Lautaro Sánchez
A5083085541- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Viral Infections and Immunology Research
- RNA Interference and Gene Delivery
- COVID-19 Impact on Reproduction
- Bacillus and Francisella bacterial research
Fundación Instituto Leloir
2020-2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2020-2022
University of Buenos Aires
2022
Instituto de Investigaciones Biomédicas en Retrovirus y Sida
2022
Massive vaccination offers great promise for halting the global COVID-19 pandemic. However, limited supply and uneven vaccine distribution create an urgent need to optimize strategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V of healthcare workers in Argentina, measuring IgG anti-spike titers neutralizing capacity one two doses a cohort naive or previously infected volunteers. By 21 days receiving first dose vaccine, 94% participants develop spike-specific...
We report the emergency development and application of a robust serologic test to evaluate acute convalescent antibody responses SARS-CoV-2 in Argentina. The assays, COVIDAR IgG IgM, which were produced provided for free health authorities, private public institutions nursing homes, use combination trimer stabilized spike protein receptor binding domain (RBD) single enzyme-linked immunosorbent assay (ELISA) plate. Over half million tests have already been distributed detect quantify...
Heterologous vaccination against coronavirus disease 2019 (COVID-19) provides a rational strategy to rapidly increase coverage in many regions of the world. Although data regarding messenger RNA (mRNA) and ChAdOx1 vaccine combinations are available, there is limited information about combination these platforms with other vaccines widely used developing countries, such as BBIBP-CorV Sputnik V. Here, we assess immunogenicity reactogenicity 15 1,314 participants. We evaluate immunoglobulin G...
Vaccines have been produced in record time for SARS-CoV-2, offering the possibility of halting global pandemic. However, inequalities vaccine accessibility different regions world create a need to increase international cooperation.
Background Recent studies have shown the presence of SARS-CoV-2-specific antibodies in milk breastfeeding mothers vaccinated with mRNA and convalescent. However, limited information is available lactating women receiving other vaccine platforms used developing countries, such as inactivated SARS-CoV-2 BBIBP-CorV (Sinopharm) non-replicating adenovirus vaccines Sputnik V (Gamaleya Institute) ChAdOx1-S (Oxford AstraZeneca). Methods Here, we evaluated anti-SARS-CoV-2 IgG IgA levels both serum...
Abstract Human immunodeficiency virus (HIV) neuroinvasion occurs early after infection through the trafficking of virus‐infected immune cells into central nervous system (CNS) and viral dissemination brain. There, it can infect resident brain including astrocytes, most abundant cell type that is crucial to homeostasis. In this report, we examined HIV‐related mechanism able induce bystander death in astrocytes mediated by cell‐to‐cell contact with productively infected (PI) ones. We first...
ABSTRACT Recent studies have shown a temporal increase in the neutralizing antibody potency and breadth to SARS-CoV-2 variants coronavirus disease 2019 (COVID-19) convalescent individuals. Here, we examined longitudinal responses viral capacity B.1 lineage virus (Wuhan related), of concern (VOCs: Alpha, Beta, Gamma, Delta) local variant interest (VOI: Lambda) volunteers receiving Sputnik V vaccine Argentina. A collection 472 serum samples obtained between January September 2021 was used. The...
ABSTRACT We report the emergency development and application of a robust serologic test to evaluate acute convalescent antibody responses SARS-CoV-2 in Argentina. The assays, COVIDAR IgG IgM, which were produced provided for free health authorities, private public institutions nursing homes, use combination trimer stabilized spike protein receptor binding domain (RBD) single enzyme-linked immunosorbent assay (ELISA) plate. Over half million tests have already been distributed detect quantify...