A5078598590- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Colorectal Cancer Surgical Treatments
- Clinical practice guidelines implementation
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Gastroesophageal reflux and treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Eosinophilic Esophagitis
- Radiomics and Machine Learning in Medical Imaging
- Advances in Oncology and Radiotherapy
- Medical Imaging Techniques and Applications
- Multiple and Secondary Primary Cancers
- Cancer-related Molecular Pathways
- Neutropenia and Cancer Infections
Mount Sinai Health System
2023-2024
The University of Melbourne
2005-2022
The Royal Melbourne Hospital
1977-2022
Public Health Wales
2022
Department of Health and Human Services
2018-2021
Thomas Jefferson University
2020
Government of Victoria
2018-2019
Cancer Council Victoria
2002-2018
Victorian Comprehensive Cancer Centre
2018
Peter MacCallum Cancer Centre
2000-2011
Greater understanding of international cancer survival differences is needed. We aimed to identify predictors and consequences diagnosis through emergency presentation in different jurisdictions six high-income countries.
Activation of beta-catenin/T cell factor (TCF) transcription as a result mutations in the adenomatous polyposis coli (APC) and/or beta-catenin genes occurs majority colon tumors. An increasing number genes, including c-myc and cyclin D1, have been implicated targets this pathway. We now report that dominant negative helix-loop-helix regulator Id2 is also target beta-catenin/TCF pathway adenocarcinoma. Investigation mechanism for overexpression carcinoma cells demonstrated promoter activated,...
Abstract Background: Longer cancer pathways may contribute to rural–urban survival disparities, but research in this area is lacking. We investigated time diagnosis and treatment for rural urban patients with colorectal or breast Victoria, Australia. Methods: Population-based surveys (2013–2014) of (aged ≥40, approached within 6 months diagnosis), primary care physicians (PCPs), specialists were collected as part the International Cancer Benchmarking Partnership, Module 4. Six intervals...
Adenocarcinomas of the oesophagus and gastric cardia have been reported to be increasing in incidence many countries, while squamous cell carcinoma is stable non‐cardia cancers are decreasing incidence. Age‐standardized rates for years 1982–93 oesophageal adenocarcinoma non‐adenocarcinoma, were calculated based on state cancer registry data. Time trends age‐standardized assessed using linear regression. A consistent trend men was seen all states Australia statistically significant except...
Esophageal cancer is a particularly aggressive tumor with poor prognosis, however, our current knowledge of the genes and pathways involved in tumorigenesis esophagus are limited. To obtain insight into molecular processes underlying esophagus, we have used cDNA microarrays to compare gene expression profiles 128 tissue samples representing major histological subtypes esophageal (squamous cell carcinoma adenocarcinoma (ADC)) as well Barrett's (BE), precursor lesion ADC, normal epithelium....
Abstract The identification and characterization of esophageal stem cells are critical to our understanding the biology epithelium in health disease. However, proliferative compartment within mouse remains poorly characterized. Here, we report that basal esophagus can be separated into three phenotypically functionally distinct subpopulations based on expression α6 integrin transferrin receptor (CD71). Cells express high levels low CD71, termed α6briCD71dim, a minor subpopulation small...
Phosphatidylinositol 3-kinase (PI 3-kinase), an enzyme that phosphorylates inositol phospholipids at the D-3 position of ring, has been implicated in signaling pathways regulating cell growth by virtue its activation response to various mitogenic stimuli. In spite considerable attention PI received with regard possible role hematopoietic malignancies, there are few reports investigations into activity solid tumors.Colorectal tumor tissue and normal-appearing colonic mucosa from same patients...
Mutation of PIK3CA, the gene coding for p110alpha catalytic subunit phosphoinositide 3-kinase (PI3K), has been reported in a limited range human tumors. We now report that PIK3CA is also mutated esophageal Single-strand conformational polymorphism (SSCP) and denaturing high-performance liquid chromatography (DHPLC) were used to screen all 20 exons 101 samples from 95 individuals with cancer and/or Barrett's esophagus. Somatic mutation was detected 4 35 (11.8%) squamous cell carcinomas (SCC)...
Abstract Purpose: Patients presenting with locally advanced rectal cancer currently receive preoperative radiotherapy or without chemotherapy. Although pathologic complete response is achieved for approximately 10% to 30% of patients, a proportion patients derive no benefit from this therapy while being exposed toxic side effects treatment. Therefore, there strong need identify who are unlikely neoadjuvant help direct them toward alternate and ultimately more successful treatment options....
There is clinical evidence that adenocarcinoma of the lower oesophagus increasing in Australian society. The population-based cancer registry Victoria was used to describe incidence and gastric cardia.Data were obtained from 1982 1991 analysed using Poisson regression techniques.In men, a statistically significant annual increase 9.5% oesophageal non-significant 1.6% cardia observed. These increases balanced by decreases other histological types found men resulting little change overall...
Objective To document self-reported beliefs and behaviours in relation to colorectal cancer (CRC) screening for CRC. Data collection A stratified random sample was selected from the telephone directory, structured interviews were conducted using a computer assisted interviewing system. Participants 500 men women aged 40-S0 years, 70% randomly Melbourne metropolitan area 30% rural Victoria. The response rate initial invitation of 1569 eligible people 63. 7%. Outcome measures Awareness...
A prospective controlled study of the safety various catheter dressing protocols was carried out in 168 patients receiving parenteral nutrition via an infraclavicular central venous catheter. Four were compared: 36 received gauze dressings changed three times per week; 31 OpSite every 7th day (OpS‐7), 32 10th (OpS‐10), and 69 twice weekly (OpS‐ICU). Mean duration approximately 2 weeks all groups well matched except that OpS‐ICU suffered more frequently from acute illness. Catheter‐related...
To improve cancer outcomes for Aboriginal and Torres Strait Islander people through the development national endorsement of first population-specific optimal care pathway (OCP) to guide delivery high-quality, culturally appropriate, evidence-based care.
Locally advanced oesophageal cancer (LAEC) is associated with poor survival and more effective treatments are needed. The aim of this phase I trial was to assess the maximum tolerated dose (MTD) a novel weekly docetaxel cisplatin regimen concurrent radical radiotherapy. Patients unresectable, non-metastatic LAEC were eligible. Treatment comprised 15–30 mg m−2 per week in six planned levels (DLs) 3–6 patient cohorts 50 Gy radiotherapy 25 fractions. Maximum based on defined dose-limiting...