A5078144010- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- DNA Repair Mechanisms
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Cyclopropane Reaction Mechanisms
- Muscle Physiology and Disorders
- Catalytic C–H Functionalization Methods
- Nutrition and Health in Aging
- Catalytic Cross-Coupling Reactions
- Chromatin Remodeling and Cancer
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Oxidative Organic Chemistry Reactions
- Vanadium and Halogenation Chemistry
- Malaria Research and Control
- Ethnobotanical and Medicinal Plants Studies
- DNA and Nucleic Acid Chemistry
- PARP inhibition in cancer therapy
- Trace Elements in Health
- GDF15 and Related Biomarkers
- Synthesis and Catalytic Reactions
- Synthesis of Indole Derivatives
Cancer Genetics (United States)
2018-2022
Columbia University
2017-2022
Women's College Hospital
2021
Columbia University Irving Medical Center
2017-2020
The University of Texas MD Anderson Cancer Center
2010-2019
National Center on Addiction and Substance Abuse at Columbia University
2018
Nanyang Technological University
2014-2015
Mahindra University
2015
Analytisches Laboratorium
2014
University of Münster
2011-2014
This Concept article discusses the potential of oxidative carbene catalysis in synthesis and comprehensively covers pioneering studies as well recent developments. Oxidative can be conducted by using inorganic organic oxidants. Applications cascade processes, enantioselective catalysis, also natural product are discussed.
The retinoblastoma (RB) tumor suppressor is recognized as a master regulator that controls entry into the S phase of cell cycle. Its loss leads to uncontrolled proliferation and hallmark cancer. RB works by binding members E2F family transcription factors recruiting chromatin modifiers promoters target genes. Here we show also localizes DNA double-strand breaks (DSBs) dependent on E2F1 ATM kinase activity promotes DSB repair through homologous recombination (HR), its results in genome...
A method for synthesis of 3-azabicyclo[3.1.0]hex-2-enes has been developed by intramolecular cyclopropanation readily available N-allyl enamine carboxylates. Two complementary reaction conditions, CuBr-mediated aerobic and CuBr2-catalyzed-PhIO2-mediated systems effectively induced stepwise via carbocupration alkenes. Oxidative cyclopropane ring-opening 5-substituted was also highly substituted pyridines. In addition, diastereoselective reduction to 3-azabicyclo[3.1.0]hexanes achieved using...
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) osimertinib has significantly prolonged progression-free survival (PFS) in patients with EGFR-mutant lung cancer, including those brain metastases. However, despite striking initial responses, osimertinib-treated eventually develop lethal metastatic relapse, often to the brain. Although osimertinib-refractory relapse is a major clinical challenge, its underlying mechanisms remain poorly understood. Using models of we...
Three stereocenters are formed in the carbene catalyzed cascade reaction of enals with various β-diketones to give corresponding indane derivatives excellent stereoselectivities. The products readily transformed 1,2,3-trisubstituted derivatives, which represent privileged substructures medicinal chemistry.
Carbene catalysed redox activation of α,β-unsaturated aldehydes is applied for generation acyl azoliums which undergo cyclopropanation upon reaction with a sulfur ylide and an alcohol to give the corresponding cyclopropanecarboxylic acid esters. With chiral carbenes good excellent diastereo enantioselectivities are obtained.
Abstract Cu 0 nanoparticles were deposited on a nanoporous polymer to develop novel nanocatalyst (Cu-B) for carrying out Ullmann coupling of aryl halides with amines in water. Non-aqueous polymerization mixture divinylbenzene and acrylic acid under hydrothermal conditions followed by the deposition adopted afford Cu-B nanocatalyst. In order compare catalytic activity reactions, another nanocatalyst, nanoparticle-loaded porous carbon (Cu-A), was also prepared. All newly developed...
Abstract E2F1 and retinoblastoma (RB) tumor-suppressor protein not only regulate the periodic expression of genes important for cell proliferation, but also localize to DNA double-strand breaks (DSBs) promote repair. is acetylated in response damage role this plays repair unknown. Here we demonstrate that acetylation creates a binding motif bromodomains p300/KAT3B CBP/KAT3A acetyltransferases interaction required recruitment p300 CBP DSBs induction histone at sites damage. A knock-in...
