A5090099675- FOXO transcription factor regulation
- Sirtuins and Resveratrol in Medicine
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Skin Protection and Aging
- Nanoparticle-Based Drug Delivery
- Wound Healing and Treatments
- melanin and skin pigmentation
- Antimicrobial Peptides and Activities
- PARP inhibition in cancer therapy
- Calcium signaling and nucleotide metabolism
- Immunotherapy and Immune Responses
- Plant Disease Resistance and Genetics
- Alkaloids: synthesis and pharmacology
- Cannabis and Cannabinoid Research
- Essential Oils and Antimicrobial Activity
- Ginger and Zingiberaceae research
- Acute Lymphoblastic Leukemia research
- Tryptophan and brain disorders
- Bee Products Chemical Analysis
- Tea Polyphenols and Effects
- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Antioxidant Activity and Oxidative Stress
- Bioactive Compounds and Antitumor Agents
National Nanotechnology Center
2017-2025
National Science and Technology Development Agency
2017-2025
The University of Queensland
2018-2023
Imperial College London
2012-2016
Hammersmith Hospital
2013-2016
Gold nanoparticles (AuNPs) have been extensively used as nanomaterials for theranostic applications due to their multifunctional characteristics in therapeutics, imaging, and surface modification. In this study, the unique functionalities of exosome-derived membranes were combined with synthetic AuNPs targeted delivery brain cells. Here, we report modification brain-targeted exosomes derived from genetically engineered mammalian cells by using mechanical method or extrusion create these...
In this study, we report the identification of a novel role SIRT6 in both epirubicin and paclitaxel resistance breast cancer. We found that protein levels are elevated paclitaxel- epirubicin-resistant MCF-7 cells compared with parental sensitive cells. knockout depletion sensitized to treatment, whereas ectopic overexpression led increased epirubicin. Moreover, our data suggest could be mediating through enhancing DNA repair response epirubicin-induced damage. Clonogenic assays also revealed...
FOXM1 is implicated in genotoxic drug resistance but its mechanism of action remains elusive. We show here that FOXM1-depletion can sensitize breast cancer cells and mouse embryonic fibroblasts (MEFs) into entering epirubicin-induced senescence, with the loss long-term cell proliferation ability, accumulation γH2AX foci, induction senescence-associated β-galactosidase activity morphology. Conversely, reconstitution FOXM1-deficient MEFs alleviates foci. also demonstrate regulates NBS1 at...
Abstract Biocompatible materials that act as scaffolds for regenerative medicine are of enormous interest. Hydrogel-nanoparticle composites have great potential in this regard, however evaluations their wound healing and safety vivo animal studies scarce. Here we demonstrate a guar gum/curcumin-stabilized silver nanoparticle hydrogel composite is an injectable material with exceptional antibacterial properties. We show the curcumin-bound nanoparticles themselves exhibit low cytotoxicity...
Acanthus spp. have been documented in traditional Thai herbal medicine and are applicable for the treatment of inflamed skin with wound healing property. Nonetheless, scientific evidence necessary to prove herb's doctrine has not yet revealed. Verbascoside-rich extracts A. ebracteatus Vahl., were therefore prepared. The verbascoside examined their abilities using a scratch assay fibroblasts. anti-inflammatory effect suppressing MMP-9 was assessed cocultures keratinocyte (HaCaT cells)...
Abstract Tea ( Camellia spp.) is an important medicinal herb. C. sinensis var. the most studied tea variety due to its more preferred flavor than assamica (Assam tea), less economic importance with bitter variety. A taste highlights potential as a candidate source for catechins, health beneficial actives applicable ageing treatment. Nonetheless, indicative data on UV-induced and senescent remain unclarified. Assam extract (ATE) was prepared standardized in terms of TPC, TFC TTC. EGCG HPLC...
Abstract Sirtuins, NAD + ‐dependent histone deacetylases (HDACs), have recently emerged as potential therapeutic targets for the treatment of a variety diseases. The discovery potent and isoform‐selective inhibitors this enzyme family should provide chemical tools to help determine roles these validate their value. Herein, we report novel class highly selective SIRT2 inhibitors, identified by pharmacophore screening. We identification validation...
The degradation products of crosslinked silk fibroin scaffolds induce distinct macrophage polarization and responses, without causing cytotoxicity or genotoxicity.
Hyperpigmentation is a medical and cosmetic problem caused by an excess accumulation of melanin or the overexpression enzyme tyrosinase, leading to several skin disorders, i.e., freckles, melasma, cancer. Tyrosinase key in melanogenesis thus target for reducing production. Although abalone good source bioactive peptides that have been used properties including depigmentation, available information on anti-tyrosinase property remains insufficient. This study investigated Haliotis diversicolor...
