A5005939079- Streptococcal Infections and Treatments
- Synthesis and biological activity
- Neonatal and Maternal Infections
- Immunotherapy and Immune Responses
- Synthesis and Characterization of Heterocyclic Compounds
- RNA Interference and Gene Delivery
- Multicomponent Synthesis of Heterocycles
- Antimicrobial Peptides and Activities
- vaccines and immunoinformatics approaches
- Malaria Research and Control
- Parasites and Host Interactions
- Chemical Synthesis and Reactions
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Ionic liquids properties and applications
- Mosquito-borne diseases and control
- Synthesis of heterocyclic compounds
- Synthesis of Organic Compounds
- Radical Photochemical Reactions
- Chemical Reaction Mechanisms
- Helminth infection and control
- Parasite Biology and Host Interactions
- Kawasaki Disease and Coronary Complications
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
Griffith University
2021-2023
National Institute on Drug Abuse
2023
The University of Queensland
2017-2022
Sinhgad Dental College and Hospital
2015
Hindu College of Pharmacy
2014
Swami Vivekanand College of Pharmacy
2014
To be optimally effective, peptide-based vaccines need to administered with adjuvants. Many currently available adjuvants are toxic, not biodegradable; they invariably invoke adverse reactions, including allergic responses and excessive inflammation. A nontoxic, biodegradable, biocompatible, self-adjuvanting vaccine delivery system is urgently needed. Herein, we report a potent fulfilling the above requirements. peptide antigen was coupled poly-hydrophobic amino acid sequences serving as...
Abstract Background The human hookworm, Necator americanus, is a parasite that infects almost half billion people worldwide. Although treatment available, vaccination favorable to combat the spread of this due its wide distribution and continuous reinfection cycle in endemic communities. Methods We have designed lipopeptide oral delivery system using B-cell epitope derived from aspartic protease Na-APR-1 N attached T-helper epitope. Lipopeptides were self-assembled into nanoparticles or...
Peptide-based subunit vaccines require an immunostimulant (adjuvant) and/or delivery system to protect the antigenic peptide from degradation and induce desired immunity. Currently available adjuvants are either too toxic for human use (experimental adjuvants) or they limited in particular licensed countries (commercial adjuvants). Therefore, there is immediate need novel that both safe effective. Herein, we assessed ability of cholic acid (a major bile acid) as a nontoxic, biodegradable,...
Infection with malaria parasites continues to be a major global public health issue. While current control measures have enabled significant decrease in morbidity and mortality over the last 20 years, additional tools will required if we are progress toward parasite eradication. Malaria vaccine research has focused on development of subunit vaccines; however, more recently, interest whole-parasite vaccines reignited. Whole-parasite enable presentation broad repertoire antigens immune system,...
Peptide-based vaccines have been proposed as a therapeutic strategy for many infectious diseases, including human papilloma virus (HPV)-related cervical cancer. are better treatment option than traditional chemotherapeutic agents and surgery, they rely on the use of body’s immune system to fight cancer cells, resulting in minimal risk side effects. However, increase efficacy peptide-based vaccines, application potent adjuvant suitable delivery is essential. In this study, we developed...
Introduction: Despite decades of research into the development a vaccine to combat malaria parasite, highly efficacious is not yet available. Different whole parasite-based approaches, including deliberate Plasmodium infection and drug cure (IDC), have been evaluated in pre-clinical early phase clinical trials. The advantage parasite vaccines that they induce immune responses against multiple antigens, thus lowering impact antigenic diversity. Deliberate IDC, as approach, involves...
Peptide-based vaccines are composed of minimal microbial components that required to stimulate immune responses. Peptide antigens easy produce, relatively cheap and non-toxic. They also able activate the system in a well-controlled manner. However, peptides themselves poor immunogens have be co-administered with an adjuvant (immune stimulator) produce desired Unfortunately, many adjuvants toxic, poorly effective or not compatible peptide antigens. Recently, we demonstrated that, upon...
Malaria is a devastating disease that has claimed many lives, especially children <5 years of age in Sub-Saharan Africa, as documented World Reports by WHO. Even though vector control and chemoprevention tools have helped with elimination efforts some, if not all, endemic areas, these been hampered serious issues (including drug insecticide resistance disruption to social cohesion caused the COVID-19 pandemic). Development an effective malaria vaccine alternative preventative tool fight...
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Abstract Review: [125 refs.