The ability of Plasmodium falciparum-infected red blood cells (IRBCs) to bind vascular endothelium, thus enabling sequestration in vital host organs, is an important pathogenic mechanism malaria. Adhesion P. falciparum IRBCs platelets, which results the formation IRBC clumps, another cytoadherence phenomenon that associated with severe disease. Here, we have used vitro assays demonstrate, our knowledge for first time, use 32-kDa human protein gC1qR/HABP1/p32 as a receptor brain microvascular...
The E2F1 transcription factor is post-translationally modified and stabilized in response to various forms of DNA damage regulate the expression cell cycle pro-apoptotic genes. also foci at double-strand breaks (DSBs) but function sites unknown. Here we demonstrate that absence leads spontaneous impaired recovery following exposure ionizing radiation. deficiency results defective NBS1 phosphorylation formation DSBs does not affect levels. Moreover, an increased association between observed...
Pyrazolidinones with a tetrahydroisoquinoline core are obtained excellent diastereocontrol and high enantioselectivity. Theoretical studies give insight on the reaction mechanism.
Abstract Isothiourea was first employed as catalyst by Birman in 2006 for the enantioselective acyl transfer reaction. The then well explored course of kinetic resolution and desymmetrization studies. A few years later, Romo Smith applied isothiourea catalysis cascade reactions to prepare carbocycles heterocycles acessing new reactivities isothiourea. Several research groups were attracted toward this field organocatalysis, isothioureas nucleophilic catalysts executing methodologies...
Introduction: Disease pattern as well diagnostic and treatment options may be helped by examining the diameter of parietal cells human stomach, change with age. It seems that there is a few research in this area needs more studies, including gross anatomical data available Bangladesh. Materials Methods: This Cross-sectional descriptive study was carried out at Department anatomy, Sylhet M.A.G. Osmani Medical College, during periods from January 2013 to December 2013. Fifty postmortem stomach...
The E2F1 transcription factor is a well known regulator of cell proliferation and apoptosis, but its role in the DNA damage response less clear. Using local UV irradiation technique immunofluorescence staining, shown to accumulate at sites damage. Localization UV-damaged requires ATM Rad3-related (ATR) kinase serine 31 not an intact binding domain. deficiency does appear affect expression nucleotide excision repair (NER) factors, such as XPC XPA. However, depletion impair recruitment NER...
Neolamarckia cadamba (Rubiaceae) leaf is used in folk medicine of Bangladesh for the treatment diabetes, but so far no scientific study has been done which may support its use traditional medicine. The present was carried out to evaluate possible glucose tolerance efficacy methanolic extract using glucose-induced hyperglycemic mice. at different doses administered one hour prior administration and blood level measured after two hours (p.o.) oxidase method. statistical data indicated...
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer type in which the mortality rate approaches incidence rate. More than 85% of PDAC patients experience profound loss muscle mass and function, known as cachexia. with this condition suffer from decreased tolerance to anti-cancer therapies often succumb premature death due respiratory cardiac wasting. Yet, there are no approved available alleviate We previously found that upregulation metal ion transporter, Zip14, altered zinc...
Abstract The Pictet‐Spengler reaction is a century old technique for the construction of aza‐cycles, which has been extensively researched through organocatalytic methods over past two decades. asymmetric variant this gained considerable attention because enantioenriched poly heterocycles accessed process are prevalent in natural products and bioactive moleculesPrime focus review systematic chronological assembly enantioselective P−S catalyzed by different types organocatalysts. Mechanistic...
Cancer is a life-threatening disease that has plagued humans for centuries. The vast majority of cancer-related mortality results from metastasis. Indeed, the invasive growth metastatic cancer cells in vital organs causes fatal organ dysfunction, but metastasis-related deaths also result cachexia, debilitating wasting syndrome characterized by an involuntary loss skeletal muscle mass and function. In fact, about 80% patients suffer which often renders them too weak to tolerate standard doses...