A5071830954- Trace Elements in Health
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Heavy Metal Exposure and Toxicity
- Plant Micronutrient Interactions and Effects
- Nutrition and Health in Aging
- Drug Transport and Resistance Mechanisms
- Muscle Physiology and Disorders
- Endoplasmic Reticulum Stress and Disease
- Metabolism and Genetic Disorders
- Genetic Neurodegenerative Diseases
- Pancreatic function and diabetes
- Folate and B Vitamins Research
- Sirtuins and Resveratrol in Medicine
- Atherosclerosis and Cardiovascular Diseases
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Climate Change and Health Impacts
- Nuclear Structure and Function
- Mitochondrial Function and Pathology
- Air Quality and Health Impacts
- Muscle metabolism and nutrition
- Biochemical Analysis and Sensing Techniques
- Tea Polyphenols and Effects
University of Florida
2014-2024
University of California, Berkeley
1996-2008
Western Human Nutrition Research Center
2008
Universidade Federal do Rio de Janeiro
2008
Nutrition Sciences (Belgium)
2006
University of California, Los Angeles
2005
Harvard University
2000-2004
Murphy Oil Corporation (United States)
2003
Rafsanjan University of Medical Sciences
2003
The University of Texas Health Science Center at San Antonio
2003
Infection and inflammation produce systemic responses that include hypozincemia hypoferremia. The latter involves regulation of the iron transporter ferroportin 1 by hepcidin. mechanism reduced plasma zinc is not known. Transcripts two gene families ( ZnT Zip ) were screened for in mouse liver after turpentine-induced LPS administration. Zip14 mRNA was transcript most up-regulated LPS. IL-6 knockout (IL-6 –/– mice did exhibit either or induction with turpentine inflammation. However, mice,...
Zip14 is a member of the SLC39A zinc transporter family, which involved in uptake by cells. Up-regulation IL-6 appears to contribute hepatic accumulation and hypozincemia inflammation. At least three members family transport other trace elements, such as iron manganese, addition zinc. We analyzed capability mediate non-transferrin-bound (NTBI) overexpressing mouse HEK 293H cells Sf9 insect was found localize plasma membrane, its overexpression increased both 65 Zn 59 Fe. Addition...
Ferroportin 1 (FPN1) is transmembrane protein involved in iron homeostasis. In the duodenum, FPN1 localizes to basolateral surface of enterocytes where it appears export out cell and into portal circulation. also abundantly expressed reticuloendothelial macrophages liver, spleen, bone marrow, suggesting that this serves as an exporter cells recycle from senescent red blood cells. To directly test hypothesis functions after erythrophagocytosis, was stably J774 mouse by using retroviral...
Approximately two billion people, mainly women and children, are iron deficient. Two studies examined the effects of deficiency supplementation on rats. In study 1, mitochondrial functional parameters DNA (mtDNA) damage were assayed in iron-deficient (≤5 μg/day) iron-normal (800 rats both groups after daily high-iron (8,000 for 34 days. This dose is equivalent to commonly given humans. Iron-deficient had lower liver respiratory control ratios increased levels oxidants...
Recent studies have shown that overexpression of the transmembrane protein Zrt- and Irt-like 14 (Zip14) stimulates cellular uptake zinc nontransferrin-bound iron (NTBI). Here, we directly tested hypothesis Zip14 transports free zinc, iron, other metal ions by using Xenopus laevis oocyte heterologous expression system, use this approach also allowed us to characterize functional properties Zip14. Expression mouse in RNA-injected oocytes stimulated (55)Fe presence l-ascorbate but not...
The liver, pancreas, and heart are particularly susceptible to iron-related disorders. These tissues take up plasma iron from transferrin or non-transferrin-bound iron, which appears during overload. Here, we assessed the effect of status on levels transmembrane transporters, ZRT/IRT-like protein 14 divalent metal-ion transporter-1, have both been implicated in transferrin- uptake. Weanling male rats (n=6/group) were fed an iron-deficient, iron-adequate, iron-overloaded diet for 3 weeks. 14,...
SIRT2 is a cytoplasmic sirtuin that plays role in various cellular processes, including tumorigenesis, metabolism, and inflammation. Since these processes require iron, we hypothesized directly regulates iron homeostasis. Here, have demonstrated depletion results decrease levels both vitro vivo. Mechanistically, determined maintains by binding to deacetylating nuclear factor erythroid-derived 2-related 2 (NRF2) on lysines 506 508, leading reduction total NRF2 levels. The leads reduced...
Solute carrier family 39, member 14 (SLC39A14) is a transmembrane transporter that can mediate the cellular uptake of zinc, iron, and manganese (Mn). Studies Slc39a14 knockout (Slc39a14-/-) mice have documented SLC39A14 required for systemic growth, hepatic zinc during inflammation, iron loading liver in overload. The normal physiological roles SLC39A14, however, remain incompletely characterized. Here, we report Slc39a14-/- spontaneously display dramatic alterations tissue Mn...