Backgrounds: Cannabidiol (CBD) has been used for the development of extensive cosmeceutical commercial products. However, safety and unclear bioactivity CBD are still concerns need to be examined assess impact on skin cells through applications, particularly its anti-aging wound healing activities. Methods: In our study, cytotoxicity was investigated keratinocytes fibroblasts in short-term long-term treatments using a sulforhodamine B (SRB) assay clonogenic assay, respectively. Next,...
ABSTRACT Cancer stands as a primary contributor to worldwide mortality, especially reproductive‐related cancers (e.g., breast/cervical among females and prostate cancer males). Chemotherapy is the most common systemic therapy for cancer, but its adverse effects are concerning. Developing effective new strategies against necessary increase their efficacy minimize effect. In this work, novel core‐shell structure of lipid nanoparticle (LNP) was fabricated via high‐throughput microfluidic...
This study further investigates the potential of gelatin-based hydrogel cross-linked with vanillin and ferric ion (GVF), combined andrographolide (AGP) silver nanoparticles (AgNPs), as an anti-infection biomaterial for wound dressing, aimed at exploring mechanisms that attenuate inflammation, enhance healing rates, address allergic skin irritation. AGP-AgNPs were evaluated cytotoxicity in human adult epidermal keratinocytes (HEKa) murine macrophage cell line (RAW 264.7), well nitric oxide...
Human papilloma virus (HPV) is responsible for all cases of cervical cancer. While prophylactic vaccines are available, the development peptide-based as a therapeutic strategy still under investigation. In comparison with traditional and currently used treatment strategies chemotherapy surgery, vaccination against HPV promising option fewer side effects. A peptide derived from HPV-16 E7 protein, called 8Qm, in combination adjuvants showed promise vaccine. Here, ability polymerized natural...
Superoxide dismutase (SOD) is an essential enzyme that eliminates harmful reactive oxygen species (ROS) generating inside living cells. Due to its efficacities, SOD widely applied in many applications. In this study, the purification of produced from Saccharomyces cerevisiae TBRC657 was conducted obtain purified exhibited specific activity 513.74 U/mg with a factor 10.36-fold. The inhibitory test revealed classified as Mn-SOD estimated molecular weight 25 kDa on SDS-PAGE. After investigating...
Diabetic Parkinson’s disease (DP) is a progressive neurodegenerative with metabolic syndrome that increasing worldwide. Emerging research suggests cannabidiol (CBD) neuropharmacological compound acts against this disease, especially CBD in nano-formulation. The safety of lipid nanoparticles (CBD-LNP) was evaluated by assessing vitro cytotoxicity neurons and therapeutic outcomes DP animal model, including parameters histopathology. CBD-LNPs were fabricated using microfluidization technique...
Breast cancer is the most common type of malignancies in women worldwide, and genotoxic chemotherapeutic drugs are effective by causing DNA damage cells. However, >90% patients with metastatic resistant to chemotherapy. The Forkhead box M1 (FOXM1) transcription factor plays a pivotal role resistance breast cells chemotherapy promoting repair following drug treatment. aim present study was investigate inhibition FOXM1 protein thiostrepton, natural antibiotic produced Streptomyces species....
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The overpopulation of abandoned and stray companion animals has become a global crisis. main purpose this study was to develop novel nanomedicine-based antifertility compound for non-surgical castration male animals. Mangosteen (Garcinia mangostana L) pericarp extract been shown exhibit anti-fertility property. α-mangostin (AM)-loaded nanostructured lipid carrier (AM-NLC) developed improve germ cell apoptosis. This conducted investigate physicochemical properties AM-NLC determine the...
Abstract Glucocorticoids are widely used to treat B acute lymphoblastic leukemia (B-ALL); however, the molecular mechanism underlying glucocorticoid response and resistance is unclear. In this study, role regulation of FOXO3a in mediating dexamethasone B-ALL were investigated. The results show that mediates cytotoxic function dexamethasone. dexamethasone, it was found translocates into nucleus, where induces expression downstream targets, including p27Kip1 Bim, important for proliferative...
Stress profoundly impacts various aspects of both physical and psychological well-being. Our previous study demonstrated that venlafaxine (Vlx) synbiotic (Syn) treatment attenuated learned fear-like behavior recognition memory impairment in immobilized-stressed rats. In this study, we further investigated the physical, behavior, cellular mechanisms underlying effects Syn and/or Vlx on brain intestinal functions stressed Adult male Wistar rats, aged 8 weeks old were subjected to 14 days...