A5008671795- SARS-CoV-2 and COVID-19 Research
- Photoreceptor and optogenetics research
- Photosynthetic Processes and Mechanisms
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Spectroscopy and Quantum Chemical Studies
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Electrochemical sensors and biosensors
- Mosquito-borne diseases and control
- Hemoglobin structure and function
- Animal Virus Infections Studies
- RNA regulation and disease
- bioluminescence and chemiluminescence research
- Viral Infections and Immunology Research
- Protein Interaction Studies and Fluorescence Analysis
- COVID-19 Impact on Reproduction
- Malaria Research and Control
- Viral gastroenteritis research and epidemiology
- Electrochemical Analysis and Applications
- Immunotherapy and Immune Responses
Consejo Nacional de Investigaciones Científicas y Técnicas
2021-2024
Fundación Instituto Leloir
2021-2024
Fundación Ciencias Exactas y Naturales
2015-2021
University of Buenos Aires
2015-2021
Instituto de Química y Fisicoquímica Biológicas
2021
Institute of Astronomy and Space Physics
2015-2019
Massive vaccination offers great promise for halting the global COVID-19 pandemic. However, limited supply and uneven vaccine distribution create an urgent need to optimize strategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V of healthcare workers in Argentina, measuring IgG anti-spike titers neutralizing capacity one two doses a cohort naive or previously infected volunteers. By 21 days receiving first dose vaccine, 94% participants develop spike-specific...
Heterologous vaccination against coronavirus disease 2019 (COVID-19) provides a rational strategy to rapidly increase coverage in many regions of the world. Although data regarding messenger RNA (mRNA) and ChAdOx1 vaccine combinations are available, there is limited information about combination these platforms with other vaccines widely used developing countries, such as BBIBP-CorV Sputnik V. Here, we assess immunogenicity reactogenicity 15 1,314 participants. We evaluate immunoglobulin G...
We report a resonance Raman and UV-vis characterization of the active site structure oxidatively modified forms cytochrome c (Cyt-c) free in solution complexes with cardiolipin (CL). The studied post-translational modifications Cyt-c include methionine sulfoxidation tyrosine nitration, which lead to altered heme axial ligation increased peroxidase activity respect those wild-type protein. In spite structural differences between protein variants solution, binding CL liposomes induces all...
Vaccines have been produced in record time for SARS-CoV-2, offering the possibility of halting global pandemic. However, inequalities vaccine accessibility different regions world create a need to increase international cooperation.
Dengue virus (DENV) is the most important human transmitted by mosquitos. pathogenesis characterized a large induction of proinflammatory cytokines. This cytokine varies among four DENV serotypes (DENV1 to 4) and poses challenge for live vaccine design. Here, we identify viral mechanism limit NF-κB activation secretion protein NS5. Using proteomics, found that NS5 binds degrades host ERC1 antagonize activation, secretion, reduce cell migration. We degradation involves unique properties...
Abstract Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that causes severe outbreaks in human populations. ZIKV infection leads to the accumulation of small non-coding viral RNAs (known as sfRNAs) are crucial for evasion antiviral responses and pathogenesis. However, mechanistic understanding how sfRNAs function remains incomplete. Here, we use recombinant ZIKVs ribosome profiling infected cells show block translation genes. Mechanistically, demonstrate specific RNA structures...
Background Recent studies have shown the presence of SARS-CoV-2-specific antibodies in milk breastfeeding mothers vaccinated with mRNA and convalescent. However, limited information is available lactating women receiving other vaccine platforms used developing countries, such as inactivated SARS-CoV-2 BBIBP-CorV (Sinopharm) non-replicating adenovirus vaccines Sputnik V (Gamaleya Institute) ChAdOx1-S (Oxford AstraZeneca). Methods Here, we evaluated anti-SARS-CoV-2 IgG IgA levels both serum...
ABSTRACT Recent studies have shown a temporal increase in the neutralizing antibody potency and breadth to SARS-CoV-2 variants coronavirus disease 2019 (COVID-19) convalescent individuals. Here, we examined longitudinal responses viral capacity B.1 lineage virus (Wuhan related), of concern (VOCs: Alpha, Beta, Gamma, Delta) local variant interest (VOI: Lambda) volunteers receiving Sputnik V vaccine Argentina. A collection 472 serum samples obtained between January September 2021 was used. The...