumin (mAlb) and β2-microglobulin (β2-MG) in diagnosis early renal injury pregnancy-induced hypertension syndrome.A total 120 patients with syndrome who were admitted to this hospital for treatment between November 2015 October 2018 enrolled as subjects, divided into control group (without complication injury, n = 76) observation (with 44) according complications injury. Furthermore, 60 participated antenatal...
Summary Imatinib mesylate (IM) resistance has become a major clinical problem for chronic myeloid leukaemia (CML). It is known that Bcl‐x splicing deregulated and involved in multiple malignant cancer initiation chemotherapy resistance, including CML. The aim of the present study was to correct abnormal CML investigate subsequent phenotype changes, especially response IM. aberrant cells effectively restored using vivo‐Morpholino Antisense Oligomer (vMO). CCK‐8 cell viability assay flow...
Abstract Polycyclic aromatic hydrocarbons (PAHs) are the most common contaminants in air pollutants. Inhalation exposure to PAHs could increase risk of respiratory disease, cardiovascular disease and even cancer. However, biotoxicity multi‐component from atmospheric pollutants has been poorly studies. The main topic this study was investigate mixture, which derived pollutants, induced toxic effects inflammatory on human bronchial epithelial cells vitro. results showed that mixture decrease...
Blast lung injury (BLI) is the major cause of death in explosion-derived shock waves; however, mechanisms BLI are not well understood. To identify time-dependent manner BLI, a model rats induced by waves was established fuel air explosive. The evaluated hematoxylin and eosin staining pathological score. inflammation oxidative stress were also investigated. scores rats’ at 2 h, 24 3 days, 7 days post-blast 9.75±2.96, 13.00±1.85, 8.50±1.51, 4.00±1.41, respectively, which significantly...
Excessive radiation exposure may lead to edema of the spinal cord and deterioration nervous system. Magnetic resonance imaging can be used judge assess extent evaluate pathological changes thus for evaluation injuries caused by therapy. Radioactive 125I seeds irradiate 90% tissue at doses 40-100 Gy (D90) were implanted in rabbits T10 induce injury, we evaluated their safety use cord. Diffusion tensor showed that with increased D90, apparent diffusion coefficient fractional anisotropy values...
Abstract Background There is insufficient data on severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2) infection in Chinese patients with multiple sclerosis (pwMS). This study aims to explore the manifestation of pwMS during Coronavirus disease 2019 (COVID-19) pandemic and effect SARS-CoV-2 prognosis MS northern China. Methods In this cross-sectional study, an online self-administered questionnaire telephone interviews were conducted among Clinical correlation since onset...
Aim This study aimed to analyze the differences in radiomic features of anterior scalene muscle and evaluate diagnostic performance MRI-based radiomics model for neurogenic thoracic outlet syndrome (NTOS). Materials Methods Imaging data patients with NTOS who underwent preoperative brachial plexus magnetic resonance neurography were collected randomly divided into training test groups. The area was sliced T1WI sequence as region interest extraction features. most significant identified using...
Abstract Background Emerging evidence has indicated that abnormal microRNAs (miRNAs) play critical roles in carcinogenesis and progression of osteosarcoma (OS). The aim this study was to clarify the relationship between miR-766-3p expression development explore its potential mechanism. Methods most downregulated miRNA by analyzing GSE65071 from GEO database. RT-PCR western blot performed determine specific target gene human OS samples cell lines. CCK-8 proliferation, colony formation, EdU,...